2021-22 Journal Club Schedule
Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Links to the live stream and recorded video are in the sidebar.
**COVID-19 UPDATE**
As of 10/14/2021, Journal Club will be conducted via Zoom to meet COVID-19 social distancing requirements.
To watch remotely, join the meeting via the Zoom link sent out every week. You will also be able to ask questions of the presenters via Zoom. Please review our Zoom etiquette guidelines before joining the meeting.
The Zoom link and meeting password will be sent out to those on the BMS listservs the day of every journal club. Please contact Demian Sainz if you are not already on one of our listservs.
See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.
September 9, 2021
*Introduction to Journal Club with JC Chairs Bruce Wang and Tien Peng*
Dave Toczyski, Ph.D. (Faculty)
“Mitocytosis: Cells leave a trail of organellar jetsam”
Jaio et al, “Mitocytosis, a migrasome-mediated mitochondrial quality-control process.” 2021 Cell May 27: 184(11):2896-2910.e13.
Joe Germino (Student)
"Expanding the throughput of single cell transcriptomics via combinatorial preindexing"
Datlinger, P., Rendeiro, A.F., Boenke, T. et al. Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing. Nat Methods18, 635–642 (2021).
Coaches: Vasilis Ntranos, Ph.D. and Jimmie Ye, Ph.D.
September 16, 2021
Elphege-Pierre Nora, Ph.D. (Facutly)
"Nonlinear control of transcription through enhancer-promoter interactions"
Jessica Zuin, Gregory Roth, Yinxiu Zhan, Julie Cramard, Josef Redolfi, Ewa Piskadlo, Pia Mach, Mariya Kryzhanovska, Gergely Tihanyi, Hubertus Kohler, View ORCID ProfilePeter Meister, Sebastien Smallwood, Luca Giorgetti
Gabi Reeder (Student)
"Painting the chromatin landscape for optimal CAR T cell function"
Seo, H., González-Avalos, E., Zhang, W. et al. BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells. Nat Immunol 22, 983–995 (2021).
Coaches: Justin Eyquem, Ph.D. and Rachel Rutishauser, M.D., Ph.D.
September 23, 2021
Shaeri Mukherjee, Ph.D. (Faculty)
"Traveling waves: how bacterial pathogens rewire host membranes"
Hsieh, Ting-Sung, Lopez, Victor A., Black, Miles H., et al. Science. 2021 May 28;372(6545):935-941.
Marilyn Steyert (Student)
"Could've had a V1: Vision is required for cell-type specification in the visual cortex"
Cheng, S., Butrus, S., Xu, V., Sagireddy, S., Tan, L., Shekhar, K., & Zipursky, S. L. (2021). Vision is Required for Cell Type Specification in the Visual Cortex. bioRxiv.
Coaches: Tomasz Nowakowski, Ph.D. and Michael Oldham, Ph.D.
September 30, 2021
Thea Mauro, M.D. (Facutly)
Ode to Salt: Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity.
András Maifeld, Johannes Wild, Tine V. Karlsen,et al. Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity, Journal of Investigative Dermatology, 2021,ISSN 0022-202X, https://doi.org/10.1016/j.jid.2021.06.013.
Rachel Rock (Student)
GUT MICROBE RESEARCHER CLICKBAIT!!!!!!!
Han, S., Van Treuren, W., Fischer, C.R. et al. A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature 595, 415–420 (2021). https://doi.org/10.1038/s41586-021-03707-9
Coaches: Peter Turnbaugh, Ph.D. and Shaeri Mukherjee, Ph.D
October 7, 2021
Tammy T. Chang, M.D., Ph.D. (Facutly)
"Organoids are the future of transplantation"
Sampaziotis F, Muraro D, Tysoe OC, et al. Cholangiocyte organoids can repair bile ducts after transplantation in the human liver. Science (New York, N.Y.). 2021 Feb;371(6531):839-846. DOI: 10.1126/science.aaz6964.
Maya Arce (Student)
"Searching far and wide: Identification of functional SNPs and their ties to heritable traits"
Võsa, U., Claringbould, A., Westra, HJ. et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat Genet 53, 1300–1310 (2021). https://doi.org/10.1038/s41588-021-00913-z
Coaches: Marina Sirota, Ph.D. and Lauren Weiss, Ph.D
October 14, 2021
Aaron Tward, M.D., Ph.D. (Facutly)
“Towards the holy (en)grail of mammalian tissue regeneration”
Maksim V. Plikus, et al. Fibroblasts: Origins, definitions, and functions in health and disease, Cell, 184, 15, (3852-3872), (2021). https://www.science.org/doi/10.1126/science.abi5770
Shenghuan Sun (Student)
"From Brain to Information: single-cell level integrative multi-omics studies"
Morabito, S., Miyoshi, E., Michael, N. et al. Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease. Nat Genet 53, 1143–1155 (2021). https://doi.org/10.1038/s41588-021-00894-z
Coach: Ryan Corces, Ph.D. and Zicheng Hu, Ph.D.
October 21, 2021
Journal Club this week has been rescheduled so the community can attend the Chancellor’s State of the University Address.
October 28, 2021
Qili Liu, Ph.D. (Faculty)
"The microbiome-gut-brain axis and protein hunger"
Kim, B., Kanai, M.I., Oh, Y. et al. Response of the microbiome–gut–brain axis in Drosophila to amino acid deficit. Nature 593, 570–574 (2021). https://doi.org/10.1038/s41586-021-03522-2
Timmy Suh (Student)
"Single-cell Ribo-seq: Resolving the translatome at the cellular level to illuminate differential regulatory dynamics"
VanInsberghe, M., van den Berg, J., Andersson-Rolf, A., Clevers, H., & van Oudenaarden, A. (2021). Single-cell Ribo-seq reveals cell cycle-dependent translational pausing. Nature, 597(7877), 561–565. https://doi.org/10.1038/s41586-021-03887-4
November 4, 2021
Jayanta Debnath, M.D. (Faculty)
"Phase separation of glycogen and liver cancer"
Liu et al (2021). Glycogen accumulation and phase separation drives liver tumor initiation. Cell. 184, 1–18. Online ahead of print. Oct 21 2021. https://doi.org/10.1016/j.cell.2021.10.00
Molly Bassette (Student)
TBD
Del Pogetto, E., et al. (2021). Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science, 373(6561). https://doi.org/10.1126/science.abj0486.
Coaches: Karin Pelka, Ph.D. and Max Krummel, Ph.D.
November 18, 2021
Hannah Driks (Student)
"Lessons in self-control: CD8+ T cells release self-suppressing extracellular vesicles during inflammation"
Schneider, E., Winzer, R., Rissiek, A. et al. CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression. Nat Commun 12, 5911 (2021).
Coaches: Melissa Reeves, Ph.D. and Rushika Perera, Ph.D.
December 2, 2021
Zach Gardell (Student)
"A RoadMAP for MAPT"
Bowles, K. R. et al. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell 184, 4547-4563.e17 (2021).
Coaches: Tom Nowakowski, PhD and Yadong Huang, MD, PhD
Nicholas Carey (Student)
“PANINI MIBI: Melting Together Protein & Nucleic Acid Imaging”
Virus-Dependent Immune Conditioning of Tissue Microenvironments
Sizun Jiang, Chi Ngai Chan, Xavier Rovira-Clave, Han Chen, Yunhao Bai, Bokai Zhu, Erin McCaffrey, Noah F. Greenwald, Candace Liu, Graham L Barlow, Jason L.Weirather, John Paul Oliveria, Darci Philips, Nilanjan Mukherjee, Kathleen Busman-Sahay, Michael Nekorchuk, Margaret Terry, Skyler Younger, Marc Bosse, JanosDemeter, Yury Golstev, David Robert McIlwain, Michael Angelo, Jacob D. Estes, Garry P. Nolan
bioRxiv 2021.05.21.444548
Coaches: Rachel Rutishauser, MD, PhD and Nadia Roan, PhD
December 9, 2021
Megan Scantlen (Student)
TBD
Sofia Caryotakis (Student)
TBD
Sakamoto, K., Jin, S. P., Goel, S., Jo, J. H., Voisin, B., Kim, D., Nadella, V., Liang, H., Kobayashi, T., Huang, X., Deming, C., Horiuchi, K., Segre, J. A., Kong, H. H., & Nagao, K. (2021). Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction. Immunity, 54(10), 2321–2337.e10.
Coaches: Tiffany Scharschmidt, MD, PhD, and Ari Molofsky, PhD
January 6, 2022
Amy Chen (Student)
TBD
Hanson Tam (Student)
TBD
January 13, 2022
Holly Steininger (Student)
TBD
Meagan Olive (Student)
TBD
January 20, 2022
Iris Chin (Student)
TBD
TBD (Student)
January 27, 2022
TBD (Student)
Grace Hernandez (Student)
TBD
February 3, 2022
Demi Sandel (Student)
TBD
Laura Dwyer (Student)
TBD
February 10, 2022
Max Krummel, Ph.D. (Faculty)
TBD
Maya Lopez-Ichikawa (Student)
TBD
February 17, 2022
Laine Goudy (Student)
TBD
Rhea Misra (Student)
TBD
February 24, 2022
Cuyler Luck (Student)
TBD
Kyle Jacobs (Student)
TBD
March 3, 2022
Owen Jiang (Student)
TBD
Juliana Sucharov Costa (Student)
TBD
March 10, 2022
Mary Clare Beytagh (Student)
TBD
Nav Lally (Student)
TBD
March 17, 2022
Min Joo Kim (Student)
TBD
Xian Liu (Student)
TBD
March 24, 2022
Jun Hyung Sin (Student)
TBD
Caroline Whitty (Student)
TBD
March 31, 2022
Nathan Ewing-Crystal (Student)
TBD
Kadellyn Sandoval Gutierrez (Student)
TBD
April 7, 2022
Kevin Ly (Student)
TBD
Max Foisey (Student)
TBD
April 14, 2022
Wendy Hung (Student)
TBD
Kevin Chen (Student)
TBD
April 21, 2022
Li Wang (Student)
TBD
Margaret Gadek (Student)
TBD
April 28, 2022
Julianne Riggs (Student)
TBD
Zack Mullin-Bernstein (Student)
TBD
May 5, 2022
Letitia Yang (Student)
TBD
Kaylee Wedderburn-Pugh (Student)
TBD
May 12, 2022
Lexi Schneider (Student)
TBD
Charlotte Wang (Student)
TBD
May 19, 2022
Tori Tran (Student)
TBD
Rita Loudermilk (Student)
TBD
May 26, 2022
Kyla Foster (Student)
TBD
Isabelle Young (Student)
TBD
June 2, 2022
Max Pass (Student)
TBD
Jingwen Ding (Student)
TBD
June 9, 2022
Evan Semenza (Student)
TBD
William Xie (Student)
TBD
June 16, 2022
TBD (Faculty)
Matt Arvedson (Student)
“Do these Tregs make me look fat? Adipose Tregs are composed of distinct subsets that contribute to age and obesity related metabolic disorders”
Li, Y., Lu, Y., Lin, SH. et al. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol 22, 1175–1185 (2021). https://doi.org/10.1038/s41590-021-01010-3
Coaches: Sagar Bapat, M.D., Ph.D. and Ari B. Molofsky, M.D., Ph.D.