2022-23 Journal Club Schedule
Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location:In person at N-225 on the Parnassus campus, with a livestream/Zoom option as well. The Zoom link will be sent out with the email reminder sent to the BMS listservs. Please contact Demian Sainz if you are not already on one of our listservs.
Links to previous livestreams and recorded video are in the sidebar.
See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.
September 8, 2022
*Introduction to Journal Club with Journal Club co-Chairs Bruce Wang and Tien Peng*
Meagan Olive (student)
"The right to choose: Gamma delta T cells take up residence in the decidua for a novel role in early pregnancy"
Yang, S., et al. Early pregnancy human decidua gamma/delta T cells exhibit tissue resident and specific functional characteristics. Mol Hum Reprod. 2022 Jul 29;28(8):gaac023. doi: 10.1093/molehr/gaac023. PMID: 35758607.
Coaches: Tiffany Scharschmidt, MD & David Raleigh, MD, PhD
September 15, 2022
Arun Wiita, MD, PhD (faculty)
"On cloud IL-9: Engineering a next-level T-cell for adoptive immunotherapy"
Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, Song D, Rommel PC, Radaelli E, Young RM, Leonard WJ, Ribas A, June CH, Garcia KC. Potentiating adoptive cell therapy using synthetic IL-9 receptors. Nature. 2022 Jul;607(7918):360-365. doi: 10.1038/s41586-022-04801-2. Epub 2022 Jun 8. PMID: 35676488; PMCID: PMC9283313.
Jun Hyung Sin (student)
"KAT7 bites down, marking chromatin regions of AIRE-regulated loci in TECs"
Melanie Heinlein, Luke C. Gandolfo, Kelin Zhao, Charis E. Teh, Nghi Nguyen, Jonathan B. Baell, Yael Goldfarb, Jakub Abramson, Johannes Wichmann, Anne K. Voss, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Daniel H. D. Gray The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance Science Immunology (21 Jan 2022, Vol. 7, Issue No. 67)
Coaches: Jay Gardner, MD, PhD & Tony Defranco, PhD
September 22, 2022
Ashish Raj, PhD (faculty)
Montal, Victor et al. "Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes" Science Translational Medicine vol 14.655 (2022) doi:10.1126/scitranslmed.abn7273
Max Foisey (student)
"Finally! An engineered cell therapy paper that isn't about T cells..."
Nahmad, Alessio D et al. “In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice.” Nature biotechnology vol. 40,8 (2022): 1241-1249. doi:10.1038/s41587-022-01328-9
Coaches: Jason Cyster, PhD & Luke Gilbert, PhD
September 29, 2022
Cathryn Cadwell, MD, PhD (faculty)
"Brain cell type atlases: The key to understanding neurobiology, or aimless stamp collecting?"
Berg, J., Sorensen, S.A., Ting, J.T. et al. Human neocortical expansion involves glutamatergic neuron diversification. Nature 598, 151–158 (2021). https://doi.org/10.1038/s41586-021-03813-8
Charlotte Wang (student)
"All types of screens: unmasking cancer"
Kishton, R. J., et al. (2022). Cancer genes disfavoring T cell immunity identified via integrated systems approach. Cell reports, 40(5), 111153. https://doi.org/10.1016/j.celrep.2022.111153
Coaches: Julia Carnevale, MD & David Nguyen, MD, PhD
October 6, 2022
Matthew Stachler, MD, PhD (faculty)
"Determining the origins of esophageal adenocarcinoma. Big Data and complex manuscripts, trying to make sense of techniques you may not completely understand"
Nowicki-Osuch K, Zhuang L, Jammula S, Bleaney CW, Mahbubani KT, Devonshire G, Katz-Summercorn A, Eling N, Wilbrey-Clark A, Madissoon E, Gamble J, Di Pietro M, O'Donovan M, Meyer KB, Saeb-Parsy K, Sharrocks AD, Teichmann SA, Marioni JC, Fitzgerald RC. Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition. Science. 2021 Aug 13;373(6556):760-767. doi: 10.1126/science.abd1449. PMID: 34385390.
Kyla Foster (student)
"The Hitchhiker's Guide to the Brain: Glioblastoma Hijacks Neuronal Mechanisms for Brain Invasion"
Venkataramani V, Yang Y, Schubert MC, … Wick W, Kuner T, Winkler F. Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell. 2022 Aug 4;185(16):2899-2917.e31. doi: 10.1016/j.cell.2022.06.054. Epub 2022 Jul 31. PMID: 35914528.
Coaches: Betsy Crouch, MD, PhD & Harish Vasudevan, MD, PhD
October 13, 2022
Franklin Huang, MD, PhD (faculty)
"Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors"Nassar, A.H., Adib, E., Abou Alaiwi, S. et al. Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors, Cancer Cell,2022, ISSN 1535-6108,https://doi.org/10.1016/j.ccell.2022.08.022.\
Rita Loudermilk (student)
"Shining a Light on Cell-Cell Interactions"
Oslund, R.C., Reyes-Robles, T., White, C.H. et al. Detection of cell–cell interactions via photocatalytic cell tagging. Nat Chem Biol 18, 850–858 (2022). https://doi.org/10.1038/s41589-022-01044-0
Coaches: Alexis Combes, PhD & Gabi Fragiadakis, PhD
October 20, 2022
Xin Duan, PhD (faculty)
"May the force be with your neurons at the right moment"
Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures in a Mouse Model of Arthrogryposis
Shang Ma, et al, Ardem Patapoutian (Biorxiv, 2022) https://www.biorxiv.org/content/10.1101/2022.06.07.495164v1
Evan Semenza (student)
"This is your brain on (fatty) acid: metabolic involvement in the evolutionary expansion of the cerebral cortex"
Pinson, A., et al. (2022) Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. Science 377(6611). https://doi.org/10.1126/science.abl6422
Coaches: Corey Harwell, PhD & Daniel Lim, MD, PhD
October 27, 2022
Frank McCormick, PhD (faculty)
"Selfish Mutations and germline disease"
Maher GJ, Ralph HK, Ding Z, Koelling N, Mlcochova H, Giannoulatou E, Dhami P, Paul DS, Stricker SH, Beck S, McVean G, Wilkie AOM, Goriely A. Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes. Genome Res. 2018 Dec;28(12):1779-1790. doi: 10.1101/gr.239186.118. Epub 2018 Oct 24. PMID: 30355600; PMCID: PMC6280762.
Wendy Hung (student)
"Waste not, want not: glycolysis byproduct boosts anti-tumor immunity"
Feng, Q., Liu, Z., Yu, X. et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun 13, 4981 (2022). https://doi.org/10.1038/s41467-022-32521-8
Coaches: Rachel Rutishauser, MD, PhD & Sara Suliman, PhD, MPH
November 3, 2022
Timothy Henrich, MD (faculty)
TBD
Caroline Whitty (student)
"I'll have the de-CAF"
Krishnamurty, A.T., Shyer, J.A., Thai, M. et al. LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature (2022).
https://www.nature.com/articles/s41586-022-05272-1
Coaches: Dean Sheppard, MD & Eric Collisson, MD
November 10, 2022
Jialing Liu, PhD (faculty)
J. Terreros-Roncal, E. P. Moreno-Jiménez, M. Flor-García, C. B. Rodríguez-Moreno, M. F. Trinchero, B. Márquez-Valadez, F. Cafini, A. Rábano, M. Llorens-Martín.
Science 2021 374:1106-1113.
William Xie (student)
"T cells and Glia: Eng-aging in white matter"
Kaya, T., Mattugini, N., Liu, L. et al. CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci (2022). https://doi.org/10.1038/s41593-022-01183-6
Coaches: Andrew Yang, PhD & Ari Molofsky, MD, PhD
November 17, 2022
Adrian Erlebacher, MD, PhD (faculty)
"Brush your teeth to prevent arthritis"
Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities.
Li X, Wang H, Yu X, Saha G, Kalafati L, Ioannidis C, Mitroulis I, Netea MG, Chavakis T, Hajishengallis G. Cell. 2022 May 12;185(10):1709-1727.e18. doi: 10.1016/j.cell.2022.03.043. Epub 2022 Apr 27. PMID: 35483374
Stephanie Huard (student)
TBD
Colombo, G., Cubero, R.J.A., Kanari, L. et al. A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes. Nat Neurosci 25, 1379–1393 (2022). https://doi.org/10.1038/s41593-022-01167-6
Coaches: Dena Dubal, MD, PhD & Eric Huang, MD, PhD
December 1, 2022
Shibani Pati, MD, PhD (faculty)
"Treating Brain Cancer with Anti-histamines"
Chen J, Liu G, Wang X, Hong H, Li T, Li L, Wang H, Xie J, Li B, Li T, Lu D, Zhang Y, Zhao H, Yao C, Wen K, Li T, Chen J, Wu S, He K, Zhang WN, Zhao J, Wang N, Han Q, Xia Q, Qi J, Chen J, Zhou T, Man J, Zhang XM, Li AL, Pan X. Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling. Cell Stem Cell. 2022 Nov 3;29(11):1531-1546.e7. doi: 10.1016/j.stem.2022.09.009. Epub 2022 Oct 19. PMID: 36265493.
Kevin Ly (student)
"Have I seen you before? I think you need to be Trm'ed."
Fung HY, Teryek M, Lemenze AD, Bergsbaken T. CD103 fate mapping reveals that intestinal CD103- tissue-resident memory T cells are the primary responders to secondary infection. Sci Immunol. 2022 Nov 11;7(77):eabl9925. doi: 10.1126/sciimmunol.abl9925. Epub 2022 Nov 4. PMID: 36332012.
Coaches: Ari Molofsky, MD, PhD & Rachel Rutishauser, MD, PhD
December 8, 2022
Letitia Yang (student)
TBD
Robinson, M. J., Dowling, M. R., Pitt, C., O’Donnell, K., Webster, R. H., Hill, D. L., Ding, Z., Dvorscek, A. R., Brodie, E. J., Hodgkin, P. D., Quast, I., Tarlinton, D. M. (2022). Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response. Science Immunology, 7(76). https://doi.org/10.1126/sciimmunol.abm8389
Coaches: Julie Zikherman, MD & Jason Cyster, PhD
Holly Steininger (student)
"Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells"
Sara S Oltra, Laura Sin, Sara Colomo, María Pérez-López, Angela Molina-Crespo, Kyoung-Han Choi, Lidia Martinez, Saleta Morales, Cristina González-Paramos, Alba Orantes, Mario Soriano, Alberto Hernandez, Ana Lluch, Federico Rojo, Joan Albanell, Jae-Kyun Ko, David Sarrió, Gema Moreno-Bueno
Coaches: Erin Gordon, MD & Susan Lynch, PhD
January 26, 2023
Sophia Nelson (student)
"Fancy MAIT-ing you here: uncovering a new role for MAIT cells in meningeal homeostasis and cognitive function"
Zhang, Y., Bailey, J.T., Xu, E. et al. Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function. Nat Immunol 23, 1714–1725 (2022). https://doi.org/10.1038/s41590-022-01349-1
Coaches: Ari Molofsky, MD, PhD & Andrew Yang, PhD
February 2, 2023
Samuel Hoelscher (student)
"Life in Plastic, Not Fantastic"
Chan, J. M., Zaidi, S., Love, J. R., Zhao, J. L., Setty, M., Wadosky, K. M., Gopalan, A., Choo, Z.-N., Persad, S., Choi, J., LaClair, J., Lawrence, K. E., Chaudhary, O., Xu, T., Masilionis, I., Linkov, I., Wang, S., Lee, C., Barlas, A., … Sawyers, C. L. (2022). Lineage plasticity in prostate cancer depends on JAK/stat inflammatory signaling. Science, 377(6611), 1180–1191. https://doi.org/10.1126/science.abn0478
Coaches: Rohit Bose, MD, PhD & TBD
Nav Lally (student)
TBD
Diaz-Cuadros, M., Miettinen, T.P., Skinner, O.S. et al. Metabolic regulation of species-specific developmental rates. Nature 613, 550–557 (2023). https://doi.org/10.1038/s41586-022-05574-4
Coaches: Guo Huang, PhD & Vasanth Vedantham, MD, PhD
February 9, 2023
Letitia Yang (student)
TBD
Robinson, M. J., Dowling, M. R., Pitt, C., O’Donnell, K., Webster, R. H., Hill, D. L., Ding, Z., Dvorscek, A. R., Brodie, E. J., Hodgkin, P. D., Quast, I., Tarlinton, D. M. (2022). Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response. Science Immunology, 7(76). https://doi.org/10.1126/sciimmunol.abm8389
Coaches: Julie Zikherman, MD & Jason Cyster, PhD
Lexi Schneider (student)
TBD
Schiepers, A. et al. Molecular fate-mapping of serum antibody responses to repeat immunization. Nature 1–3 (2023) doi:10.1038/s41586-023-05715-3.
https://www.nature.com/articles/s41586-023-05715-3
Coaches: Andrew Yang, PhD & Jason Cyster, PhD
February 16, 2023
Serena Lu (student)
TBD
Miao, W., Porter, D.F., Lopez-Pajares, V., Siprashvili, Z., Meyers, R.M., Bai, Y., Nguyen, D.T., Ko, L.A., Zarnegar, B.J., Ferguson, I.D., et al. (2023). Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation. Cell 186, 80-97.e26. https://doi.org/10.1016/j.cell.2022.12.004
Coaches: Stephen Floor, PhD & Erica Hutchins, PhD
Zack Mullin-Bernstein (student)
"How Did We Get Here? Building Spindles in a World Without Directions"
Fukuyama, T. et al. Morphological growth dynamics, mechanical stability, and active microtubule mechanics underlying spindle self-organization. Proc. Natl. Acad. Sci. U. S. A. 119, e2209053119 (2022)
Coaches: Fred Chang, MD, PhD & Torsten Wittmann, PhD
February 23, 2023
Jingwen Ding (student)
TBD
Maddie Urbanek (student)
TBD
March 2, 2023
McKenzie Daanen (student)
TBD
Khang Nguyen (student)
TBD
March 9, 2023
Kai Trepka (student)
TBD
Minna Apostolova (student)
TBD
March 16, 2023
Jayden Ross (student)
TBD
Ivan Chavez (student)
TBD
March 23, 2023
Kadellyn Sandoval Gutierrez (student)
TBD
Amy Chen (student)
TBD
March 30, 2023
Julianne Riggs (student)
TBD
Soerens, A.G., Künzli, M., Quarnstrom, C.F. et al. Functional T cells are capable of supernumerary cell division and longevity. Nature (2023). https://doi.org/10.1038/s41586-022-05626-9
Coaches: TBD
Li Wang (student)
TBD
April 6, 2023
Amrik Kang (student)
TBD
Riana Hunter (student)
TBD
April 13, 2023
Gary Chan (student)
TBD
James Asaki (student)
TBD
April 20, 2023
Jing Chung (student)
TBD
Madison Lotstein (student)
TBD
April 27, 2023
Mingyang Ma (student)
TBD
Jaela Caston (student)
TBD
May 4, 2023
Isabel Shen (student)
TBD
Zachary Stensland (student)
TBD
May 11, 2023
Sara Misiukiewicz (student)
TBD
Manon Miller (student)
TBD
May 18, 2023
Rukman Thota (student)
TBD
Gabriella Kimmerly (student)
TBD
May 25, 2023
Sarah Castro (student)
TBD
Anita Qualls (student)
TBD
June 1, 2023
Jun Hyung Sin (student)
TBD
Victoria Bowcut (student)
TBD
June 8, 2023
Stephanie Huard (student)
TBD
Colombo, G., Cubero, R.J.A., Kanari, L. et al. A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes. Nat Neurosci 25, 1379–1393 (2022). https://doi.org/10.1038/s41593-022-01167-6
Coaches: Dena Dubal, MD, PhD & Eric Huang, MD, PhD
Holly Steininger (student)
"Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells"
Sara S Oltra, Laura Sin, Sara Colomo, María Pérez-López, Angela Molina-Crespo, Kyoung-Han Choi, Lidia Martinez, Saleta Morales, Cristina González-Paramos, Alba Orantes, Mario Soriano, Alberto Hernandez, Ana Lluch, Federico Rojo, Joan Albanell, Jae-Kyun Ko, David Sarrió, Gema Moreno-Bueno
Coaches: Erin Gordon, MD & Susan Lynch, PhD