BMS Journal Club

2022-23 Journal Club Schedule

Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location:In person at N-225 on the Parnassus campus, with a livestream/Zoom option as well. The Zoom link will be sent out with the email reminder sent to the BMS listservs. Please contact Demian Sainz if you are not already on one of our listservs.
Links to previous livestreams and recorded video are in the sidebar.

See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.

September 7, 2023

Peter Bruno (faculty)
"Vaccine-boosting improves CAR-T therapy and host immune response"
L. Ma, et al., Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity. Cell 186, 3148-3165.e20 (2023).

Isabelle Young (student)
"Scribble mis-localization induces adaptive resistance to KRASG12C inhibitors"
Adachi Y, Kimura R, Hirade K, et al. Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS. Nat Cancer. 2023;4(6):829-843. doi:10.1038/s43018-023-00575-2
Coaches: Jonathan Ostrem, MD, PhD & Michael Waterfield, MD, PhD

October 19, 2023

Michael Alexanian (faculty)
"New Frontiers in Epigenomics: Chromatin Remodeling in Alzheimer’s disease"
Xiong, James, Boix at al.,  Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion. 
Cell. 2023 Sep 28;186(20):4422-4437.e21. doi: 10.1016/j.cell.2023.08.040

Gary Chan (student)
"Gotta Target 'Em All: Reprogram myeloid cells in glioblastoma via KDM6B inhibition"
Goswami, S., Raychaudhuri, D., Singh, P. et al. Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade. Nat Cancer (2023).
Coaches: Joe Costello, PhD & Hideho Okada, MD, PhD

October 26, 2023

Rukman Thota (student)
"James Bonds favorite tumor model"
Chen, D. et al. CTLA-4 blockade induces CD4+ T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma. Immunity 56, 2086-2104.e8 (2023).
Coaches: Alexis Combes, PhD & Andrew Yang, PhD

November 9, 2023

Elphege Nora (faculty)
"Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus"
Gjaltema et al., Molecular Cell

Jing-Yi Chung (student)
"A new macrophage polarity called “CS” "
Bill, R. et al., CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science 381,515-524(2023). DOI:10.1126/science.ade2292
Coaches: Matt Spitzer, PhD & Roarke Kamber, PhD

November 16, 2023

Khang Nguyen (student)
"The Last of the TME (TumorMycoEnvironment)" 
Liu, Ning-Ning et al. “The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells.” Cancer cell, S1535-6108(23)00288-X. 19 Sep. 2023, doi:10.1016/j.ccell.2023.08.012
Coaches: Jeroen Roose, PhD & Mary Helen Barcellos-Hoff, PhD

December 7, 2023

Jayden Ross (student)
"CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice"
Sun, S., Meng, Y., Li, M. et al. CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice. Nat Aging 3, 1401–1414 (2023).
Coaches: Betsy Crouch, MD, PhD & Ethan Winkler, MD, PhD

December 14, 2023

David Raleigh (faculty)
"Two wrongs apparently make one wrong a little less wrong."
Ling, A.L., Solomon, I.H., Landivar, A.M. et al. Clinical trial links oncolytic immunoactivation to survival in glioblastoma. Nature 623, 157–166 (2023).

Max Pass (student)
“The one that didn’t get away: a distinct intratumoral population of cDC1s that amplify CD8 T cell responses"
Meiser, P. et al. A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity. Cancer Cell 0, (2023).
Coaches: Matt Spitzer, PhD & Max Krummel, PhD

January 11, 2024

Maddie Urbanek (student)
"Getting Groovy with Epi-Retro-seq"
Zhou, J., Zhang, Z., Wu, M. et al. Brain-wide correspondence of neuronal epigenomics and distant projections. Nature 624, 355–365 (2023).
Coaches: Betsy Crouch, MD, PhD & Cathryn Cadwell, MD, PhD

Sara Misiukiewicz (student)
"UndersTANding TANs: The local microenvironment drives activation of neutrophils in human brain tumors."
Maas RR, et al. The local microenvironment drives activation of neutrophils in human brain tumors. Cell. 2023 Oct 12;186(21):4546-4566.e27. doi: 10.1016/j.cell.2023.08.043. Epub 2023 Sep 27. PMID: 37769657.
Coaches: Roarke Kamber, PhD & Matt Spitzer, PhD

January 18, 2024

Julia McBride (student)
"An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis"
LaMarche, N.M., Hegde, S., Park, M.D., Maier, B.B., Troncoso, L., Le Berichel, J., Hamon, P., Belabed, M., Mattiuz, R., Hennequin, C., et al. (2023). An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature, 1–9. 10.1038/s41586-023-06797-9.
Coaches: Alejandro Sweet-Cordero, MD & TBD

Celeste Garza (student)
"Sensory neurons promote immune homeostasis in the lung"
Masato Tamari et al. Sensory neurons promote immune homeostasis in the lung. Cell. 2024, Pages 44-61.e17, SSN 0092-8674,
Coaches: Roberto Ricardo-Gonzalez, MD, PhD & Marlys Fassett, MD, PhD

January 25, 2024

Madeline McCanne (student)
"Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing"
Mishra, A. K. et al. Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing. Proceedings of the National Academy of Sciences 120, e2310221120 (2023).
Coaches: Jason Cyster, PhD & Max Krummel, PhD

Sangeetha Ramachandran (student)
"Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer"
Ayuso, J.M., Farooqui, M., Virumbrales-Muñoz, M. et al. Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer. Nat Commun 14, 6681 (2023).
Coaches: Oscar Aguilar, PhD & Catera Wilder, PhD

February 15, 2024

Sarah Castro (student)
“Save room for de(ssert) mushrooms: how fungi trigger an anti-tumor response”
Max M. Wattenberg et al. Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1.Sci. Immunol.8,eadj5097(2023).DOI:10.1126/sciimmunol.adj5097
Coaches: Oliva Lu, PhD & Karin Pelka, PhD

Ivan Chavez (student)
"Damsels in Drag: The evolutionary genomics of intersexual mimicry in damselflies"
Willink, B., Tunström, K., Nilén, S. et al. The genomics and evolution of inter-sexual mimicry and female-limited polymorphisms in damselflies. Nat Ecol Evol 8, 83–97 (2024).
Coaches: David Booth, PhD & TBD

February 22, 2024

Minna Apostolova (student)
"The (T cell) Mandela Effect: Flexibility in T cell Memory Formation"
Abadie, Kathleen et al. “Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision.” Immunity, S1074-7613(23)00537-X. 29 Jan. 2024, doi:10.1016/j.immuni.2023.12.006
Coaches: Matt Spitzer, PhD & Rachel Rutishauser, MD, PhD

Manon Miller (student)
"Interferon-ε is a tumor suppressor and restricts ovarian cancer"
Marks, Z.R.C., Campbell, N.K., Mangan, N.E. et al. Interferon-ε is a tumour suppressor and restricts ovarian cancer. Nature 620, 1063–1070 (2023).
Coaches: Katherine Fuh, MD, PhD & Alexis Combes, PhD

February 29, 2024

Clara Kochendoerfer (student)
"Two targets is better than one: a bispecific CAR T cell therapy for multiple myeloma"
Sun, F., et al. (2024). Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth. Nature communications, 15(1), 615.
Coaches: Justin Eyquem, PhD, MS, BS & Greg Allen, MD, PhD


March 7, 2024

Ankit Salhotra (student)
“CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus”
Badr, M. E., Zhang, Z., Tai, X., & Singer, A. (2023). CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus. Science, 382(6670), 534–541.
Coaches: Peter Bruno, PhD & Mark Anderson, MD, PhD

Claire Havig (student)
"Memories in the Making: Tracing the CD27-TRAF2-SHP-1 Pathway in Memory T cell Differentiation”
Jaeger-Ruckstuhl CA, Lo Y, Fulton E, Waltner OG, Shabaneh TB, Simon S, et al. Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks. Immunity. 2024;57(2):287-302.e12. doi: 10.1016/j.immuni.2024.01.011.
Coaches: Tiffany Scharschmidt, MD & Julia Carnevale, MD

March 14, 2024

Rachel Prorok (student)
“A Brainy Tale of Gene-ius Monitoring”
Lee, S., Nouraein, S., Kwon, J.J. et al. Engineered serum markers for non-invasive monitoring of gene expression in the brain. Nat Biotechnol (2024).
Coaches: Betsy Crouch, MD, PhD and David Solomon, MD, PhD

Nikhita Kirthivasan (student)
"GlycoRNAs on the Catwalk: Neutrophils Strutting their way to Inflammation"
Zhang N, et al. Cell surface RNAs control neutrophil recruitment. Cell. 2024 Feb 15;187(4):846-860.e17. doi: 10.1016/j.cell.2023.12.033. Epub 2024 Jan 22. PMID: 38262409
Coaches: Jason Cyster, PhD and Clifford Lowell, MD, PhD

March 21, 2024

Vickie Bowcut (student)
"Amino Alchemy: Crafting New G-Protein Activation States"
Hewitt N, Ma N, Arang N, et al. Catalytic site mutations confer multiple states of G protein activation. Sci Signal. 2023;16(772):eabq7842. doi:10.1126/scisignal.abq7842
Coaches: Frank McCormick, PhD, FRS & Jon Ostrem, MD, PhD

Serena Lu (student)
"Breaking the Code: Neuronal DNA Double-Strand Breaks and Neurodegeneration"
Dileep, V., et al (2023). Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell, 186(20), 4404–4421.e20.
Coaches: Dan Lim, MD, PhD & Abby Buchwalter, PhD

March 28, 2024

Riana Hunter (student)
“Decidual T cells protect against CMV at the maternal-fetal interface”
Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface
Or Alfi…, Dana G. Wolf, et al. Cell Reports (2024).

Coaches: Maggie Feeney, MD & Mary Prahl, MD

Mingyang Ma (student)
"Sleep's Tiny Guardians: Unveiling How Microglia Tune Our Slumber"
Ma, Chenyan, et al. "Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission." Nature Neuroscience (2024): 1-10.
Coaches: Ying-Hui Fu, PhD & Louis Ptacek, MD

April 4, 2024

Andrew Pan (student)
"Metalloproteases might make you moody: a link between the peripheral immune system and depression"
Cathomas, F., Lin, HY., Chan, K.L. et al. Circulating myeloid-derived MMP8 in stress susceptibility and depression. Nature 626, 1108–1115 (2024).
Coaches: Tom Nowakowski, PhD & Andrew Yang, PhD

Courtney Tamaki (student)
"Deterministic reprogramming of neutrophils within tumors"
Ng, M. S. F., et al. (2024). Deterministic reprogramming of neutrophils within tumors. Science (New York, N.Y.), 383(6679), eadf6493.
Coaches: Clifford Lowell, MD, PhD & Matthew Stachler, MD, PhD

April 11, 2024

Lily Zemelko (student)
“HIV vaccines induce CD8+ T cells with low antigen receptor sensitivity”
Stephen A. Migueles et al., HIV vaccines induce CD8+ T cells with low antigen receptor sensitivity. Science 382, 1270-1276(2023). DOI:10.1126/science.adg0514.
Coaches: Rachel Rutishauser, MD, PhD & Joel Ernst, MD

Tasha Tsao (student)
"KIRs & Heartache: NK cells and acute myocarditis post-COVID vaccination" 
Tsang HW, et al. The central role of natural killer cells in mediating acute myocarditis after mRNA COVID-19 vaccination. Med. 2024 Mar 15:S2666-6340(24)00080-1. doi: 10.1016/j.medj.2024.02.008. Epub ahead of print. PMID: 38521068.
Coaches: Oscar Aguilar, PhD & Timothy Henrich, MD

April 18, 2024

Jose Gomez (student)
"The Toll to Remember"
Jovasevic, Vladimir, et al. “Formation of Memory Assemblies through the DNA-Sensing TLR9 Pathway.” Nature News, Nature Publishing Group, 27 Mar. 2024, 
Coaches: Richard Locksley, MD& Tomasz Nowakowski, PhD

Kira Downey (student)
"Lessons in Immune Cell Match-Making: Building a Bispecific Dendritic Cell – T-Cell Engager to Remodel the Tumor Immune Landscape"
Itai et al. "Bispecific dendritic-T cell engager potentiates anti-tumor immunity" Cell 2024
Coaches: Greg Allen, MD, PhD & Kole Roybal, PhD

April 25, 2024

Charles Shen (student)
"Bone marrow plasma cells require P2RX4 to sense extracellular ATP"
Ishikawa, M., Hasanali, Z.S., Zhao, Y. et al. Bone marrow plasma cells require P2RX4 to sense extracellular ATP. Nature 626, 1102–1107 (2024).
Coaches: Jason Cyster, PhD & Oscar Aguilar, PhD

Trishna Patel (student)
"A Cancer-Fighting Dynamic Duo: Targeted Therapies and Macrophages Unite Against NSCLC"
Vaccaro K, et al. Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction. J Clin Invest. 2024 Mar 14:e169315. doi: 10.1172/JCI169315. Epub ahead of print. PMID: 38483480.
Coaches: Roarke Kamber, PhD & Paola Betancur, PhD

May 2, 2024

Karla DeLucas (student)
"Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy"
Renee R. Anderko et. al Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy. J Immunol 2024; ji2300672. 
Coaches: Oscar Aguilar, PhD & Rachel Rutishauser, MD, PhD

Rebecca Chu (student)
"Turning back the aging immunity clock."
Ross, J.B., Myers, L.M., Noh, J.J. et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature (2024).
Coaches: Serine Avagyan, MD, PhD & Cliff Lowell, MD, PhD

May 16, 2024

Lauren Tabor (student)
"Unlocking Neutrophil Potential: Antigen Presentation in the TME"
Wu, Yingcheng, et al. “Neutrophil profiling illuminates anti-tumor antigen-presenting potency.” Cell, vol. 187, no. 6, Mar. 2024,
Coaches: Peter Bruno, PhD & Matthew Krummel, PhD