2018-19 Journal Club Schedule
Dates: September 6, 2018 - June 6, 2019
Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room MH-1405, Mission Bay.
Links to the live stream and recorded video are in the sidebar.
**If you're watching the video stream at Mission Bay and would like to ask the speaker a question, send a DM via Twitter to @UCSF_BMS_JC and someone at Parnassus will ask your question for you.
See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.
September 6, 2018
David Raleigh, PhD, MD (Faculty)
Title: "Patch(ing) together the structure and function of the Hedgehog pathway"
Gong, X. et al. Sturctural basis for the recognition of Sonic Hedgehog by human Patched 1. Science 10.1126/science.aas8935. (2018).
Lauren McHenry (Student)
Title: Don't drink the Kool-Aid: Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
Bunse, L., Pusch, S., Bunse, T., Sahm, F., Sanghvi, K., Friedrich, M., et al. (2018). Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nature Medicine, 1–25.
Coaches: William Weiss and Hidheo Okada
September 13, 2018
Elliott Sherr, MD, PhD (Faculty)
"Uncrossed wires of crowns and pyramids"
Marsh, A.P. et al. Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance. Nature Genetics 49(4), 511-514. (2017).
Donovan Trinidad (Student)
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
Sibener, Leah V., et al. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell 174(3), 672-687. (2018)
Coaches: Joel Ernst and Jason Cyster
September 20, 2018
James Rubenstein, MD, PhD (Faculty)
"Novel Role of S1P1 in Tumor Immune Escape"
Chongsathidkiet, P. et al. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nature Medicine 24, 1459-1468. (2018).
Rachel Nakagawa (Student)
"Run run as fast as you can, you can't catch me I'm a cancer cell: Disseminated cancer cells employ pericyte-like spreading for metastatic colonization"
Ekrem Emrah, E. et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nature Cell Biology 20, 966-978. (2018).
Coaches: Zena Werb and Diane Barber
September 27, 2018
Martin Kampmann, PhD (Faculty)
"A wrinkle in time: RNA velocity of single cells"
La Manno, G. et al. RNA velocity of single cells. Nature 560, 494-498. (2018).
Naznin Jahan (Student)
"Epigenetic regulation of brain region-specific microglia clearance activity"
Ayata, P. et al. Epigenetic regulation of brain region-specific microglia clearance activity. Nature Neuroscience 21, 1049-1060. (2018).
Coaches: Eric Huang and Mercedes Paredes
October 4, 2018
Raymond Swanson, MD (Faculty)
"Superoxide to the Rescue!"
Hervera, A. Reactive Oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Nat Cell Biol 20(3), 307-319. (2018).
Denise Allen (Student)
"When ROBOts Take Over Neurogenesis: Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels."
Cárdenas, A. et al. Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell 174, 590-606.e21. (2018).
Coaches: Tomasz Nowakowski and Alex Pollen
October 11, 2018
Andy Chang, PhD (Faculty)
"Plants fight back with a nervous system-like pathway"
Toyota, M. et al. Glutamate triggers long-distance, calcium-based plant defense signaling. Science 361(6407), 1112-1115. (2018).
Catherine Tan (Student)
"Cancer nuclei should relax: Too much tension promotes DNA damage"
Xi, Y. et. Al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. Journal of Cell Biology, epub. (2018).
Coaches: Todd Nystul and Jay Debnath
October 18, 2018
Stephen Floor, PhD (Faculty)
"One of these things is not like the other: Heritable variation in gene expression in clonal cell populations"
Shaffer, S.M. et al. Memory sequencing reveals heritable single cell gene expression programs assoicated with distinct cellular behaviors. bioRxiv, epub. (2018).
Casey Burnett (Student)
"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response"
Chen, G. et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature 560, 382-386. (2018).
Coaches: Matt Spitzer and Melissa Reeves
October 25, 2018
David Solomon, MD, PhD (Faculty)
"Cohesin is awesome and also functions as a critical regulator of chromatin architecture"
Rao, S.S.P. et al. Cohesin loss eliminates all loop domains. Cell 171(2), 305-320. (2017).
Lindsey Pieper (Student)
"Resistance is Futile: A Gut Bacterium-Derived Metabolite Mediates Colonization Resistance to Salmonella Infection"
Jacobson, A. et al. A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection. Cell Host Microbe 24, 296–307.e7. (2018).
Coaches: Joanne Engel and Peter Turnbaugh
November 1, 2018
Sophie Dumont, PhD (Faculty)
"Chromosome segregation fidelity: The tissue context matters"
Knouse, K.A., Lopez K.E., Bachofner, M. and A. Amon. Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture. Cell 175 (1), 200-211. (2018).
Kevin Wilkins (Student)
"It Takes Two to Translate: co-translational assembly of protein complexes in eukaryotes"
Shiber, A. et al. Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling. Nature 561, 268-272. (2018).
Coaches: Stephen Floor and Martin Kampmann
November 8, 2018
Xianhua Piao, MD, PhD (Faculty)
"Nature vs Nurture: How Ontogeny and Environment Shape Microglial Identity"
Bennett, F.C. et al. A combination of ontogeny and CNS environment establishes microglial identity. Nueron 98(6), 1170-1183.e8. (2018).
Yuhao Wang (Student)
"Notch an Advantage for Cancer: How Notch3 and β-catenin regulate persistence in lung cancer cells"
Arasada, R.R. et al. Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC. Nature Communications 9(3198): 1-16.(2018).
Coaches: Michael McManus and Eric Collisson
November 15, 2018
Maxence Nachury, PhD (Faculty)
"Microtubule dynamics: no longer just at the ends"
Vemu, A. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science 361(6404), eaau1504. (2018).
Camillia Azimi (Student)
"Are you in or are you out? Unique pattern of neutrophil migration and function during tumor progression"
Patel, S. et al. Unique pattern of neutrophil migration and function during tumor progression. Nature Immunology 19, 1236–1247. (2018).
Coaches: Kole Roybal and Melissa Reeves
November 29, 2018
Isha Jain, PhD (Faculty)
TBA
Isobel Hawes (Student)
TBA
December 6, 2018
Edward Hsiao, MD, PhD (Faculty)
TBA
Maxine Nelson (Student)
TBA
January 10, 2019
Diane Barber, PhD (Faculty)
TBA
David Shin (Student)
TBA
January 17, 2019
TBA (Faculty)
TBA
Ryan Ziffra (Student)
TBA
January 24, 2019
TBA (Faculty)
TBA
Nicholas Stevers (Student)
TBA
January 31, 2019
Nour Abdulhay (Student)
TBA
Emmy Li (Student)
TBA
February 7, 2019
TBA (Faculty)
TBA
Irene Chen (Student)
TBA
February 14, 2019
Tyler Fair (Student)
TBA
Fauna Yarza (Student)
TBA
February 21, 2019
Jennifer Umhoefer (Student)
TBA
Donovan Trinidad (Student)
TBA
February 28, 2019
Iowis Zhu (Student)
TBA
Cody Mowery (Student)
TBA
March 7, 2019
Marissa Chou (Student)
TBA
Darwin Kwok (Student)
TBA
March 14, 2019
Adam Wade-Vallance (Student)
TBA
Alyssa Indart (Student)
TBA
March 21, 2019
Kyle Kisor (Student)
TBA
Jiapei Chen (Student)
TBA
March 28, 2019
Tara McIntyre (Student)
TBA
Karen Chan (Student)
TBA
April 4, 2019
Abrar Choudhury (Student)
TBA
Marci Rosenberg (Student)
TBA
April 11, 2019
Rhogerry Deshycka (Student)
TBA
Kirsten Chen (Student)
TBA
April 18, 2019
Daphne Superville (Student)
TBA
Raymond Dai (Student)
TBA
April 25, 2019
Gokul Ramadoss (Student)
TBA
Saumya Bollam (Student)
TBA
May 2, 2019
Rachel DeBarge (Student)
TBA
Nick Mroz (Student)
TBA
May 9, 2019
Benjamin Wheeler (Student)
TBA
Julie Cole (Student)
TBA
May 16, 2019
Megan Montoya (Student)
TBA
Brian Woo (Student)
TBA
May 23, 2019
Carlos Zuazo (Student)
TBA
Yewande Alabi (Student)
TBA
May 30, 2019
Bahar Zirak (Student)
TBA
Niko Eng (Student)
TBA
June 6, 2019
Jackson Gardner (Student)
TBA
Priscila Munoz Sandoval (Student)
TBA