BMS Journal Club

2019-20 Journal Club Schedule

Dates: September 5, 2019 - May 21, 2020

Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room MH-1405, Mission Bay.
Links to the live stream and recorded video are in the sidebar.


**If you're watching the video stream at Mission Bay and would like to ask the speaker a question, send a DM via Twitter to @UCSF_BMS_JC and someone at Parnassus will ask your question for you.


See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.


September 5, 2019

Mary Helen Barcellos-Hoff (faculty)
"Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts"
10.1158/2159-8290.CD-19-0094 Published August 2019

Gokul Ramadoss (student)
"Careful Cas9 Cutting Cures Condemned Cochleas"
György et al. Allele-specific gene editing prevents deafness in a model of
dominant progressive hearing loss. Nat Med. 2019 Jul;25(7):1123-1130. doi:
10.1038/s41591-019-0500-9. Epub 2019 Jul 3.

Coaches: Aaron Tward and Bruce Conklin


September 12, 2019

Jeoung-Sook Shin (faculty)
"Role of protein crystallization in asthma"
Persson et al., 'Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.' Science. 2019 May 24;364(6442). pii: eaaw4295. doi: 10.1126/science.aaw4295.

Raymond Dai (student)
"A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies"
Boettcher, S. et al. (2019). A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science 365 (6453), 599-604. doi: 10.1126/science.aax3649
Coaches: Joe Costello and Kevin Shannon


September 19, 2019

Isha Jain (faculty)
"The Treasure Hunt for New Oxygen Sensors"
Masson et al., ‘Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.’ Science. 2019 Jul 5;365(6448):65-69. doi: 10.1126/science.aaw0112.

Yewande Alabi (student)
"Phase separation and nuclear protein quality control: How the nucleolus promotes nuclear protein maintenance under stress"
Frottin, F. et al. (2019). The nucleolus functions as a phase-separated protein quality control compartment. Science. doi: 10.1126/science.aaw9157
Coaches: Bill DeGrado and Aimee Kao


September 26, 2019

Stephen Floor (faculty)
"This is your brain on lipoic acid: small molecule control of phase separation and neurodegeneration."
Wheeler, R. et al. 'Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease.' doi:10.1101/721001

Carlos Zuazo (student)
"Dreams From My Father: Neuronal Small RNAs Control Behavior Transgenerationally."
Posner et al. 'Neuronal Small RNAs Control Behavior Transgenerationally.' Cell 177, 1814–1826. June 13, 2019.
Coaches: Shaeri Mukherjee and Stephen Floor


October 3, 2019

Rohit Bose (faculty)
"Reversing oncogenic differentiation: can Humpty Dumpty be put together again?"
Walter et al., 'RB constrains lineage fidelity and multiple stages of tumour progression and metastasis' Nature volume 569, pages 423–427 (2019).

Kirsten Chen (student)
"An Emerging Panacea in Our Bodies - Microbiome"
Scheiman et al., 'Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism', Nature Medicine 25, 1104–1109 (2019)
Coaches: Katie Pollard and Peter Turnbaugh


October 10, 2019

Sophie Dumont (faculty)
"How mammalian oocytes build a spindle without centrosomes"
So et al., A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes. Science, Jun 28; 364. (2019).

Megan Montoya (student)
"Immune-suppressive tumor microenvironment leads to poor prognosis in Glioblastoma patients"
Alban et al., Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis. JCI Insight. 2018;3(21):e122264
Coaches: Hideho Okada and Noriyuki Kasahara


October 24, 2019

Andy Chang (faculty)
"What worms getting high can tell us about opioid signaling."
Wang et al., Genetic behavioral screen identifies an orphan anti-opioid system. Nature, Sep 20; 365(6459): 1267-1273 (2019).

Darwin Kwok (student)
"Connecting the Nodes Behind Gliomas: Electrical and synaptic integration of glioma into neural circuits."
Venkatesh et al. "Electrical and synaptic integration of glioma into neural circuits" Nature 573, 539-545 (September 18, 2019).
Coaches: David Raleigh and Erik Ullian


October 31, 2019

Elliott Sherr (faculty)
"A gene for you, a gene for me?"
J. Kim et al. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. October 24, 2019. N Engl J Med 2019; 381:1644-1652

Bahar Zirak (student)
"Tumor Heterogeneity and Immune Response in Melanoma"
Wolf et al. UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma. 2019, Cell 179, 219–235. 
Coaches: Melissa Reeves and Rohit Bose


November 7, 2019

Elphege Nora (faculty)
"The Energetics and Physiological Impact of Cohesin Extrusion."
Vian, Pękowska, Rao et al., The Energetics and Physiological Impact of Cohesin Extrusion. Cell 2018, May 17;173(5):1165-1178.e20.

 


November 14, 2019

Bjoern Schwer (faculty)
"To live longer, give your neurons some REST"
Zullo et al., Regulation of lifespan by neural excitation and REST. Nature, 574, pages 359–364 (2019).

Adam Wade-Vallance (student)
"There's just enough material here for a broadly-neutralizing vaccine."
Sangesland M et al. Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus. Immunity. 2019;51(4):735-49.
Coach: Chris Allen and Julie Zikherman


November 21, 2019

Valerie Weaver (faculty)
"Sometimes being fat is a good thing"
Dana Ishay-Ronen et al. Gain fat - Lose metastasis: Converting invasive breast cancer cells into adipocytes inhibits cancer metastasis. Cancer Cell 35, 17-32 2019

Nour Abdulhay (student)
"The Tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals."
Chavez et al., The Tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals. eLife 2019;8:e47682
Coaches: Noelle L'Etoile and Elphege Nora


January 9, 2020

David Solomon (faculty)
TBD

Saumya Bollam (student)
TBD


January 16, 2020

David Raliegh (faculty)
TBD

Rhogerry Deshycka (student)
TBD


January 30, 2020

Diana Laird (faculty)
TBD

Brian Woo (student)
TBD


February 13, 2020

Ed Hsiao (faculty)
TBD

Nick Mroz (student)
TBD


February 20, 2020

Abby Buchwalter (faculty)
TBD

Vikas Daggubati (student)
TBD


February 27, 2020

Yashodara Abeykoon (student)
TBD

Than Kyaw (student)
TBD


March 5, 2020

Oscar Yip (student)
TBD

Irek Habrylo (student)
TBD


March 12, 2020

Nebat Ali (student)
TBD

Matt Ryan (student)
TBD


March 19, 2020

Alyssa Indart (student)
TBD

Jackson Gardner (student)
TBD

 


March 26, 2020

Rachel DeBarge (student)
TBD

Ben Wheeler (student)
TBD


April 2, 2020

Jacqueline Yee (student)
TBD

Anthony Chang (student)
TBD


April 9, 2020

Cambria Chou-Freed (student)
TBD

Jessica Wang (student)
TBD


April 16, 2020

Brandon Desousa (student)
TBD

Nicole Tsai (student)
TBD


April 23, 2020

Mariko Foecke (student)
TBD

Sonia Scaria (student)
TBD


April 30, 2020

Sophie Guldberg (student)
TBD

Dianne Laboy Cintron (student)
TBD


May 7, 2020

Zach Howard (student)
TBD

Erin Huiting (student)
TBD


May 14, 2020

Niko Eng (student)
"L1 and B1 repeats blueprint the spatial organization of Chromatin"
Lu, J. Yuyang et al., L1 and B1 repeats blueprint the spatial organization of chromatin. bioRxiv, October 13, 2019. doi:10.1101/802173
Coach: Daniele Canzio