BMS Journal Club

2022-23 Journal Club Schedule

Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location:In person at N-225 on the Parnassus campus, with a livestream/Zoom option as well. The Zoom link will be sent out with the email reminder sent to the BMS listservs. Please contact Demian Sainz if you are not already on one of our listservs.
Links to previous livestreams and recorded video are in the sidebar.


See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.


September 7, 2023

Peter Bruno (faculty)
"Vaccine-boosting improves CAR-T therapy and host immune response"
L. Ma, et al., Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity. Cell 186, 3148-3165.e20 (2023).

Isabelle Young (student)
"Scribble mis-localization induces adaptive resistance to KRASG12C inhibitors"
Adachi Y, Kimura R, Hirade K, et al. Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS. Nat Cancer. 2023;4(6):829-843. doi:10.1038/s43018-023-00575-2
Coaches: Jonathan Ostrem, MD, PhD & Michael Waterfield, MD, PhD


October 19, 2023

Michael Alexanian (faculty)
"New Frontiers in Epigenomics: Chromatin Remodeling in Alzheimer’s disease"
Xiong, James, Boix at al.,  Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion. 
Cell. 2023 Sep 28;186(20):4422-4437.e21. doi: 10.1016/j.cell.2023.08.040

Gary Chan (student)
"Gotta Target 'Em All: Reprogram myeloid cells in glioblastoma via KDM6B inhibition"
Goswami, S., Raychaudhuri, D., Singh, P. et al. Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade. Nat Cancer (2023). https://doi.org/10.1038/s43018-023-00620-0
Coaches: Joe Costello, PhD & Hideho Okada, MD, PhD


October 26, 2023

Rukman Thota (student)
"James Bonds favorite tumor model"
Chen, D. et al. CTLA-4 blockade induces CD4+ T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma. Immunity 56, 2086-2104.e8 (2023).
Coaches: Alexis Combes, PhD & Andrew Yang, PhD


November 9, 2023

Elphege Nora (faculty)
"Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus"
Gjaltema et al., Molecular Cell https://www.sciencedirect.com/science/article/pii/S109727652101025X?via%3Dihub

Jing-Yi Chung (student)
"A new macrophage polarity called “CS” "
Bill, R. et al., CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science 381,515-524(2023). DOI:10.1126/science.ade2292
Coaches: Matt Spitzer, PhD & Roarke Kamber, PhD


November 16, 2023

Khang Nguyen (student)
"The Last of the TME (TumorMycoEnvironment)" 
Liu, Ning-Ning et al. “The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells.” Cancer cell, S1535-6108(23)00288-X. 19 Sep. 2023, doi:10.1016/j.ccell.2023.08.012
Coaches: Jeroen Roose, PhD & Mary Helen Barcellos-Hoff, PhD


December 7, 2023

Jayden Ross (student)
"CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice"
Sun, S., Meng, Y., Li, M. et al. CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice. Nat Aging 3, 1401–1414 (2023). https://doi.org/10.1038/s43587-023-00512-z
Coaches: Betsy Crouch, MD, PhD & Ethan Winkler, MD, PhD


December 14, 2023

David Raleigh (faculty)
"Two wrongs apparently make one wrong a little less wrong."
Ling, A.L., Solomon, I.H., Landivar, A.M. et al. Clinical trial links oncolytic immunoactivation to survival in glioblastoma. Nature 623, 157–166 (2023). https://doi.org/10.1038/s41586-023-06623-2

Max Pass (student)
“The one that didn’t get away: a distinct intratumoral population of cDC1s that amplify CD8 T cell responses"
Meiser, P. et al. A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity. Cancer Cell 0, (2023).
Coaches: Matt Spitzer, PhD & Max Krummel, PhD


January 11, 2024

Maddie Urbanek (student)
"Getting Groovy with Epi-Retro-seq"
Zhou, J., Zhang, Z., Wu, M. et al. Brain-wide correspondence of neuronal epigenomics and distant projections. Nature 624, 355–365 (2023). https://doi.org/10.1038/s41586-023-06823-w
Coaches: Betsy Crouch, MD, PhD & Cathryn Cadwell, MD, PhD

Sara Misiukiewicz (student)
"UndersTANding TANs: The local microenvironment drives activation of neutrophils in human brain tumors."
Maas RR, et al. The local microenvironment drives activation of neutrophils in human brain tumors. Cell. 2023 Oct 12;186(21):4546-4566.e27. doi: 10.1016/j.cell.2023.08.043. Epub 2023 Sep 27. PMID: 37769657.
Coaches: Roarke Kamber, PhD & Matt Spitzer, PhD


January 18, 2024

Julia McBride (student)
"An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis"
LaMarche, N.M., Hegde, S., Park, M.D., Maier, B.B., Troncoso, L., Le Berichel, J., Hamon, P., Belabed, M., Mattiuz, R., Hennequin, C., et al. (2023). An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature, 1–9. 10.1038/s41586-023-06797-9.
Coaches: Alejandro Sweet-Cordero, MD & TBD

Celeste Garza (student)
"Sensory neurons promote immune homeostasis in the lung"
Masato Tamari et al. Sensory neurons promote immune homeostasis in the lung. Cell. 2024, Pages 44-61.e17, SSN 0092-8674, https://doi.org/10.1016/j.cell.2023.11.027.
Coaches: Roberto Ricardo-Gonzalez, MD, PhD & Marlys Fassett, MD, PhD


January 25, 2024

Madeline McCanne (student)
"Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing"
Mishra, A. K. et al. Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing. Proceedings of the National Academy of Sciences 120, e2310221120 (2023).
Coaches: Jason Cyster, PhD & Max Krummel, PhD

Sangeetha Ramachandran (student)
"Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer"
Ayuso, J.M., Farooqui, M., Virumbrales-Muñoz, M. et al. Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer. Nat Commun 14, 6681 (2023). https://doi.org/10.1038/s41467-023-41625-8
Coaches: Oscar Aguilar, PhD & Catera Wilder, PhD


February 15, 2024

Sarah Castro (student)
“Save room for de(ssert) mushrooms: how fungi trigger an anti-tumor response”
Max M. Wattenberg et al. Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1.Sci. Immunol.8,eadj5097(2023).DOI:10.1126/sciimmunol.adj5097
Coaches: Oliva Lu, PhD & Karin Pelka, PhD

Ivan Chavez (student)
"Damsels in Drag: The evolutionary genomics of intersexual mimicry in damselflies"
Willink, B., Tunström, K., Nilén, S. et al. The genomics and evolution of inter-sexual mimicry and female-limited polymorphisms in damselflies. Nat Ecol Evol 8, 83–97 (2024). https://doi.org/10.1038/s41559-023-02243-1
Coaches: David Booth, PhD & TBD


February 22, 2024

Minna Apostolova (student)
"The (T cell) Mandela Effect: Flexibility in T cell Memory Formation"
Abadie, Kathleen et al. “Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision.” Immunity, S1074-7613(23)00537-X. 29 Jan. 2024, doi:10.1016/j.immuni.2023.12.006
Coaches: Matt Spitzer, PhD & Rachel Rutishauser, MD, PhD

Manon Miller (student)
"Interferon-ε is a tumor suppressor and restricts ovarian cancer"
Marks, Z.R.C., Campbell, N.K., Mangan, N.E. et al. Interferon-ε is a tumour suppressor and restricts ovarian cancer. Nature 620, 1063–1070 (2023). https://doi.org/10.1038/s41586-023-06421-w
Coaches: Katherine Fuh, MD, PhD & Alexis Combes, PhD


March 7, 2024

Ankit Salhotra (student)
TBD
Badr, M. E., Zhang, Z., Tai, X., & Singer, A. (2023). CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus. Science, 382(6670), 534–541. https://doi.org/10.1126/science.adh4124
Coaches: Peter Bruno, PhD & Mark Anderson, MD, PhD

Claire Havig (student)
TBD
Coaches: Tiffany Scharschmidt, MD & Julia Carnevale, MD


March 14, 2024

Rachel Prorok (student)
TBD

Nikhita Kirthivasan (student)
TBD
Coaches: Jason Cyster, PhD and Clifford Lowell, MD, PhD


March 21, 2024

Vickie Bowcut (student)
TBD

Serena Lu (student)
TBD
Coaches: Dan Lim, MD, PhD & Abby Buchwalter, PhD


March 28, 2024

Riana Hunter (student)
TBD

Mingyang Ma (student)
TBD
Coaches: Maggie Feeney, MD & Mary Prahl, MD


April 4, 2024

Andrew Pan (student)
TBD

Courtney Tamaki (student)
TBD


April 11, 2024

Lily Zemelko (student)
TBD

Tasha Tsao (student)
TBD


April 18, 2024

Jose Gomez (student)
TBD

Kira Downey (student)
TBD


April 25, 2024

Charles Shen (student)
TBD

Trishna Patel (student)
TBD


May 2, 2024

Karla DeLucas (student)
TBD

Rebecca Chu (student)
TBD


May 9, 2024

Harnoor Virk (student)
TBD

Mackenzie Roberts (student)
TBD


May 16, 2024

Lauren Tabor (student)
TBD

Joy Okoro (student)
TBD


May 23, 2024

Cassie Martinez (student)
TBD

Zachary Holmes (student)
TBD