2019-20 Journal Club Schedule
Dates: September 5, 2019 - May 21, 2020
Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room MH-1405, Mission Bay.
Links to the live stream and recorded video are in the sidebar.
**If you're watching the video stream at Mission Bay and would like to ask the speaker a question, send a DM via Twitter to @UCSF_BMS_JC and someone at Parnassus will ask your question for you.
See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.
September 5, 2019
Mary Helen Barcellos-Hoff (faculty)
"Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts"
10.1158/2159-8290.CD-19-0094 Published August 2019
Gokul Ramadoss (student)
"Careful Cas9 Cutting Cures Condemned Cochleas"
György et al. Allele-specific gene editing prevents deafness in a model of
dominant progressive hearing loss. Nat Med. 2019 Jul;25(7):1123-1130. doi:
10.1038/s41591-019-0500-9. Epub 2019 Jul 3.
Coaches: Aaron Tward and Bruce Conklin
September 12, 2019
Jeoung-Sook Shin (faculty)
"Role of protein crystallization in asthma"
Persson et al., 'Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.' Science. 2019 May 24;364(6442). pii: eaaw4295. doi: 10.1126/science.aaw4295.
Raymond Dai (student)
"A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies"
Boettcher, S. et al. (2019). A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science 365 (6453), 599-604. doi: 10.1126/science.aax3649
Coaches: Joe Costello and Kevin Shannon
September 19, 2019
Isha Jain (faculty)
"The Treasure Hunt for New Oxygen Sensors"
Masson et al., ‘Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.’ Science. 2019 Jul 5;365(6448):65-69. doi: 10.1126/science.aaw0112.
Yewande Alabi (student)
"Phase separation and nuclear protein quality control: How the nucleolus promotes nuclear protein maintenance under stress"
Frottin, F. et al. (2019). The nucleolus functions as a phase-separated protein quality control compartment. Science. doi: 10.1126/science.aaw9157
Coaches: Bill DeGrado and Aimee Kao
September 26, 2019
Stephen Floor (faculty)
"This is your brain on lipoic acid: small molecule control of phase separation and neurodegeneration."
Wheeler, R. et al. 'Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease.' doi:10.1101/721001
Carlos Zuazo (student)
"Dreams From My Father: Neuronal Small RNAs Control Behavior Transgenerationally."
Posner et al. 'Neuronal Small RNAs Control Behavior Transgenerationally.' Cell 177, 1814–1826. June 13, 2019.
Coaches: Shaeri Mukherjee and Stephen Floor
October 3, 2019
Rohit Bose (faculty)
"Reversing oncogenic differentiation: can Humpty Dumpty be put together again?"
Walter et al., 'RB constrains lineage fidelity and multiple stages of tumour progression and metastasis' Nature volume 569, pages 423–427 (2019).
Kirsten Chen (student)
"An Emerging Panacea in Our Bodies - Microbiome"
Scheiman et al., 'Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism', Nature Medicine 25, 1104–1109 (2019)
Coaches: Katie Pollard and Peter Turnbaugh
October 10, 2019
Sophie Dumont (faculty)
"How mammalian oocytes build a spindle without centrosomes"
So et al., A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes. Science, Jun 28; 364. (2019).
Megan Montoya (student)
"Immune-suppressive tumor microenvironment leads to poor prognosis in Glioblastoma patients"
Alban et al., Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis. JCI Insight. 2018;3(21):e122264
Coaches: Hideho Okada and Noriyuki Kasahara
October 17, 2019
Martin Kampmann (faculty)
"When the Powerhouse crumbles …"
Joshi et al (2019). Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nature Neuroscience 22:1635.PMID: 31551592.
Priscila Munoz Sandoval (student)
"Oh! That's where (T)hey went:"
Collins, N. et al. The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction. Cell (2019). doi:10.1016/j.cell.2019.07.049
Coaches: Mark Ansel & Jason Cyster
October 24, 2019
Andy Chang (faculty)
"What worms getting high can tell us about opioid signaling."
Wang et al., Genetic behavioral screen identifies an orphan anti-opioid system. Nature, Sep 20; 365(6459): 1267-1273 (2019).
Darwin Kwok (student)
"Connecting the Nodes Behind Gliomas: Electrical and synaptic integration of glioma into neural circuits."
Venkatesh et al. "Electrical and synaptic integration of glioma into neural circuits" Nature 573, 539-545 (September 18, 2019).
Coaches: David Raleigh and Erik Ullian
October 31, 2019
Elliott Sherr (faculty)
"A gene for you, a gene for me?"
J. Kim et al. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. October 24, 2019. N Engl J Med 2019; 381:1644-1652
Bahar Zirak (student)
"Tumor Heterogeneity and Immune Response in Melanoma"
Wolf et al. UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma. 2019, Cell 179, 219–235.
Coaches: Melissa Reeves and Rohit Bose
November 7, 2019
Elphege Nora (faculty)
"The Energetics and Physiological Impact of Cohesin Extrusion."
Vian, Pękowska, Rao et al., The Energetics and Physiological Impact of Cohesin Extrusion. Cell 2018, May 17;173(5):1165-1178.e20.
November 14, 2019
Bjoern Schwer (faculty)
"To live longer, give your neurons some REST"
Zullo et al., Regulation of lifespan by neural excitation and REST. Nature, 574, pages 359–364 (2019).
Adam Wade-Vallance (student)
"There's just enough material here for a broadly-neutralizing vaccine."
Sangesland M et al. Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus. Immunity. 2019;51(4):735-49.
Coach: Chris Allen and Julie Zikherman
November 21, 2019
Valerie Weaver (faculty)
"Sometimes being fat is a good thing"
Dana Ishay-Ronen et al. Gain fat - Lose metastasis: Converting invasive breast cancer cells into adipocytes inhibits cancer metastasis. Cancer Cell 35, 17-32 2019
Nour Abdulhay (student)
"The Tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals."
Chavez et al., The Tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals. eLife 2019;8:e47682
Coaches: Noelle L'Etoile and Elphege Nora
January 9, 2020
David Solomon (faculty)
"Epigenomic-based classification of human cancer"
Capper D. et al. DNA methylation-based classification of central nervous system tumours. Nature. 2018 Mar 22;555(7697):469-474. doi: 10.1038/nature26000. Epub 2018 Mar 14.
Saumya Bollam (student)
"Divide and conquer: Inhibition of tumor growth by a novel engineered chimeric toxin that cleaves activated mutant and wild-type RAS"
Vidimar, V. et al. (2019). Inhibition of tumor growth by a novel engineered chimeric toxin that cleaves activated mutant and wild-type RAS. bioRxiv. doi: https://doi.org/10.1101/2019.12.17.880187
Coaches: Allan Balmain and Luke Gilbert
January 16, 2020
David Raleigh (faculty)
“Pediatric Rhabdoid Tumors: Genomically boring, immunologically interesting, and (thankfully) really rare.”
Leruste A. et al. Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors. Cancer Cell. 2019 Dec 9;36(6):597-612.e8. doi: 10.1016/j.ccell.2019.10.008. Epub 2019 Nov 7.
Rhogerry Deshycka (student)
"Prime Editing: 'Search-and-replace' genome editing with enhanced efficiency, precision and coverage"
Anzalone et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature 576, 149–157 (2019) doi:10.1038/s41586-019-1711-4
Coaches: Stephen Floor and Luke Gilbert
January 23, 2020
* Note: Special Time and Location - 4:00 pm - Genentech Auditorium*
** BMS RECRUITMENT WEEKEND **
Alejandro Sweet-Cordero (faculty)
"Bridging the gap: linking genomic instability to immunotherapy."
Zhang, H. et al. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2020 Jan 13;37(1):37-54.e9. doi: 10.1016/j.ccell.2019.11.003. Epub 2019 Dec 26.
Daphne Superville (student)
"Kicking out the comp53tition: p53 mutant cells outcompeted in normal esophagus by redox manipulation"
Fernandez-Antoran, David, et al. “Outcompeting P53-Mutant Cells in the Normal Esophagus by Redox Manipulation.” Cell Stem Cell, vol. 25, no. 3, 2019, pp. 329–41, doi:10.1016/j.stem.2019.06.011.
Coaches: Melissa Reeves and Mary Helen Barcellos-Hoff
January 30, 2020
Diana Laird (faculty)
"The early worm gets the H3K4me3: larval oxidation state determines lifelong resilience via SET1/MLL histone methyltransferases"
Bazopoulou, D. et al. Developmental ROS individualizes organismal stress resistance and lifespan. Nature. 2019 Dec;576(7786):301-305. doi: 10.1038/s41586-019-1814-y. Epub 2019 Dec 4.
Brian Woo (student)
TBD
February 6, 2020
* Note: Special Time and Location - 4:00 pm - Genentech Auditorium*
** BMS RECRUITMENT WEEKEND **
Alex Marson (faculty)
TBD
Julie Garcia (student)
TBD
Strauss L, Mahmoud MAA, Weaver JD, et al. Targeted deletion of PD-1 in myeloid cells induces antitumor immunity. Sci Immunol. 2020;5(43). doi:10.1126/sciimmunol.aay1863
Coaches: Kole Roybal and Justin Eyquem
February 13, 2020
Ed Hsiao (faculty)
TBD
Nick Mroz (student)
TBD
February 20, 2020
Abby Buchwalter (faculty)
TBD
Vikas Daggubati (student)
TBD
February 27, 2020
Yashodara Abeykoon (student)
TBD
Than Kyaw (student)
TBD
March 5, 2020
Oscar Yip (student)
TBD
Irek Habrylo (student)
TBD
March 12, 2020
Nebat Ali (student)
TBD
Matt Ryan (student)
TBD
March 19, 2020
Alyssa Indart (student)
TBD
Jackson Gardner (student)
TBD
March 26, 2020
Rachel DeBarge (student)
TBD
Ben Wheeler (student)
TBD
April 2, 2020
Jacqueline Yee (student)
TBD
Anthony Chang (student)
TBD
April 9, 2020
Cambria Chou-Freed (student)
TBD
Jessica Wang (student)
TBD
April 16, 2020
Brandon Desousa (student)
TBD
Nicole Tsai (student)
TBD
April 23, 2020
Mariko Foecke (student)
TBD
Sonia Scaria (student)
TBD
April 30, 2020
Sophie Guldberg (student)
TBD
Dianne Laboy Cintron (student)
TBD
May 7, 2020
Zach Howard (student)
TBD
Erin Huiting (student)
TBD
May 14, 2020
Niko Eng (student)
"L1 and B1 repeats blueprint the spatial organization of Chromatin"
Lu, J. Yuyang et al., L1 and B1 repeats blueprint the spatial organization of chromatin. bioRxiv, October 13, 2019. doi:10.1101/802173
Coach: Daniele Canzio