BMS Journal Club

2020-21 Journal Club Schedule

Dates:September 10th, 2020 - May 20th, 2021

Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Links to the live stream and recorded video are in the sidebar.


BMS Journal Club will be conducted via Zoom meeting until further notice. To watch live, join the meeting via the Zoom link sent out every week. You will also be able to ask questions of the presenters via Zoom. Please review our Zoom etiquette guidelines before joining the meeting.

The Zoom link and meeting password will be sent out to those on the BMS listservs the day of every journal club. Please contact Demian Sainz if you are not already on one of our listservs.

See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.

September 10, 2020

Mustafa Aydogan (Faculty)
"Organelle dynamics in non-dividing cells and their fate choice"
Iwata, R. et al. Mitochondrial dynamics in postmitotic cells regulate neurogenesis. Science 369(6505), 858-862. (2018).

Mariko Foecke (Student)
"Rewinding the Biological Clock: NMN Supplementation Reverses the Declining Quality of Maternally Aged Oocytes"
Miao Y, Cui Z, Gao Q, Rui R, Xiong B. Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes. Cell Rep. 2020;32(5):107987. doi:10.1016/j.celrep.2020.107987
Coaches: Diana Laird and Saul Villeda

September 17, 2020

Rong Wang (Faculty)
"It’s Smart to Make Friends with Blood Vessels"
Chow, B.W., Nuñez, V., Kaplan, L. et al. Caveolae in CNS arterioles mediate neurovascular coupling. Nature 579, 106–110 (2020).

Cambria Chou-Freed (Student)
"Rewinding the Biological Clock (Again): Can NAD+ Reverse Declining Circadian Rhythms with Age?"
Levine DC, Hong H, Weidemann BJ, et al. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. Mol Cell. 2020;78(5):835-849.e7. doi:10.1016/j.molcel.2020.04.010
Coaches: Louis Ptacek and Bassem Al-Sady

October 15, 2020

Mark Moasser (Faculty)
"Towards a deeper understanding of HER2-HER3 signaling"
Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers. Choi et al. Elife 2020; 9: e53934.

Zach Howard (Student)
"The 2020 Census: Intratumor Bacteria Edition"
Nejman, D., et al. 2020. The human tumor microbiome is composed of tumor type–specific intracellular bacteria. Science368(6494), 973-980.
Coaches: Peter Turnbaugh and Rohit Bose

October 22, 2020

Alejandro Sweet-Cordero (Faculty)
"Using single cell genomics to define state transitions in lung cancer."
LaFave et al., Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma, Cancer Cell (2020),

Erin Huiting (Student)
“Float like a butterfly, sting like a bacteria: STING-mediated signaling pathway has ancestral origin in bacteria”
Morehouse BR et al. STING cyclic dinucleotide sensing originated in bacteria. Nature. (2020).
Coaches: Joe Bondy-Denomy and Oren Rosenberg

November 12, 2020

Rohit Bose (Faculty)
"How the Making of Milk Or Saliva Might Become Lethal Adenocarcinoma"
Centonze A et al. Heterotypic cell-cell communication regulates glandular stem cell multipotency. Nature. 2020 Aug;584(7822):608-613. 

Anthony Chang (Student)
"When you creep on fat, it creeps back."
Ha et al., Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans, Cell (2020),
Coaches: Ari Molofsky and Peter Turnbaugh

January 7, 2021

Ziad Jowhar (Student)
Sequential Inverse Dysregulation of the RNA Helicases DDX3X and DDX3Y Facilitates MYC-Driven Lymphomagenesis"
Gong, Chun, et. al. Sequential Inverse Dysregulation of the RNA Helicases DDX3X and DDX3Y Facilitates MYC-Driven Lymphomagenesis. Available at SSRN: or
Coaches: Andrei Goga and Bill Weiss 

Christopher Chang (Student)
"Examining mitochondrial fitness in tumor infiltrating lymphocytes"
Yu, YR., Imrichova, H., Wang, H. et al. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. Nat Immunol 21, 1540–1551 (2020).
Coaches: Justin Eyquem and Kole Roybal

March 11, 2021

Zach Gardell (Student)
"Taking a page out of the embryonic playbook: Cancers repurpose diapause to persist through treatment"
Dhimolea, E., et al. An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence. Cancer Cell 2021, 0 (0).
Coaches: Andrei Goga and Ryan Corces 

Grace Hernandez (Student)
"Stanniocalcin stands in the way of effective APC-mediated phagocytosis by its interaction with mitochondrial Calreticulin in tumors"
Lin, H., Kryczek, I., Li, S., Green, M. D., Ali, A., Hamasha, R., Wei, S., Vatan, L., Szeliga, W., Grove, S., Li, X., Li, J., Wang, W., Yan, Y., Choi, J. E., Li, G., Bian, Y., Xu, Y., Zhou, J.,  Zou, W. (2021). Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance. Cancer Cell, 1–14.
Coaches: Jayanta Debnath and Matthew Krummel 

March 25, 2021

Karen Tolentino (Student)
“There’s a Fungus Among Us: The Role of Type 1 Immunity in C. Albicans Infection.”
Break TJ, Oikonomou V, Dutzan N, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371(6526):eaay5731. doi:10.1126/science.aay5731
Coaches: Joel Ernst and Babak Javid

Joe Germino (Student)
"Redefining cancer: Utilizing extracellular biomarkers to identify tumors"
Hoshino A, Kim HS, Bojmar L, et al. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020;182(4):1044-1061.e18. doi:10.1016/j.cell.2020.07.009
Coaches: Robert Blelloch and Robert Raffai

April 8, 2021

Mitchel Cole (Student)
"Epitranscriptomic Regulation of Oncogenes in Glioblastoma Models"
Dixit, D., Prager, B. C., Gimple, R. C., Poh, H. X., Wang, Y., Wu, Q., … Rich, J. N. (2021). The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells. Cancer Discovery, 11(2), 480–499.
Coaches: Aaron Diaz and Hani Goodarzi

Maya Lopez-Ichikawa (Student)
"Transcriptional and epigenetic programs define CD8+ T cell differentiation"
Yao, Chen, et al. "BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells." Nature immunology (2021): 1-11
Coaches: Justin Eyquem and Matt Spitzer

May 6, 2021

Hannah Driks (Student)
"Two sides to every story: A new role for MDM2 in anti-tumor immunity"
Zhou, J., Kryczek, I., Li, S. et al. The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity. Nat Immunol (2021).
Coaches: Hideho Okada and Justin Eyquem

Owen Jiang (Student)
“Hold T cell responsible: CD8 cells worsen anti-PD1 treatment outcome in NASH-driven HCC.”
Pfister, D., Núñez, N.G., Pinyol, R. et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature (2021).
Coaches: Emily Goldberg and Sagar Bapat

May 13, 2021

Marilyn Steyert (Student)
"You have your mother's barcode: Imaging cell lineage with a synthetic digital recording system"
Chow, K. H. K., Budde, M. W., Granados, A. A., Cabrera, M., Yoon, S., Cho, S., ... & Elowitz, M. B. (2021). Imaging cell lineage with a synthetic digital recording system. Science, 372(6538).
Coaches: Tomasz Nowakowski and Alex Pollen

Juliana Sucharov Costa (Student)
"Teaching an old brain new immune tricks: targeting aged myeloid cell metabolism rescues cognition"
Minhas, P.S., Latif-Hernandez, A., McReynolds, M.R. et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature 590, 122–128 (2021).
Coaches: Anna Molofsky and Max Krummel

May 20, 2021

Min Joo Kim (Student)
"Double Trouble: Whole Genome Duplications in Cancer Vulnerabilities"
Quinton, Ryan J., et al. "Whole-genome doubling confers unique genetic vulnerabilities on tumour cells." Nature 590.7846 (2021): 492-497.
Coaches: Isha Jain and Joe Costello