BMS Journal Club

September 13, 2018

Elliott Sherr, MD, PhD (Faculty)
"Uncrossed wires of crowns and pyramids"
Marsh, A.P. et al. Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance. Nature Genetics 49(4), 511-514. (2017).

Donovan Trinidad (Student)
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
Sibener, Leah V., et al. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell 174(3), 672-687. (2018)
Coaches: Joel Ernst and Jason Cyster

September 27, 2018

Martin Kampmann, PhD (Faculty)
"A wrinkle in time: RNA velocity of single cells"
La Manno, G. et al. RNA velocity of single cells. Nature 560, 494-498. (2018).

Naznin Jahan (Student)
"Epigenetic regulation of brain region-specific microglia clearance activity"
Ayata, P. et al. Epigenetic regulation of brain region-specific microglia clearance activity. Nature Neuroscience 21, 1049-1060. (2018).
Coaches: Eric Huang and Mercedes Paredes

October 11, 2018

Andy Chang, PhD (Faculty)
"Plants fight back with a nervous system-like pathway"
Toyota, M. et al. Glutamate triggers long-distance, calcium-based plant defense signaling. Science 361(6407), 1112-1115. (2018).

Catherine Tan (Student)
"Cancer nuclei should relax: Too much tension promotes DNA damage"
Xi, Y. et. Al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. Journal of Cell Biology, epub. (2018).
Coaches: Todd Nystul and Jay Debnath

October 25, 2018

David Solomon, MD, PhD (Faculty)
"Cohesin is awesome and also functions as a critical regulator of chromatin architecture"
Rao, S.S.P. et al. Cohesin loss eliminates all loop domains. Cell 171(2), 305-320. (2017).

Lindsey Pieper (Student)
"Resistance is Futile: A Gut Bacterium-Derived Metabolite Mediates  Colonization Resistance to Salmonella Infection"
Jacobson, A. et al. A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection. Cell Host Microbe 24, 296–307.e7. (2018).
Coaches: Joanne Engel and Peter Turnbaugh

November 8, 2018

Xianhua Piao, MD, PhD (Faculty)
"Nature vs Nurture: How Ontogeny and Environment Shape Microglial Identity"
Bennett, F.C. et al. A combination of ontogeny and CNS environment establishes microglial identity. Nueron 98(6), 1170-1183.e8. (2018).

Yuhao Wang (Student)
"Notch an Advantage for Cancer: How Notch3 and β-catenin regulate persistence in lung cancer cells"
Arasada, R.R. et al. Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC. Nature Communications 9(3198): 1-16.(2018).
Coaches: Michael McManus and Eric Collisson

November 29, 2018

Isha Jain, PhD (Faculty)
"Contracting Spleens and Evolutionary Adaptations to Deep Diving"
Ilardo, M.A. et al. Physiological and genetic adaptations to diving in sea nomads. Cell 173(3), 569-580. (2018).

Isobel Hawes (Student)
"Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement"
Lofano, G. et al. Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement. Science Immunology 3, eaat7796. (2018).
Coaches: Michael Wilson and Satish Pillai

January 10, 2019

Diane Barber, PhD (Faculty)
"Don’t suppress your CRAD"
Jung, Y.S. et al. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Nat Cell Biol 20(11):1303-1314. (2018).

David Shin (Student)
"Wanted, Dead or Alive: The Case of the Missing Subplate"
Ozair, M.Z. et al. hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate. Cell Stem Cell 23(1): 60-73.e6 (2018)
Coaches: Tomasz Nowakowski and Alex Pollen

January 24, 2019

Matthew Spitzer (Faculty)
“The mutants in us all”
Martincorena, et al. Somatic mutant clones colonize the human esophagus with age. Science (2018).

Nicholas Stevers (Student)
"Straight outta SVZ: Determining the anatomical and cellular origins of Glioblastoma."
Lee, J. H., et al. Human glioblastoma arises from subventricular zone cells with low-level driver mutations. Nature 560, 243-247 (2018).
Coaches: Joseph Costello and Joanna Phillips

February 7, 2019

Joel Ernst (Faculty)
"How does the Mosquito Microbiome Modulate Misery?"
Wu, Pa, et al. “A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses.” Cell Host & Microbe, 2018 Nov 28. pii: S1931-3128(18)30561-4. doi: 10.1016/j.chom.2018.11.004.

Fauna Yarza (Student)
"What a drag: Vibrio cholerae motility exerts drag force to impede attack by the bacterial predator Bdellovibrio bacteriovorus"
Duncan MC et al. Vibrio cholerae motility exerts drag force to impede attack by the bacterial predator Bdellovibrio bacteriovorus, Nature Communications 9:4757.
Coaches: Seemay Chou and Peter Turnbaugh

February 21, 2019

Jennifer Umhoefer (Student)
"Immune genes are primed for robutranscription by proximal long noncoding RNAs located in nuclear compartments"
Fanucchi, S. et al. Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments. Nature Genetics 51: 138-150 (2019).
Coaches: Abigail Buchwalter, Stephen Floor

Donovan Trinidad (Student)
"How Am I Supposed to Infect with No Air?: Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition"
Litvak, Litvak, Y., Mon, Nguyen, H., Chanthavixay, G., Liou, M., ... Bäumler, Y. (2019). Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition. Cell Host and Microbe, 25(1), 128-139.e5.
Coaches: Peter Turnbaugh, Suzanne Noble

March 7, 2019

Marissa Chou (Student)
"Eos inphil-tration: DPP4 inhibition enhances anti-tumor response"
Hollande, C. et al. Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth. Nature Immunology 20, 257–264 (2019).
Coaches: Jason Cyster and Ari Molofsky

Darwin Kwok (Student)
"Sizing Up Senescence: Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence"
Neurohr et al., 2019, Cell 176, 1083–1097 February 21, 2019 ª 2019 The Author(s). Published by Elsevier Inc.
Coaches: Fred Chang and Andrew Brack

March 21, 2019

Kyle Kisor (Student)
"Targeting Wnt/β-catenin pathway driven colorectal cancer via Bcl9/9l"
David Gay et al. Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications 10:723. (2019)
Coaches: Diane Barber and Todd Nystul

Jiapei Chen (Student)
"Deciphering the microglia transcriptome"
Li, Q. et al. Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing. Neuron 101, 207-223. (2019).
Coaches: Eric Huang and Tomasz Nowakowski

April 4, 2019

Abrar Choudhury (Student)
"The Devil is in the Details"
Kosack, L., Wingelhofer, B., Popa, A., Orlova, A., Agerer, B., Vilagos, B., Majek, P., Parapatics, K., Lercher, A., Ringler, A., et al. (2019). The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease. Cancer Cell 35, 125-139.
Coaches: David Raleigh and William Weiss

Marci Rosenberg (Student)
"Stay off the lawn! Herbicide enhances astrocyte pathogenicity via activation of the unfolded protein response"
Wheeler, Michael A. et al. (2019) Environmental control of astrocyte pathogenic activities in CNS inflammation. Cell 176, 581-596.. doi:    10.1016/j.cell.2018.12.012
Coaches: Anna Molofsky and Martin Kampmann

April 18, 2019

Daphne Superville (student)

“Neutrophils escort circulating tumour cells to enable cell cycle progression”
Szczerba BM, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, Scheidmann MC, Donato C, Scherrer R, Singer J, Beisel C, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Beerenwinkel N, Aceto N. Neutrophils escort circulating tumour cells to enable cell cycle progression. Nature. 2019 Feb;566(7745):553-557. doi: 10.1038/s41586-019-0915-y. Epub 2019 Feb 6. PubMed PMID: 30728496.
Coaches: Zena Werb and Melissa Reeves
 

Raymond Dai (student)
“Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics”
Ludwig, Leif S. et al. (2019). Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics. Cell 176, 1325-1339. doi: 10.1016/j.cell.2019.01.022
Coaches: Seth Shipman and Tomasz Nowakowski

May 2, 2019

Benjamin Wheeler (Student)
"Estradiol-ing in on HIV Latency: Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender sex-specific restrictions on the latent reservoir"
Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
Biswajit Das, Curtis Dobrowolski, Benjamin Luttge, Saba Valadkhan, Nicolas Chomont, Rowena Johnston, Peter Bacchetti, Rebecca Hoh, Monica Gandhi, Steven G. Deeks, Eileen Scully, Jonathan Karn
Proceedings of the National Academy of Sciences Aug 2018, 115 (33) E7795-E7804; DOI: 10.1073/pnas.1803468115
Coaches:Nadia Roan and Jason Cyster

Nick Mroz (Student)
"An Unexpected Source of IL-2: ILC3-derived Interleukin-2 Supports Intestinal Tregs and Gut Homeostasis"
Zhou, Lei et al. Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature (2019). doi: 10.1038/s41586-019-1082-x
Coaches: Ari Molofsky and Michael Rosenblum

May 16, 2019

Megan Montoya (Student)
"Genomic Instability causes Female-Biased Embryonic Death"
McNairn, AJ, Chuang, C, Bloom JC, Wallace MD, & Schimenti JC. (2019). Female-biased embryonic death from inflammation induced by genomic instability. Nature. 567: 105-108.
Coaches: Adrian Erlebacher and Scott Kogan

Brian Woo (Student)
"Lesser of two evils": Pol θ Error-Prone Replication Protects against Skin Cancers
Yoon, J. H., McArthur, M. J., Park, J., Basu, D., Wakamiya, M., Prakash, L., & Prakash, S. (2019). Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers. Cell, 176(6), 1295-1309.e1215. doi:10.1016/j.cell.2019.01.023
Coaches: Hani Goodarzi and Vijay Ramani
 

May 30, 2019

Bahar Zirak (Student)
"TAMs send their regards: HIF-1a stabilizing lncRNA from TAMs regulates aerobic glycolysis of breast cancer cells."
Chen, F. et al. Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Nature Cell Biology. 2019. doi: 10.1038/s41556-019-0299-0
Coaches: Hani Goodarzi and Isha Jain

Niko Eng (Student)
"Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods."
Sun F et al. "Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhood." Molecular Cell 2019, 73:250-263.  https://doi.org/10.1016/j.molcel.2018.10.039
Coaches: Yin Shen and Elphege Nora