2020-21 Journal Club Schedule
Dates:September 10th, 2020 - May 20th, 2021
Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Links to the live stream and recorded video are in the sidebar.
**COVID-19 UPDATE**
BMS Journal Club will be conducted via Zoom meeting until further notice. To watch live, join the meeting via the Zoom link sent out every week. You will also be able to ask questions of the presenters via Zoom. Please review our Zoom etiquette guidelines before joining the meeting.
The Zoom link and meeting password will be sent out to those on the BMS listservs the day of every journal club. Please contact Demian Sainz if you are not already on one of our listservs.
See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.
September 10, 2020
Mustafa Aydogan (Faculty)
"Organelle dynamics in non-dividing cells and their fate choice"
Iwata, R. et al. Mitochondrial dynamics in postmitotic cells regulate neurogenesis. Science 369(6505), 858-862. (2018).
Mariko Foecke (Student)
"Rewinding the Biological Clock: NMN Supplementation Reverses the Declining Quality of Maternally Aged Oocytes"
Miao Y, Cui Z, Gao Q, Rui R, Xiong B. Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes. Cell Rep. 2020;32(5):107987. doi:10.1016/j.celrep.2020.107987
Coaches: Diana Laird and Saul Villeda
September 17, 2020
Rong Wang (Faculty)
"It’s Smart to Make Friends with Blood Vessels"
Chow, B.W., Nuñez, V., Kaplan, L. et al. Caveolae in CNS arterioles mediate neurovascular coupling. Nature 579, 106–110 (2020). https://doi.org/10.1038/s41586-020-2026-1
Cambria Chou-Freed (Student)
"Rewinding the Biological Clock (Again): Can NAD+ Reverse Declining Circadian Rhythms with Age?"
Levine DC, Hong H, Weidemann BJ, et al. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. Mol Cell. 2020;78(5):835-849.e7. doi:10.1016/j.molcel.2020.04.010
Coaches: Louis Ptacek and Bassem Al-Sady
September 24, 2020
Martin Kampmann (Faculty)
"Shapeshifters to the rescue"
Qian et al. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582, 550–556 (2020).
Jacqueline Yee (Student)
"Is it fate? Single cell barcoding identifies a CD8 Trm-like precursor state before tissue entry"
Lianne Kok, Feline E. Dijkgraaf, Jos Urbanus, Kaspar Bresser, David W. Vredevoogd, Rebeca F. Cardoso, Leïla Perié, Joost B. Beltman, Ton N. Schumacher; A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool. J Exp Med 5 October 2020; 217 (10): e20191711. doi: https://doi.org/10.1084/jem.20191711
Coaches: Matt Spitzer and Shomyseh Sanjabi
October 1, 2020
Matthew Kutys (Faculty)
"Cell Find Their Own Way"
Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown Science 28 Aug 2020: https://science.sciencemag.org/content/369/6507/eaay9792/tab-pdf
Brandon Desousa (Student)
"Complex I: Up in Smoke"
Jimenez-Blasco, D. et al. Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature 2020, 583, 603–608.
Coaches: Martin Kampmann and Ken Nakamura
October 8, 2020
Isha Jain (Faculty)
"Pressing (Dia)Pause in Life"
Hu CK, Wang W, Brind'Amour J, et al. Vertebrate diapause preserves organisms long term through Polycomb complex members. Science. 2020;367(6480):870-874. doi:10.1126/science.aaw2601
Jessica Wang (Student)
"Innate Immune Cells Remember: PIRs mediate innate myeloid cell memory to nonself MHC molecules"
Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W, et al. PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science. 2020 Jun 5;368(6495):1122 LP – 1127. doi: 10.1126/science.aax4040
Coaches: James Gardner, Matt Spitzer, and Lewis Lanier.
October 15, 2020
Mark Moasser (Faculty)
"Towards a deeper understanding of HER2-HER3 signaling"
Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers. Choi et al. Elife 2020; 9: e53934.
Zach Howard (Student)
"The 2020 Census: Intratumor Bacteria Edition"
Nejman, D., et al. 2020. The human tumor microbiome is composed of tumor type–specific intracellular bacteria. Science, 368(6494), 973-980.
Coaches: Peter Turnbaugh and Rohit Bose
October 22, 2020
Alejandro Sweet-Cordero (Faculty)
"Using single cell genomics to define state transitions in lung cancer."
LaFave et al., Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma, Cancer Cell (2020), https://doi.org/10.1016/j.ccell.2020.06.006
Erin Huiting (Student)
“Float like a butterfly, sting like a bacteria: STING-mediated signaling pathway has ancestral origin in bacteria”
Morehouse BR et al. STING cyclic dinucleotide sensing originated in bacteria. Nature. (2020). https://doi.org/10.1038/s41586-020-2719-5
Coaches: Joe Bondy-Denomy and Oren Rosenberg
October 29, 2020
Rushika Perera (Faculty)
"The mechanics of metabolism"
Park, J.S., Burckhardt, C.J., Lazcano, R. et al. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature 578, 621–626 (2020). https://doi.org/10.1038/s41586-020-1998-1
Dianne Laboy Cintrón (Student)
"A tale of two fishes: Species-specific and conserved genomic response to regeneration"
Wang, W., Hu, C. K., Zeng, A., Alegre, D., Hu, D., Gotting, K., ... & Zhang, S. (2020). Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates. Science, 369(6508).
Coaches: Guo Huang and Nadav Ahituv
November 5, 2020
Julie Sneddon (Faculty)
"Designer Blood Vessels for Organ Formation & Regeneration"
Palikuqi, B., Nguyen, D.T., Li, G. et al. Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Nature 585, 426–432 (2020). https://doi.org/10.1038/s41586-020-2712-z
Oscar Yip (Student)
"Preventing spontaneous Alzheimer's disease: How an autophagy protein plays a role"
Heckmann, B. L., Teubner, B. J., Boada-Romero, E., Tummers, B., Guy, C., Fitzgerald, P., ... & Green, D. R. (2020). Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease. Science advances, 6(33), eabb9036.
Coaches: Jorge Palop and Martin Kampmann
November 12, 2020
Rohit Bose (Faculty)
"How the Making of Milk Or Saliva Might Become Lethal Adenocarcinoma"
Centonze A et al. Heterotypic cell-cell communication regulates glandular stem cell multipotency. Nature. 2020 Aug;584(7822):608-613.
Anthony Chang (Student)
"When you creep on fat, it creeps back."
Ha et al., Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans, Cell (2020), https://doi.org/10.1016/j.cell.2020.09.009
Coaches: Ari Molofsky and Peter Turnbaugh
November 19, 2020
Mark Seielstad (Faculty)
“Identifying Genetic Variation Influencing COVID-19 Disease Severity”
Qian Zhang, et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 Oct 23;370(6515):eabd4570. doi: 10.1126/science.abd4570. Epub 2020 Sep 24. PMID: 32972995.
Yashodara Abeykoon (Student)
"What makes us human?"
Evolution of regulatory signatures in primate cortical neurons at cell type resolution. AlexeyKozlenkov,Marit W.Vermunt,PashaApontes,JunhaoLi,KeHao,Chet C.Sherwood,Patrick R.Hof,John J.Ely,MichaelWegner,Eran A.Mukamel,Menno P.Creyghton,Eugene V.Koonin,StellaDracheva bioRxiv2020.07.24.219881;doi:https://doi.org/10.1101/2020.07.24.219881
Coaches: Alex Pollen and Elphege Nora
January 7, 2021
Ziad Jowhar (Student)
TBD
Christopher Chang (Student)
TBD
January 14, 2021
Nicholas Carey (Student)
TBD
Shenghuan Sun (Student)
TBD
January 21, 2021
Timmy Suh (Student)
TBD
Sofia Caryotakis (Student)
TBD
January 28, 2021
Faculty
TBD
Nebat Ali (Student)
TBD
February 4, 2021
Molly Bassette (Student)
TBD
Matt Arvedson (Student)
TBD
February 11, 2021
Jason Cyster (Faculty)
TBD
Sophia Guldberg (Student)
TBD
February 18, 2021
Jason Swinderman (Student)
TBD
Xian Liu (Student)
TBD
February 25, 2021
Kyle Jacobs (Student)
TBD
Gabi Reeder (Student)
TBD
March 4, 2021
Rachel Rock (Student)
TBD
Albert Xu (Student)
TBD
March 11, 2021
Zach Gardell (Student)
TBD
Grace Hernandez (Student)
TBD
March 25, 2021
Karen Tolentino (Student)
TBD
Joe Germino (Student)
TBD
April 1, 2021
Rhea Misra (Student)
TBD
Demi Sandel (Student)
TBD
April 8, 2021
Mitchel Cole (Student)
TBD
Maya Lopez-Ichikawa (Student)
TBD
April 15, 2021
Megan Scantlen (Student)
TBD
Maya Arce (Student)
TBD
April 22, 2021
Laura Dwyer (Student)
TBD
Cuyler Luck (Student)
TBD
April 29, 2021
Laine Goudy (Student)
TBD
Iris Chin (Student)
TBD
May 6, 2021
Hannah Driks (Student)
TBD
Owen Jiang (Student)
TBD
May 13, 2021
Marilyn Steyert (Student)
TBD
Juliana Sucharov Costa (Student)
TBD
May 20, 2021
Min Joo Kim (Student)
TBD