BMS Journal Club

2018-19 Journal Club Schedule

Dates: September 6, 2018 - June 6, 2019

Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room MH-1405, Mission Bay.
Links to the live stream and recorded video are in the sidebar.


**If you're watching the video stream at Mission Bay and would like to ask the speaker a question, send a DM via Twitter to @UCSF_BMS_JC and someone at Parnassus will ask your question for you.


See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.


September 6, 2018

David Raleigh, PhD, MD (Faculty)
Title: "Patch(ing) together the structure and function of the Hedgehog pathway"
Gong, X. et al. Sturctural basis for the recognition of Sonic Hedgehog by human Patched 1. Science 10.1126/science.aas8935. (2018).

Lauren McHenry (Student)
Title: Don't drink the Kool-Aid: Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
Bunse, L., Pusch, S., Bunse, T., Sahm, F., Sanghvi, K., Friedrich, M., et al. (2018). Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nature Medicine, 1–25.
Coaches: William Weiss and Hidheo Okada


September 13, 2018

Elliott Sherr, MD, PhD (Faculty)
"Uncrossed wires of crowns and pyramids"
Marsh, A.P. et al. Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance. Nature Genetics 49(4), 511-514. (2017).

Donovan Trinidad (Student)
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
Sibener, Leah V., et al. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell 174(3), 672-687. (2018)
Coaches: Joel Ernst and Jason Cyster


September 20, 2018

James Rubenstein, MD, PhD (Faculty)
"Novel Role of S1P1 in Tumor Immune Escape"
Chongsathidkiet, P. et al. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nature Medicine 24, 1459-1468. (2018).

Rachel Nakagawa (Student)
"Run run as fast as you can, you can't catch me I'm a cancer cell: Disseminated cancer cells employ pericyte-like spreading for metastatic colonization"
Ekrem Emrah, E. et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nature Cell Biology 20, 966-978. (2018).
Coaches: Zena Werb and Diane Barber


September 27, 2018

Martin Kampmann, PhD (Faculty)
"A wrinkle in time: RNA velocity of single cells"
La Manno, G. et al. RNA velocity of single cells. Nature 560, 494-498. (2018).

Naznin Jahan (Student)
"Epigenetic regulation of brain region-specific microglia clearance activity"
Ayata, P. et al. Epigenetic regulation of brain region-specific microglia clearance activity. Nature Neuroscience 21, 1049-1060. (2018).
Coaches: Eric Huang and Mercedes Paredes


October 4, 2018

Raymond Swanson, MD (Faculty)
"Superoxide to the Rescue!"
Hervera, A. Reactive Oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Nat Cell Biol 20(3), 307-319. (2018).

Denise Allen (Student)
"When ROBOts Take Over Neurogenesis: Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels."
Cárdenas, A. et al. Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell 174, 590-606.e21. (2018).
Coaches: Tomasz Nowakowski and Alex Pollen


October 11, 2018

Andy Chang, PhD (Faculty)
"Plants fight back with a nervous system-like pathway"
Toyota, M. et al. Glutamate triggers long-distance, calcium-based plant defense signaling. Science 361(6407), 1112-1115. (2018).

Catherine Tan (Student)
"Cancer nuclei should relax: Too much tension promotes DNA damage"
Xi, Y. et. Al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. Journal of Cell Biology, epub. (2018).
Coaches: Todd Nystul and Jay Debnath


October 18, 2018

Stephen Floor, PhD (Faculty)
"One of these things is not like the other: Heritable variation in gene expression in clonal cell populations"
Shaffer, S.M. et al. Memory sequencing reveals heritable single cell gene expression programs assoicated with distinct cellular behaviors. bioRxiv, epub. (2018).

Casey Burnett (Student)
"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response"
Chen, G. et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature 560, 382-386. (2018).
Coaches: Matt Spitzer and Melissa Reeves


October 25, 2018

David Solomon, MD, PhD (Faculty)
"Cohesin is awesome and also functions as a critical regulator of chromatin architecture"
Rao, S.S.P. et al. Cohesin loss eliminates all loop domains. Cell 171(2), 305-320. (2017).

Lindsey Pieper (Student)
"Resistance is Futile: A Gut Bacterium-Derived Metabolite Mediates  Colonization Resistance to Salmonella Infection"
Jacobson, A. et al. A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection. Cell Host Microbe 24, 296–307.e7. (2018).
Coaches: Joanne Engel and Peter Turnbaugh


November 1, 2018

Sophie Dumont, PhD (Faculty)
TBA

Kevin Wilkins (Student)
"It Takes Two to Translate: co-translational assembly of protein complexes in eukaryotes"
Shiber, A. et al. Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling. Nature 561, 268-272. (2018).
Coaches: Stephen Floor and Martin Kampmann


November 8, 2018

Xianhua Piao, MD, PhD (Faculty)
TBA

Yuhao wang (Student)
TBA


November 15, 2018

Maxence Nachury, PhD (Faculty)
TBA

Camillia Azimi (Student)
TBA


November 29, 2018

Isha Jain, PhD (Faculty)
TBA

Isobel Hawes (Student)
TBA


December 6, 2018

Edward Hsiao, MD, PhD (Faculty)
TBA

Maxine Nelson (Student)
TBA


January 10, 2019

Diane Barber, PhD (Faculty)
TBA

David Shin (Student)
TBA


January 17, 2019

TBA (Faculty)
TBA

Ryan Ziffra (Student)
TBA


January 24, 2019

TBA (Faculty)
TBA

Nicholas Stevers (Student)
TBA


January 31, 2019

Nour Abdulhay (Student)
TBA

Emmy Li (Student)
TBA


February 7, 2019

TBA (Faculty)
TBA

Irene Chen (Student)
TBA


February 14, 2019

Tyler Fair (Student)
TBA

Fauna Yarza (Student)
TBA


February 21, 2019

Jennifer Umhoefer (Student)
TBA

Donovan Trinidad (Student)
TBA


February 28, 2019

Iowis Zhu (Student)
TBA

Cody Mowery (Student)
TBA


March 7, 2019

Marissa Chou (Student)
TBA

Darwin Kwok (Student)
TBA


March 14, 2019

Adam Wade-Vallance (Student)
TBA

Alyssa Indart (Student)
TBA


March 21, 2019

Kyle Kisor (Student)
TBA

Jiapei Chen (Student)
TBA


March 28, 2019

Tara McIntyre (Student)
TBA

Karen Chan (Student)
TBA


April 4, 2019

Abrar Choudhury (Student)
TBA

Marci Rosenberg (Student)
TBA


April 11, 2019

Rhogerry Deshycka (Student)
TBA

Kirsten Chen (Student)
TBA


April 18, 2019

Daphne Superville (Student)
TBA

Raymond Dai (Student)
TBA


April 25, 2019

Gokul Ramadoss (Student)
TBA

Saumya Bollam (Student)
TBA


May 2, 2019

Rachel DeBarge (Student)
TBA

Nick Mroz (Student)
TBA


May 9, 2019

Benjamin Wheeler (Student)
TBA

Julie Cole (Student)
TBA


May 16, 2019

Megan Montoya (Student)
TBA

Brian Woo (Student)
TBA


May 23, 2019

Carlos Zuazo (Student)
TBA

Yewande Alabi (Student)
TBA


May 30, 2019

Bahar Zirak (Student)
TBA

Niko Eng (Student)
TBA


June 6, 2019

Jackson Gardner (Student)
TBA

Priscila Munoz Sandoval (Student)
TBA