BMS Journal Club

2024-25 Journal Club Schedule

Journal Club Co-Directors: Elizabeth Crouch, MD, PhD and Julia Carnevale, MD
Day/Time: Thursdays, 12:10-1:00 p.m. except as noted
Location:In person on the Parnassus campus, with a livestream/Zoom option to Mission Bay as well. The Zoom link will be sent out with the email reminder sent to the BMS listservs. Please contact Meredith Miner if you are not already on one of our listservs.
Links to previous livestreams and recorded video are in the sidebar.


See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.


September 12, 2024

Isha Jain (faculty)
"Sharing is Caring: The Therapeutic Potential of Mitochondrial Transfer"
Nakai, R., Varnum, S., Field, R.L. et al. Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01125-5 


Rebecca Chu (student)
“Keto Diet: Fad or Fab?”
Acuña-Catalán, D. et al. Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice, Cell Reports Medicine 5, (2024). 
Coaches: Saul Villeda, PhD 

Moderator: Tasha Tsao

September 19, 2024

Jose Angel Nicolas-Avila (faculty)
" A sneak peek to the bright side of immune cells: Microglia protect against age-associated brain pathologies"
Munro, David A.D. et al. Microglia protect against age-associated brain pathologies. Neuron, Volume 112, Issue 16, 2732 - 2748.e8 

Mackenzie Roberts (student)
“B(00)7-H4 - Giving T Cells a ‘License to Kill’ ”
Yu, Jiali, et al. “Progestogen-Driven B7-H4 Contributes to Onco-Fetal Immune Tolerance.” Cell, vol. 187, no. 17, Aug. 2024, pp. 4713-4732.e19. www.cell.com, https://doi.org/10.1016/j.cell.2024.06.012. 
Coaches: Adrian Erlebacher, MD, PhD & Betsy Crouch, MD, PhD

 

September 26, 2024

Peter Beernink (faculty)
"Do meningococcal outer membrane vesicle vaccines protect against gonorrhea?"
Molina JM, et al.; ANRS 174 DOXYVAC Study Group. Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design. Lancet Infect Dis. 2024 May 23:S1473-3099(24)00236-6. doi: 10.1016/S1473-3099(24)00236-6. PMID: 38797183.

Joy Okoro (student)
“CD4+ T Cells: The Surge Protectors of Mtb Immunity”
Bromley et al. (2024) Cell Immunity "CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection"   https://www.cell.com/immunity/fulltext/S1074-7613(24)00375-3 
Coaches: Sara Suliman, PhD, MPH & Joel Ernst, MD

Moderator: Lily Zemelko

October 3, 2024

Dena Dubal (faculty)
"Slow Down: IL11 and Extending Lifespan"
Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632, 157–165 (2024). https://doi.org/10.1038/s41586-024-07701-9

Jose Gomez (student)
"It was the best of times, it was the worst of times"
Kim, Tae Wan. “TNF-NF-ΚB-P53 Axis Restricts in Vivo Survival of HPSC- ...” Cell, 11 July 2024, www.cell.com/cell/fulltext/S0092-8674(24)00575-0. 
Coaches: Tomasz Nowakowski, PhD & Betsy Crouch, MD, PhD

Moderator: Jose Gomez

October 10, 2024

Arun Wiita (faculty)
"Taking evasive action: cloaking allogeneic CAR-T and CAR-NK cells from host rejection via adhesion ligand deletion"
Hammer Q, et al. Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies. Cell Stem Cell. 2024 Sep 5;31(9):1376-1386.e8. doi: 10.1016/j.stem.2024.06.011.

Claire Havig (student)
TBD
Lee, C.S., Chen, S., Berry, C.T. et al. Fate induction in CD8 CAR T cells through asymmetric cell division. Nature (2024). https://doi.org/10.1038/s41586-024-07862-7
Coaches: Greg Allen, MD, PhD & TBD

Moderator: Rachel Prorok

October 17, 2024

Peng He (faculty)
“Mapping the total transcriptome in space for FFPE tissues”
Bai, Zhiliang, et al. "Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues." Cell (2024).

Harnoor Virk (student)
TBD
Sáez-Cirión, Asier et al. “Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells.” Nature medicine, 10.1038/s41591-024-03277-z. 2 Sep. 2024, doi:10.1038/s41591-024-03277-z
Coaches: Nadia Roan, PhD & Oscar Aguilar, PhD

Moderator: Celeste Garza

October 24, 2024

Trevor Fidler (faculty)
TBD
Takaoka, M., Zhao, X., Lim, H.Y. et al. Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis. Nature (2024). https://doi.org/10.1038/s41586-024-07993-x

Charles Shen (student)
TBD
Gogoi, M., Clark, P.A., Ferreira, A.C.F. et al. ILC2-derived LIF licences progress from tissue to systemic immunity. Nature 632, 885–892 (2024). https://doi.org/10.1038/s41586-024-07746-w

Moderator: Zachary Holmes

October 31, 2024

David Raleigh (faculty)
"Semi-spiky tumor cells aren’t that scary"
Curry RN, Ma Q, McDonald MF, Ko Y, Srivastava S, Chin PS, He P, Lozzi B, Athukuri P, Jing J, Wang S, Harmanci AO, Arenkiel B, Jiang X, Deneen B, Rao G, Serin Harmanci A. "Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma." Cancer Cell. 2024 Oct 14;42(10):1713-1728.e6. doi: 10.1016/j.ccell.2024.08.009.

Julia McBride (student)
TBD
Kloosterman, Daan J., Johanna Erbani, Menno Boon, Martina Farber, Shanna M. Handgraaf, Masami Ando-Kuri, Elena Sánchez-López, et al. “Macrophage-Mediated Myelin Recycling Fuels Brain Cancer Malignancy.” Cell 187, no. 19 (September 19, 2024): 5336-5356.e30. https://doi.org/10.1016/j.cell.2024.07.030

Moderator: Harnoor Virk

November 7, 2024

Alejandro Sweet-Cordero (faculty)
"In vivo Crispr screens to identify genes involved in tumor-microenvironment interactions"
Su, P., Liu, Y., Chen, T. et al. In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions. Nat Genet 56, 1890–1902 (2024). https://doi.org/10.1038/s41588-024-01874-9

Zachary Holmes (student)
TBD
Tsuji, T., Tolstikov, V., Zhang, Y. et al. Light-responsive adipose-hypothalamus axis controls metabolic regulation. Nat Commun 15, 6768 (2024). https://doi.org/10.1038/s41467-024-50866-0
Coaches: Roarke Kamber, PhD, Saul Villeda, PhD

Moderator: Charles Shen

November 14, 2024

TBD (faculty)

Lily Zemelko (students)
TBD
Wang K., et al. Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells. Cancer Cell. 2024 Sep 9;42(9):1582-1597.e10. doi: 10.1016/j.ccell.2024.08.007. 
Coaches: Rachel Rutishauser, MD, PhD & Matt Spitzer, PhD

Moderator: Julia McBride

November 21, 2024

Nathan griffin (postdoc)

"Glands-plaining our way through lineage fidelity"

Centonze, A., Lin, S., Tika, E. et al. Heterotypic cell–cell communication regulates glandular stem cell multipotency. Nature 584, 608–613 (2020). https://doi.org/10.1038/s41586-020-2632-y

Celeste Garza (student)

Woodworth, Joshua S., et al. "MINCLE and TLR9 agonists synergize to induce Th1/Th17 vaccine memory and mucosal recall in mice and non-human primates." Nature Communications 15.1 (2024): 8959.

Coaches: Sara Suliman, PhD, MPH and Joel Ernst, MD

Moderator: Claire Havig

December 12, 2024

Trishna Patel (student)

Mollaoglu, Gurkan et al. “Ovarian cancer-derived IL-4 promotes immunotherapy resistance.” Cell, S0092-8674(24)01154-1. 25 Oct. 2024, doi:10.1016/j.cell.2024.10.006

Coaches: Roarke Kamber, PhD and Karin Pelka, PhD

Nikhita Kirthivasan (student)

"Diving behind the scenes of the first itch"

Flayer, C.H., Kernin, I.J., Matatia, P.R. et al. A γδ T cell–IL-3 axis controls allergic responses through sensory neurons. Nature 634, 440–446 (2024). https://doi.org/10.1038/s41586-024-07869-0

Coaches: Jason Cyster, PhD and Roberto Ricardo-Gonzalez, MD, PhD

Moderator: Julia McBride

Location: HSW-302, Parnassus & MH-1405, Mission Bay

January 9, 2025

Madeline McCanne (student)

"Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification"

Haag, S.M., Xie, S., Eidenschenk, C. et al. Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification. Nat Genet 56, 2493–2505 (2024)

Coaches: Michael McManus, PhD and John Liu, MD, PhD

Sangeetha Ramachandran (student)

Galvão IC, Lemoine M, Messias LA, Araújo PAORA, Geraldis JC, Yasuda CL, Alvim MKM, Ghizoni E, Tedeschi H, Cendes F, Rogerio F, Lopes-Cendes I, Veiga DFT. Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia. iScience. 2024 Nov 6;27(12):111337. doi: 10.1016/j.isci.2024.111337. PMID: 39640563; PMCID: PMC11617397.Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia

Coaches: Cathryn Cadwell, MD, PhD and Betsy Crouch, MD, PhD

Moderator: Lauren Tabor & Nikhita Kirthivasan 

Location: HSW-302, Parnassus & MH-1405, Mission Bay

January 16, 2025

Simon Wong (student)

Bailey, J.I., Puritz, C.H., Senkow, K.J. et al. Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19. Nat Immunol 25, 2097–2109 (2024). https://doi.org/10.1038/s41590-024-01975-x

Coaches: Roarke Kamber, PhD and Ari Molofsky, MD, PhD

Michelle Seeler (student)

"How Fallopian Tube Rheology Drives Cilia Formation and Function"

Abdul Halim, M.S., Dyson, J.M., Gong, M.M. et al. Fallopian tube rheology regulates epithelial cell differentiation and function to enhance cilia formation and coordination. Nat Commun 15, 7411 (2024).

Coaches: Helen Willsey, PhD and John Vaughen, PhD

Moderator: Clara Kochendoerfer & Madeline McCanne

Location: HSW-302, Parnassus & MH-1405, Mission Bay

January 23, 2025

Paul Leclerc (student)

"Mapping the Chaos: Spatial Transcriptomics Unveils the Hidden Landscapes of Triple-Negative Breast Cancer"

Wang, X., Venet, D., Lifrange, F. et al. Spatial transcriptomics reveals substantial heterogeneity in triple-negative breast cancer with potential clinical implications. Nat Commun 15, 10232 (2024)

Coaches: Alexis Combes, PhD and Karin Pelka, PhD

Caitlyn Dang (student)

"From Powerhouse to Problem"

Cai, S. et al. Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction. J Clin Invest 133, (2023)

Coaches: Isha Jain, PhD and Jose Angel Nicolas Avila, PhD

Moderator: Eva Gillis-Buck & Trishna Patel

Location: HSW-302, Parnassus & MH-1405, Mission Bay

January 30, 2025

Emily Chen (student)

"Subcutaneous Scaffolds: Giving CAR-T cells a Second Wind"

 Zhang, D.K.Y., Brockman, J.M., Adu-Berchie, K. et al. Subcutaneous biodegradable scaffolds for restimulating the antitumour activity of pre-administered CAR-T cells. Nat. Biomed. Eng (2024). https://doi.org/10.1038/s41551-024-01216-4

Coaches: Greg Allen, MD, PhD and Arun Wiita, MD, PhD

Helen Huynh (student)

"FNDC4 to the Rescue: Enhancing Cardiomyocyte Survival and Angiogenesis in Ischemia/Reperfusion Injury"

Zhang, X., Gao, YP., Dong, WS. et al. FNDC4 alleviates cardiac ischemia/reperfusion injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis in male mice. Nat Commun 15, 9667 (2024). https://doi.org/10.1038/s41467-024-53564-z

Coaches: Isha Jain, PhD and Michael Alexanian, PhD

Moderators: Karla DeLucas and Cassandra Martinez

Location: HSW-302, Parnassus & MH-1405, Mission Bay

February 6, 2025

Andrew Pan (student)

TBD

Eva Gillis-Buck (student)

TBD

Moderator: Courtney Tamaki & Liz Arouge

Location: HSW-302, Parnassus & MH-1405, Mission Bay

February 13, 2025

Cassandra Martinez (studnet)

TBD

Rachel Prorok (student)

TBD

Moderator: Joy Okoro & Shania Garrison

Location: HSW-302, Parnassus & MH-1405, Mission Bay

February 20, 2025

Tasha Tsao (student)

TBD

Karla DeLucas (student)

TBD

Moderator: Sangeetha Ramachandran & Monet Yuan

Location: HSW-302, Parnassus & MH-1405, Mission Bay

February 27, 2025

Christina Ekstrand (student)

TBD

Alvin Ha (student)

TBD

Moderator: Rebecca Chu & Becca Fulthorpe

Location: HSW-302, Parnassus & MH-1405, Mission Bay

March 6, 2025

Joseph Moreno (student)

TBD

Anthony Khalifeh (studeny)

TBD

Moderator: Paul Leclerc & Daniel Brody

Location: HSW-302, Parnassus & MH-1405, Mission Bay

March 13, 2025

Ananya Krishnapura (student)

TBD

Patrick Kennedy (student)

TBD

Moderator: Emily Chen & Simon Wong

Location: HSW-302, Parnassus & MH-1405, Mission Bay

March 20, 2025

Courtney Tamaki (student)

TBD

Clara Kochendoerfer (student)

TBD

Moderator: Christina Ekstrand & Alvin Ha

Location: HSW-302, Parnassus & MH-1405, Mission Bay

March 27, 2025

Lauren Tabor (student)

TBD

Joy Okoro (student)

TBD

Moderator: Joseph Moreno & Anthony Khalifeh

Location: HSW-302, Parnassus & MH-1405, Mission Bay

April 3, 2025

Shirley Bi (student)

TBD

Arren Ramsey (student)

TBD

Moderator: Ananya Krishnapura & Patrick Kennedy

Location: HSW-302, Parnassus & MH-1405, Mission Bay

April 10, 2025

Mandy Buck (student)

TBD

Gwen Cusing (student)

TBD

Moderator: Michelle Seeler & Helen Huynh

Location: HSW-302, Parnassus & MH-1405, Mission Bay

April 17, 2025

Andy Davis (student)

TBD

Jose Cedano (student)

TBD

Moderator: Caitlyn Dang & Angel Ruvalcaba

Location: HSW-302, Parnassus & MH-1405, Mission Bay

April 24, 2025

Viva Vykunta (student)

TBD

Dario Tagliaferri (student)

TBD

Moderator: Shriley Bi & Arren Ramsey

Location: HSW-302, Parnassus & MH-1405, Mission Bay

May 1, 2025

Dymtro Dorovskyi (student)

TBD

Jeremy Libang (student)

TBD

Moderator: Mandy Buck & Gwen Cusing

Location: HSW-302, Parnassus & MH-1405, Mission Bay

May 8, 2025

Liana Beld (student)

TBD

Julia Johannsen (student)

TBD

Moderator: Andy Davis & Jose Cedano

Location: HSW-302, Parnassus & MH-1405, Mission Bay

May 15, 2025

Shania Garrison (student)

TBD

Liz Arouge (student)

TBD

Moderator: Jeremy Libang & Dario Tagliaferri

Location: HSW-302, Parnassus & MH-1405, Mission Bay

May 22, 2025

Monet Yuan (student)

TBD

Angel Ruvalcaba (student)

TBD

Moderator: Dmytro Dorovskyi & Viva Vykunta

Location: HSW-302, Parnassus & MH-1405, Mission Bay

May 29, 2025

Becca Fulthorpe (student)

TBD

Daniel Brody (student)

TBD

Moderator: Liana Beld & Julia Johannsen

Location: HSW-302, Parnassus & MH-1405, Mission Bay