BMS Journal Club

2018-19 Journal Club Schedule

Dates: September 6, 2018 - June 6, 2019

Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room MH-1405, Mission Bay.
Links to the live stream and recorded video are in the sidebar.

**If you're watching the video stream at Mission Bay and would like to ask the speaker a question, send a DM via Twitter to @UCSF_BMS_JC and someone at Parnassus will ask your question for you.

See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.

September 6, 2018

David Raleigh, PhD, MD (Faculty)
Title: "Patch(ing) together the structure and function of the Hedgehog pathway"
Gong, X. et al. Sturctural basis for the recognition of Sonic Hedgehog by human Patched 1. Science 10.1126/science.aas8935. (2018).

Lauren McHenry (Student)
Title: Don't drink the Kool-Aid: Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
Bunse, L., Pusch, S., Bunse, T., Sahm, F., Sanghvi, K., Friedrich, M., et al. (2018). Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nature Medicine, 1–25.
Coaches: William Weiss and Hidheo Okada

September 13, 2018

Elliott Sherr, MD, PhD (Faculty)
"Uncrossed wires of crowns and pyramids"
Marsh, A.P. et al. Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance. Nature Genetics 49(4), 511-514. (2017).

Donovan Trinidad (Student)
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
Sibener, Leah V., et al. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell 174(3), 672-687. (2018)
Coaches: Joel Ernst and Jason Cyster

September 20, 2018

James Rubenstein, MD, PhD (Faculty)
"Novel Role of S1P1 in Tumor Immune Escape"
Chongsathidkiet, P. et al. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nature Medicine 24, 1459-1468. (2018).

Rachel Nakagawa (Student)
"Run run as fast as you can, you can't catch me I'm a cancer cell: Disseminated cancer cells employ pericyte-like spreading for metastatic colonization"
Ekrem Emrah, E. et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nature Cell Biology 20, 966-978. (2018).
Coaches: Zena Werb and Diane Barber

September 27, 2018

Martin Kampmann, PhD (Faculty)
"A wrinkle in time: RNA velocity of single cells"
La Manno, G. et al. RNA velocity of single cells. Nature 560, 494-498. (2018).

Naznin Jahan (Student)
"Epigenetic regulation of brain region-specific microglia clearance activity"
Ayata, P. et al. Epigenetic regulation of brain region-specific microglia clearance activity. Nature Neuroscience 21, 1049-1060. (2018).
Coaches: Eric Huang and Mercedes Paredes

October 4, 2018

Raymond Swanson, MD (Faculty)
"Superoxide to the Rescue!"
Hervera, A. Reactive Oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Nat Cell Biol 20(3), 307-319. (2018).

Denise Allen (Student)
"When ROBOts Take Over Neurogenesis: Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels."
Cárdenas, A. et al. Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell 174, 590-606.e21. (2018).
Coaches: Tomasz Nowakowski and Alex Pollen

October 11, 2018

Andy Chang, PhD (Faculty)
"Plants fight back with a nervous system-like pathway"
Toyota, M. et al. Glutamate triggers long-distance, calcium-based plant defense signaling. Science 361(6407), 1112-1115. (2018).

Catherine Tan (Student)
"Cancer nuclei should relax: Too much tension promotes DNA damage"
Xi, Y. et. Al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. Journal of Cell Biology, epub. (2018).
Coaches: Todd Nystul and Jay Debnath

October 18, 2018

Stephen Floor, PhD (Faculty)
"One of these things is not like the other: Heritable variation in gene expression in clonal cell populations"
Shaffer, S.M. et al. Memory sequencing reveals heritable single cell gene expression programs assoicated with distinct cellular behaviors. bioRxiv, epub. (2018).

Casey Burnett (Student)
"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response"
Chen, G. et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature 560, 382-386. (2018).
Coaches: Matt Spitzer and Melissa Reeves

October 25, 2018

David Solomon, MD, PhD (Faculty)
"Cohesin is awesome and also functions as a critical regulator of chromatin architecture"
Rao, S.S.P. et al. Cohesin loss eliminates all loop domains. Cell 171(2), 305-320. (2017).

Lindsey Pieper (Student)
"Resistance is Futile: A Gut Bacterium-Derived Metabolite Mediates  Colonization Resistance to Salmonella Infection"
Jacobson, A. et al. A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection. Cell Host Microbe 24, 296–307.e7. (2018).
Coaches: Joanne Engel and Peter Turnbaugh

November 1, 2018

Sophie Dumont, PhD (Faculty)
"Chromosome segregation fidelity: The tissue context matters"
Knouse, K.A., Lopez K.E., Bachofner, M. and A. Amon. Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture. Cell 175 (1), 200-211. (2018).

Kevin Wilkins (Student)
"It Takes Two to Translate: co-translational assembly of protein complexes in eukaryotes"
Shiber, A. et al. Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling. Nature 561, 268-272. (2018).
Coaches: Stephen Floor and Martin Kampmann

November 8, 2018

Xianhua Piao, MD, PhD (Faculty)
"Nature vs Nurture: How Ontogeny and Environment Shape Microglial Identity"
Bennett, F.C. et al. A combination of ontogeny and CNS environment establishes microglial identity. Nueron 98(6), 1170-1183.e8. (2018).

Yuhao Wang (Student)
"Notch an Advantage for Cancer: How Notch3 and β-catenin regulate persistence in lung cancer cells"
Arasada, R.R. et al. Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC. Nature Communications 9(3198): 1-16.(2018).
Coaches: Michael McManus and Eric Collisson

November 15, 2018

Maxence Nachury, PhD (Faculty)
"Microtubule dynamics: no longer just at the ends"
Vemu, A. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science 361(6404), eaau1504. (2018).

Camillia Azimi (Student)
"Are you in or are you out? Unique pattern of neutrophil migration and function during tumor progression"
Patel, S. et al. Unique pattern of neutrophil migration and function during tumor progression. Nature Immunology 19, 1236–1247. (2018).
Coaches: Kole Roybal and Melissa Reeves

November 29, 2018

Isha Jain, PhD (Faculty)

Isobel Hawes (Student)

December 6, 2018

Edward Hsiao, MD, PhD (Faculty)

Maxine Nelson (Student)

January 10, 2019

Diane Barber, PhD (Faculty)

David Shin (Student)

January 17, 2019

TBA (Faculty)

Ryan Ziffra (Student)

January 24, 2019

TBA (Faculty)

Nicholas Stevers (Student)

January 31, 2019

Nour Abdulhay (Student)

Emmy Li (Student)

February 7, 2019

TBA (Faculty)

Irene Chen (Student)

February 14, 2019

Tyler Fair (Student)

Fauna Yarza (Student)

February 21, 2019

Jennifer Umhoefer (Student)

Donovan Trinidad (Student)

February 28, 2019

Iowis Zhu (Student)

Cody Mowery (Student)

March 7, 2019

Marissa Chou (Student)

Darwin Kwok (Student)

March 14, 2019

Adam Wade-Vallance (Student)

Alyssa Indart (Student)

March 21, 2019

Kyle Kisor (Student)

Jiapei Chen (Student)

March 28, 2019

Tara McIntyre (Student)

Karen Chan (Student)

April 4, 2019

Abrar Choudhury (Student)

Marci Rosenberg (Student)

April 11, 2019

Rhogerry Deshycka (Student)

Kirsten Chen (Student)

April 18, 2019

Daphne Superville (Student)

Raymond Dai (Student)

April 25, 2019

Gokul Ramadoss (Student)

Saumya Bollam (Student)

May 2, 2019

Rachel DeBarge (Student)

Nick Mroz (Student)

May 9, 2019

Benjamin Wheeler (Student)

Julie Cole (Student)

May 16, 2019

Megan Montoya (Student)

Brian Woo (Student)

May 23, 2019

Carlos Zuazo (Student)

Yewande Alabi (Student)

May 30, 2019

Bahar Zirak (Student)

Niko Eng (Student)

June 6, 2019

Jackson Gardner (Student)

Priscila Munoz Sandoval (Student)