Dylan Chan, MD, PhD

Professor in Residence
Otolaryngology
+1 415 353-2870
Research Description: 

Dylan K. Chan, MD, PhD, is Professor in Residence and Director of the Children’s Communication Center (CCC) in the Department of Otolaryngology – Head and Neck Surgery (ONHS) at the University of California, San Francisco. He received his PhD in Sensory Neuroscience from the Rockefeller University in New York, and he obtained his medical degree from Weill Medical College of Cornell University, New York. Dr. Chan completed his ONHS residency from Stanford University School of Medicine, California, followed by a Pediatric Otolaryngology fellowship at the Seattle Children’s Hospital, Washington.

In 2014, Dr. Chan established the UCSF Children’s Communication Center, which is devoted to delivering multidisciplinary care for families of deaf and hard of hearing children, performing community outreach and education, and conducting clinical and translational research projects. By addressing existing shortfalls in care delivery and developing novel treatments, he hopes to significantly impact hearing health in children. His laboratory is interested in investigating the mechanisms of hearing and deafness, using live imaging in animal models of acquired and genetic hearing loss to directly visualize how calcium dysregulation and stress pathways affect the function and survival of sensory hair cells. These studies have led to identification of molecular targets for the treatment of hearing loss caused by noise and cisplatin exposure.

Dr. Chan is a scientific reviewer for various scientific journals, frequent invited speaker at local and national conferences, and has published over 15 articles

Specialty:
Cochlear Implant Surgery and Pediatric Otolaryngology

Expertise:
Pediatric hearing loss, cochlear implantation, chronic ear surgery, microtia/atresia, ear canal reconstruction.

Professional Interests:
Multidisciplinary management, diagnostic testing, genetics, and treatment of deaf and hard of hearing children; health disparities in treatment and outcomes of pediatric hearing loss;gnetics of hearing and deafness; pediatric communication disorders.

Education and Training:
• PhD: The Rockefeller University, New York, NY – Sensory Neuroscience
• Medical School: Weill Medical College of Cornell University, New York, NY
• Residency: Stanford University School of Medicine, CA – Otolaryngology-Head and Neck Surgery
• Fellowship: Seattle Children’s Hospital, WA – Pediatric Otolaryngology

Awards and Honors:
• 2014 ANS/AAO-HNSF - Herbert Silverstein Award
• 2014 American Hearing Research Foundation Research Grant
• 2015 American Society for Pediatric Otolaryngology Career Development Award

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
In our lab, we use live imaging in the cochlea to visualize how calcium dysregulation and stress pathways cause hearing loss, to help us identify molecular targets for treatment.
Featured Publications: 

Deletion of Tmtc4 activates the unfolded protein response causing postnatalhearing loss.

The Journal of clinical investigation

Li J, Akil O, Rouse SL, McLaughlin CW, Matthews IR, Lustig LR, Chan DK, Sherr EH

TMTC4 is a hair-cell-specific human deafness gene.

JCI insight

Li J, Choi BY, Eltawil Y, Ismail Mohamad N, Park Y, Matthews IR, Han JH, Kim BJ, Sherr EH, Chan DK

Noise induces Ca2+ signaling waves and Chop/S-Xbp1 expression in the hearing cochlea.

JCI insight

Park Y, Li J, Ismail Mohamad N, Matthews IR, Santra P, Sherr EH, Chan DK

Modulating the Unfolded Protein Response with ISRIB Mitigates Cisplatin Ototoxicity.

bioRxiv : the preprint server for biology

Li J, Rouse SL, Matthews IR, Sherr EH, Chan DK

Synaptic ribbon dynamics after noise exposure in the hearing cochlea.

Communications biology

Ismail Mohamad N, Santra P, Park Y, Matthews IR, Taketa E, Chan DK