2020-21 Journal Club Schedule
Dates:September 10th, 2020 - May 20th, 2021
Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Links to the live stream and recorded video are in the sidebar.
**COVID-19 UPDATE**
BMS Journal Club will be conducted via Zoom meeting until further notice. To watch live, join the meeting via the Zoom link sent out every week. You will also be able to ask questions of the presenters via Zoom. Please review our Zoom etiquette guidelines before joining the meeting.
The Zoom link and meeting password will be sent out to those on the BMS listservs the day of every journal club. Please contact Demian Sainz if you are not already on one of our listservs.
See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.
September 10, 2020
Mustafa Aydogan (Faculty)
"Organelle dynamics in non-dividing cells and their fate choice"
Iwata, R. et al. Mitochondrial dynamics in postmitotic cells regulate neurogenesis. Science 369(6505), 858-862. (2018).
Mariko Foecke (Student)
"Rewinding the Biological Clock: NMN Supplementation Reverses the Declining Quality of Maternally Aged Oocytes"
Miao Y, Cui Z, Gao Q, Rui R, Xiong B. Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes. Cell Rep. 2020;32(5):107987. doi:10.1016/j.celrep.2020.107987
Coaches: Diana Laird and Saul Villeda
September 17, 2020
Rong Wang (Faculty)
"It’s Smart to Make Friends with Blood Vessels"
Chow, B.W., Nuñez, V., Kaplan, L. et al. Caveolae in CNS arterioles mediate neurovascular coupling. Nature 579, 106–110 (2020). https://doi.org/10.1038/s41586-020-2026-1
Cambria Chou-Freed (Student)
"Rewinding the Biological Clock (Again): Can NAD+ Reverse Declining Circadian Rhythms with Age?"
Levine DC, Hong H, Weidemann BJ, et al. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. Mol Cell. 2020;78(5):835-849.e7. doi:10.1016/j.molcel.2020.04.010
Coaches: Louis Ptacek and Bassem Al-Sady
September 24, 2020
Martin Kampmann (Faculty)
"Shapeshifters to the rescue"
Qian et al. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582, 550–556 (2020).
Jacqueline Yee (Student)
"Is it fate? Single cell barcoding identifies a CD8 Trm-like precursor state before tissue entry"
Lianne Kok, Feline E. Dijkgraaf, Jos Urbanus, Kaspar Bresser, David W. Vredevoogd, Rebeca F. Cardoso, Leïla Perié, Joost B. Beltman, Ton N. Schumacher; A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool. J Exp Med 5 October 2020; 217 (10): e20191711. doi: https://doi.org/10.1084/jem.20191711
Coaches: Matt Spitzer and Shomyseh Sanjabi
October 1, 2020
Matthew Kutys (Faculty)
"Cell Find Their Own Way"
Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown Science 28 Aug 2020: https://science.sciencemag.org/content/369/6507/eaay9792/tab-pdf
Brandon Desousa (Student)
"Complex I: Up in Smoke"
Jimenez-Blasco, D. et al. Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature 2020, 583, 603–608.
Coaches: Martin Kampmann and Ken Nakamura
October 8, 2020
Isha Jain (Faculty)
"Pressing (Dia)Pause in Life"
Hu CK, Wang W, Brind'Amour J, et al. Vertebrate diapause preserves organisms long term through Polycomb complex members. Science. 2020;367(6480):870-874. doi:10.1126/science.aaw2601
Jessica Wang (Student)
"Innate Immune Cells Remember: PIRs mediate innate myeloid cell memory to nonself MHC molecules"
Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W, et al. PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science. 2020 Jun 5;368(6495):1122 LP – 1127. doi: 10.1126/science.aax4040
Coaches: James Gardner, Matt Spitzer, and Lewis Lanier.
October 15, 2020
Mark Moasser (Faculty)
"Towards a deeper understanding of HER2-HER3 signaling"
Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers. Choi et al. Elife 2020; 9: e53934.
Zach Howard (Student)
"The 2020 Census: Intratumor Bacteria Edition"
Nejman, D., et al. 2020. The human tumor microbiome is composed of tumor type–specific intracellular bacteria. Science, 368(6494), 973-980.
Coaches: Peter Turnbaugh and Rohit Bose
October 22, 2020
Alejandro Sweet-Cordero (Faculty)
"Using single cell genomics to define state transitions in lung cancer."
LaFave et al., Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma, Cancer Cell (2020), https://doi.org/10.1016/j.ccell.2020.06.006
Erin Huiting (Student)
“Float like a butterfly, sting like a bacteria: STING-mediated signaling pathway has ancestral origin in bacteria”
Morehouse BR et al. STING cyclic dinucleotide sensing originated in bacteria. Nature. (2020). https://doi.org/10.1038/s41586-020-2719-5
Coaches: Joe Bondy-Denomy and Oren Rosenberg
October 29, 2020
Rushika Perera (Faculty)
"The mechanics of metabolism"
Park, J.S., Burckhardt, C.J., Lazcano, R. et al. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature 578, 621–626 (2020). https://doi.org/10.1038/s41586-020-1998-1
Dianne Laboy Cintrón (Student)
"A tale of two fishes: Species-specific and conserved genomic response to regeneration"
Wang, W., Hu, C. K., Zeng, A., Alegre, D., Hu, D., Gotting, K., ... & Zhang, S. (2020). Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates. Science, 369(6508).
Coaches: Guo Huang and Nadav Ahituv
November 5, 2020
Julie Sneddon (Faculty)
"Designer Blood Vessels for Organ Formation & Regeneration"
Palikuqi, B., Nguyen, D.T., Li, G. et al. Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Nature 585, 426–432 (2020). https://doi.org/10.1038/s41586-020-2712-z
Oscar Yip (Student)
"Preventing spontaneous Alzheimer's disease: How an autophagy protein plays a role"
Heckmann, B. L., Teubner, B. J., Boada-Romero, E., Tummers, B., Guy, C., Fitzgerald, P., ... & Green, D. R. (2020). Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease. Science advances, 6(33), eabb9036.
Coaches: Jorge Palop and Martin Kampmann
November 12, 2020
Rohit Bose (Faculty)
"How the Making of Milk Or Saliva Might Become Lethal Adenocarcinoma"
Centonze A et al. Heterotypic cell-cell communication regulates glandular stem cell multipotency. Nature. 2020 Aug;584(7822):608-613.
Anthony Chang (Student)
"When you creep on fat, it creeps back."
Ha et al., Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans, Cell (2020), https://doi.org/10.1016/j.cell.2020.09.009
Coaches: Ari Molofsky and Peter Turnbaugh
November 19, 2020
Mark Seielstad (Faculty)
“Identifying Genetic Variation Influencing COVID-19 Disease Severity”
Qian Zhang, et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 Oct 23;370(6515):eabd4570. doi: 10.1126/science.abd4570. Epub 2020 Sep 24. PMID: 32972995.
Yashodara Abeykoon (Student)
"What makes us human?"
Evolution of regulatory signatures in primate cortical neurons at cell type resolution. AlexeyKozlenkov,Marit W.Vermunt,PashaApontes,JunhaoLi,KeHao,Chet C.Sherwood,Patrick R.Hof,John J.Ely,MichaelWegner,Eran A.Mukamel,Menno P.Creyghton,Eugene V.Koonin,StellaDracheva bioRxiv2020.07.24.219881;doi:https://doi.org/10.1101/2020.07.24.219881
Coaches: Alex Pollen and Elphege Nora
January 7, 2021
Ziad Jowhar (Student)
"Sequential Inverse Dysregulation of the RNA Helicases DDX3X and DDX3Y Facilitates MYC-Driven Lymphomagenesis"
Gong, Chun, et. al. Sequential Inverse Dysregulation of the RNA Helicases DDX3X and DDX3Y Facilitates MYC-Driven Lymphomagenesis. Available at SSRN: https://ssrn.com/abstract=3520953 or http://dx.doi.org/10.2139/ssrn.3520953
Coaches: Andrei Goga and Bill Weiss
Christopher Chang (Student)
"Examining mitochondrial fitness in tumor infiltrating lymphocytes"
Yu, YR., Imrichova, H., Wang, H. et al. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. Nat Immunol 21, 1540–1551 (2020). https://doi.org/10.1038/s41590-020-0793-3
Coaches: Justin Eyquem and Kole Roybal
January 14, 2021
Nicholas Carey (Student)
"Humoral Response to Chronic Viral Infection"
Fallet, B., Hao, Y., Florova, M., Cornille, K., de los Aires, A. V., Girelli Zubani, G., Ertuna, Y. I., Greiff, V., Menzel, U., Hammad, K., Merkler, D., Reddy, S. T., Weill, J.-C., Reynaud, C.-A., & Pinschewer, D. D. (2020). Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses. Cell Reports, 30(4), 1013-1026.e7. https://doi.org/10.1016/j.celrep.2019.12.023
Coaches: Jody Baron and Joe Bondy-Denomy
Shenghuan Sun (Student)
"The epigenetic alterations associated with Alzheimer’s disease"
Nativio, R., Lan, Y., Donahue, G. et al. An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease. Nat Genet 52, 1024–1035 (2020).
Coaches: Jingjing Li and Marina Sirota
January 21, 2021
Timmy Suh (Student)
"Tau disaggregation: Uncovering a novel form of frontotemporal degeneration"
Darwich, N. F., Phan, J. M., Kim, B., Suh, E., Papatriantafyllou, J. D., Changolkar, L., Nguyen, A. T., O'Rourke, C. M., He, Z., Porta, S., Gibbons, G. S., Luk, K. C., Papageorgiou, S. G., Grossman, M., Massimo, L., Irwin, D. J., McMillan, C. T., Nasrallah, I. M., Toro, C., Aguirre, G. K., … Lee, E. B. (2020). Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science (New York, N.Y.), 370(6519), eaay8826. https://doi.org/10.1126/science.aay8826
Coaches: Rohit Bose and Martin Kampmann
Sofia Caryotakis (Student)
"Neuroregenerative Neutrophils in CNS Injury"
Sas, A.R., Carbajal, K.S., Jerome, A.D. et al. A new neutrophil subset promotes CNS neuron survival and axon regeneration. Nat Immunol 21, 1496–1505 (2020). https://doi.org/10.1038/s41590-020-00813-0
Coaches: Michael Wilson and Susanna Rosi
January 28, 2021
Melanie Ott (Faculty)
"Vaccines versus Variants- are we winning the race?"
Wang et al. (Jan 19, 2021). MRNA Vaccine-Elicited Antibodies to SARS-CoV-2 and Circulating Variants. BioRxiv. https://doi.org/10.1101/2021.01.15.426911
Nebat Ali (Student)
"It's getting hot in here: GAG activates the inflammasome to provide host protection"
Briard, B., Fontaine, T., Samir, P. et al. Galactosaminogalactan activates the inflammasome to provide host protection. Nature 588, 688–692 (2020). https://doi.org/10.1038/s41586-020-2996-z
Coaches: Jason Cyster and Suzanne Noble
February 4, 2021
Molly Bassette (Student)
"Synergistic Cancer Immunotherapy: Does Teamwork Make the Dream Work?"
Srivastava, S., Furlan, S., Jaeger-Ruckstuhl, C., et al. Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade. Cancer Cell (2020). https://doi.org/10.1016/j.ccell.2020.11.005.
Coaches: Justin Eyquem and Michael McManus
Matt Arvedson (Student)
"Exploiting EBV signaling to bolster anti-lymphoma immunity"
Choi, I. K., Wang, Z., Ke, Q., Hong, M., Paul, D. W., Jr, Fernandes, S. M., Hu, Z., Stevens, J., Guleria, I., Kim, H. J., Cantor, H., Wucherpfennig, K. W., Brown, J. R., Ritz, J., & Zhang, B. (2020). Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature, 10.1038/s41586-020-03075-w.
Coaches: Jason Cyster and Chris Allen
February 11, 2021
Jason Cyster (Faculty)
“Immunology on the Mind, B cells on the Brain"
Fitzpatrick, Z., Frazer, G., Ferro, A. et al. Gut-educated IgA plasma cells defend the meningeal venous sinuses. Nature 587, 472–476 (2020). https://doi.org/10.1038/s41586-020-2886-4
Sophia Guldberg (Student)
"Tumor Tug-of-War: How Obesity is Helping Tumor Cells Win"
Ringel AE. et al. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020 Dec 23;183(7):1848-1866.e26. doi: 10.1016/j.cell.2020.11.009. Epub 2020 Dec 9. PMID: 33301708.
Coaches: Matt Spitzer and Rushika Perera
February 18, 2021
Jason Swinderman (Student)
"Returning to your Roots: ARID1A loss and lineage plasticity in ER+ breast cancer"
Xu, G., Chhangawala, S., Cocco, E. et al. ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nat Genet 52, 198–207 (2020). https://doi.org/10.1038/s41588-019-0554-0
Coaches: Daniel Lim and Asmin Tulpule
Xian Liu (Student)
"Thymic Treg RANKing high in pregnancy"
Paolino, M., Koglgruber, R., Cronin, S.J.F. et al. RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature (2020). https://doi.org/10.1038/s41586-020-03071-0
Coaches: James Gardner and Adrian Erlebacher
February 25, 2021
Kyle Jacobs (Student)
"Allegory of the Cave-ola: Turning our heads toward the causes of CCM"
Zhou, H.J., Qin, L., Jiang, Q. et al. Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Nat Commun 12, 504 (2021). https://doi.org/10.1038/s41467-020-20774-0
Coaches: Rong Wang and Matt Kutys
Gabi Reeder (Student)
“Sensing the World: Integrating the Mind and Body”
Siyi Huang, Carly G.K. Ziegler, John Austin, Najat Mannoun, Marko Vukovic, Jose Ordovas-Montanes, Alex K. Shalek, and Ulrich H. von Andrian. "Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential". Cell 184, 1–19, January 21, 2021.
Coaches: James Gardner and Tiffany Scharschmidt
March 4, 2021
Rachel Rock (Student)
"Sex, Age, and the Human Gut."
Zhang, X., Zhong, H., Li, Y. et al. Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities. Nat Aging 1, 87–100 (2021). https://doi.org/10.1038/s43587-020-00014-2
Coaches: Peter Turnbaugh and Anita Sil
Albert Xu (Student)
"Understanding mechanisms behind stress response"
Lamper AM, Fleming RH, Ladd KM, Lee ASY. A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress. Science. 2020 Nov 13;370(6518):853-856. doi: 10.1126/science.abb0993. PMID: 33184215.
Coaches: Peter Walter and Luke Gilbert
March 11, 2021
Zach Gardell (Student)
"Taking a page out of the embryonic playbook: Cancers repurpose diapause to persist through treatment"
Dhimolea, E., et al. An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence. Cancer Cell 2021, 0 (0). https://doi.org/10.1016/j.ccell.2020.12.002.
Coaches: Andrei Goga and Ryan Corces
Grace Hernandez (Student)
"Stanniocalcin stands in the way of effective APC-mediated phagocytosis by its interaction with mitochondrial Calreticulin in tumors"
Lin, H., Kryczek, I., Li, S., Green, M. D., Ali, A., Hamasha, R., Wei, S., Vatan, L., Szeliga, W., Grove, S., Li, X., Li, J., Wang, W., Yan, Y., Choi, J. E., Li, G., Bian, Y., Xu, Y., Zhou, J., Zou, W. (2021). Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance. Cancer Cell, 1–14. https://doi.org/10.1016/j.ccell.2020.12.023
Coaches: Jayanta Debnath and Matthew Krummel
March 25, 2021
Karen Tolentino (Student)
“There’s a Fungus Among Us: The Role of Type 1 Immunity in C. Albicans Infection.”
Break TJ, Oikonomou V, Dutzan N, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371(6526):eaay5731. doi:10.1126/science.aay5731
Coaches: Joel Ernst and Babak Javid
Joe Germino (Student)
"Redefining cancer: Utilizing extracellular biomarkers to identify tumors"
Hoshino A, Kim HS, Bojmar L, et al. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020;182(4):1044-1061.e18. doi:10.1016/j.cell.2020.07.009
Coaches: Robert Blelloch and Robert Raffai
April 1, 2021
Rhea Misra (Student)
"License to Ill: Identifying a novel subpopulation of anti-inflammatory astrocytes"
Sanmarco, L.M., Wheeler, M.A., Gutiérrez-Vázquez, C. et al. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature 590, 473–479 (2021). https://doi.org/10.1038/s41586-020-03116-4
Coaches: Susanna Rosi and Peter Turnbaugh
Demi Sandel (Student)
"The macrophage in the TME of TNBC: a double-edged sword"
Mehta, A.K., Cheney, E.M., Hartl, C.A. et al. Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.Nat Cancer 2, 66–82 (2021). https://doi.org/10.1038/s43018-020-00148-7
Coaches: Justin Eyquem and Rachel Rutishauser.
April 8, 2021
Mitchel Cole (Student)
"Epitranscriptomic Regulation of Oncogenes in Glioblastoma Models"
Dixit, D., Prager, B. C., Gimple, R. C., Poh, H. X., Wang, Y., Wu, Q., … Rich, J. N. (2021). The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells. Cancer Discovery, 11(2), 480–499. https://doi.org/10.1158/2159-8290.cd-20-0331
Coaches: Aaron Diaz and Hani Goodarzi
Maya Lopez-Ichikawa (Student)
"Transcriptional and epigenetic programs define CD8+ T cell differentiation"
Yao, Chen, et al. "BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells." Nature immunology (2021): 1-11
Coaches: Justin Eyquem and Matt Spitzer
April 15, 2021
Megan Scantlen (Student)
"C8G, a new player in neuroinflammation"
Jong-Heon Kim, Ruqayya Afridi, Jin Han, Hyun-Gug Jung, Seung-Chan Kim, Eun Mi Hwang, Hyun Soo Shim, Hoon Ryu, Youngshik Choe, Hyang-Sook Hoe, Kyoungho Suk, Gamma subunit of complement component 8 is a neuroinflammation inhibitor, Brain, Volume 144, Issue 2, February 2021, Pages 528–552, https://doi.org/10.1093/brain/awaa425
Coaches: Jeanne Paz and Saul Villeda
Maya Arce (Student)
"Probing the molecular mechanisms of IFN-γ induced resistance to tumor immunotherapy"
Yu M, Peng Z, Qin M, Liu Y, Wang J, Zhang C, Lin J, Dong T, Wang L, Li S, Yang Y, Xu S, Guo W, Zhang X, Shi M, Peng H, Luo X, Zhang H, Zhang L, Li Y, Yang XP, Sun S. Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation. Mol Cell. 2021 Feb 13:S1097-2765(21)00010-1. doi: 10.1016/j.molcel.2021.01.010. Epub ahead of print. PMID: 33606996.
Coaches: Cliff Lowell and Rohit Bose
April 22, 2021
Laura Dwyer (Student)
"Early life antibiotic exposure and impacts on growth"
Uzan-Yulzari, A., Turta, O., Belogolovski, A. et al. Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization. Nat Commun 12, 443 (2021). https://doi.org/10.1038/s41467-020-20495-4
Coaches: Peter Turnbaugh and Cliff Lowell
Cuyler Luck (Student)
"Circular reasoning" in AML
Wang X, Jin P, Zhang Y, & Wang K. "CircSPI1 acts as an oncogene in acute myeloid leukemia through antagonizing SPI1 and interacting with microRNAs." Cell Death & Disease, 12: 297.
Coaches: Cathy Smith and Rohit Bose
April 29, 2021
Laine Goudy (Student)
"Exploring Multimodal Parameters in Cancer Immune Evasion"
Frangieh CJ, Melms JC, Thakore PI, Geiger-Schuller KR, Ho P, Luoma AM, et al. Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion. Nat Genet. 2021 Mar;53(3):332–41.
Coaches: Justin Eyquem and Michael McManus
Iris Chin (Student)
"Early life stress leaves its (epigenetic) mark on the brain to drive future stress susceptibility"
Kronman, H., Torres-Berrío, A., Sidoli, S. et al. Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons. Nat Neurosci (2021). https://doi.org/10.1038/s41593-021-00814-8
Coaches: Yin Shen and Dev Manoli
May 6, 2021
Hannah Driks (Student)
"Two sides to every story: A new role for MDM2 in anti-tumor immunity"
Zhou, J., Kryczek, I., Li, S. et al. The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity. Nat Immunol (2021). https://doi.org/10.1038/s41590-021-00888-3
Coaches: Hideho Okada and Justin Eyquem
Owen Jiang (Student)
“Hold T cell responsible: CD8 cells worsen anti-PD1 treatment outcome in NASH-driven HCC.”
Pfister, D., Núñez, N.G., Pinyol, R. et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature (2021). https://doi.org/10.1038/s41586-021-03362-0
Coaches: Emily Goldberg and Sagar Bapat
May 13, 2021
Marilyn Steyert (Student)
"You have your mother's barcode: Imaging cell lineage with a synthetic digital recording system"
Chow, K. H. K., Budde, M. W., Granados, A. A., Cabrera, M., Yoon, S., Cho, S., ... & Elowitz, M. B. (2021). Imaging cell lineage with a synthetic digital recording system. Science, 372(6538).
Coaches: Tomasz Nowakowski and Alex Pollen
Juliana Sucharov Costa (Student)
"Teaching an old brain new immune tricks: targeting aged myeloid cell metabolism rescues cognition"
Minhas, P.S., Latif-Hernandez, A., McReynolds, M.R. et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature 590, 122–128 (2021). https://doi.org/10.1038/s41586-020-03160-0
Coaches: Anna Molofsky and Max Krummel
May 20, 2021
Min Joo Kim (Student)
"Double Trouble: Whole Genome Duplications in Cancer Vulnerabilities"
Quinton, Ryan J., et al. "Whole-genome doubling confers unique genetic vulnerabilities on tumour cells." Nature 590.7846 (2021): 492-497. https://www.nature.com/articles/s41586-020-03133-3
Coaches: Isha Jain and Joe Costello