Tissue / Organ Biology & Endocrinology

The research of faculty in the areas of Tissue/Organ Biology & Endocrinology addresses biology at the level of the organism, moving from the molecular biology of the individual cell to integrated tissues, organs and organisms, and asking how this biology impacts human disease. UCSF has a long history in the biological sciences that relate to this area of research that is reflected in current Organized Research Units including the Center for Reproductive Sciences, Diabetes Center, Hormone Research Institute, Metabolic Unit, Liver Center, Cardiovascular Research Institute, Lung Biology Center, and Gladstone Institutes.

Among the specific research topics pursued are the genetic basis of obesity, the role of extracellular matrix in regulating cell function, the biological basis of diabetes, reproductive biology, adrenal function, ion fluxes in skin and epithelium, and calcium homeostasis.

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Participating Faculty

Tamara Alliston, PhD

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Our research focuses on the molecular pathways controlling mesenchymal stem cell differentiation

Kaveh Ashrafi, PhD

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Neurobiology
Research Summary: 
at, Feeding, and Metabolic Regulation of Neural Functions

Kamran Atabai, MD

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Immunology
Research Summary: 
Extracellular matrix regulation of metabolism, pulmonary disease, and cardiovascular disease

James Bayrer, MD, PhD

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Our laboratory deciphers the molecular machinery controlling intestinal epithelial renewal and gut signaling via genetic disease models coupled with mouse and human intestinal organoids.

Aditi Bhargava, PhD

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Neurobiology
Research Summary: 
Gut-brain cross-talk: mediation by stress hormone system

Daniel Bikle, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Regulation of cellular differentiation and function by calciotropic hormones

Laura Bull, PhD

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Genetics approaches to study of the biology of the liver in health and disease

George Caughey, MD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Lung Peptidases in Allergy and Host Defense

Tammy T. Chang, MD, PhD

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Understanding the basic biology and realizing applicable strategies to enable liver tissue engineering for the treatment of end-stage liver disease.

Andy Chang, PhD

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Neurobiology
Research Summary: 
We are interested in mechanisms of oxygen and metabolite sensing in mammals.

Harold Chapman

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Stem Cells in Lung Tissue Remodeling and Repair

Myriam Chaumeil, PhD

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Our research goal is to develop innovative, mechanism-driven magnetic resonance (MR) metabolic imaging methods for improved detection of neurological disorders and monitoring of therapy response.

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