BMS Journal Club

2022-23 Journal Club Schedule

Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location:In person at N-225 on the Parnassus campus, with a livestream/Zoom option as well. The Zoom link will be sent out with the email reminder sent to the BMS listservs. Please contact Demian Sainz if you are not already on one of our listservs.
Links to previous livestreams and recorded video are in the sidebar.

See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.

September 8, 2022

*Introduction to Journal Club with Journal Club co-Chairs Bruce Wang and Tien Peng*

Meagan Olive (student)
"The right to choose: Gamma delta T cells take up residence in the decidua for a novel role in early pregnancy"
Yang, S., et al. Early pregnancy human decidua gamma/delta T cells exhibit tissue resident and specific functional characteristics. Mol Hum Reprod. 2022 Jul 29;28(8):gaac023. doi: 10.1093/molehr/gaac023. PMID: 35758607.
Coaches: Tiffany Scharschmidt, MD & David Raleigh, MD, PhD

September 29, 2022

Cathryn Cadwell, MD, PhD (faculty)
"Brain cell type atlases: The key to understanding neurobiology, or aimless stamp collecting?"
Berg, J., Sorensen, S.A., Ting, J.T. et al. Human neocortical expansion involves glutamatergic neuron diversification. Nature 598, 151–158 (2021).

Charlotte Wang (student)
"All types of screens: unmasking cancer"
Kishton, R. J., et al. (2022). Cancer genes disfavoring T cell immunity identified via integrated systems approach. Cell reports, 40(5), 111153.
Coaches: Julia Carnevale, MD & David Nguyen, MD, PhD


October 13, 2022

Franklin Huang, MD, PhD (faculty)
"Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors"Nassar, A.H., Adib, E., Abou Alaiwi, S. et al. Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors, Cancer Cell,2022, ISSN 1535-6108,\

Rita Loudermilk (student)
"Shining a Light on Cell-Cell Interactions"
Oslund, R.C., Reyes-Robles, T., White, C.H. et al. Detection of cell–cell interactions via photocatalytic cell tagging. Nat Chem Biol 18, 850–858 (2022).
Coaches: Alexis Combes, PhD & Gabi Fragiadakis, PhD

October 20, 2022

Xin Duan, PhD (faculty)
"May the force be with your neurons at the right moment"
Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures in a Mouse Model of Arthrogryposis
Shang Ma, et al,  Ardem Patapoutian (Biorxiv, 2022)

Evan Semenza (student)
"This is your brain on (fatty) acid: metabolic involvement in the evolutionary expansion of the cerebral cortex"
Pinson, A., et al. (2022) Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. Science 377(6611).
Coaches: Corey Harwell, PhD & Daniel Lim, MD, PhD

November 3, 2022

Timothy Henrich, MD (faculty)

Caroline Whitty (student)
"I'll have the de-CAF"
Krishnamurty, A.T., Shyer, J.A., Thai, M. et al. LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature (2022).

Coaches: Dean Sheppard, MD & Eric Collisson, MD

January 26, 2023

Sophia Nelson (student)
"Fancy MAIT-ing you here: uncovering a new role for MAIT cells in meningeal homeostasis and cognitive function"
Zhang, Y., Bailey, J.T., Xu, E. et al. Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function. Nat Immunol 23, 1714–1725 (2022).
Coaches: Ari Molofsky, MD, PhD & Andrew Yang, PhD 

February 23, 2023

Jingwen Ding (student)
"DNA repair induces aging through epigenetic alterations"
Yang, Jae-Hyun et al. “Loss of epigenetic information as a cause of mammalian aging.” Cell vol. 186,2 (2023): 305-326.e27. doi:10.1016/j.cell.2022.12.027
Coaches: Abby Buchwalter, PhD & Saul Villeda, PhD

Maddie Urbanek (student)
"Dancing through development: TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages"
Espinosa-Medina I, Feliciano D, Belmonte-Mateos C, Linda Miyares R, Garcia-Marques J, Foster B, Lindo S, Pujades C, Koyama M, Lee T. TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages. Neuron. 2022 Nov 18:S0896-6273(22)00995-3. doi: 10.1016/j.neuron.2022.10.035. Epub ahead of print. PMID: 36417906.
Coaches: Ryan Corces, PhD & Mercedes Paredes, MD, PhD

March 9, 2023

Kai Trepka (student)
"I've got your bac: E. coli degradation of a toxic drug rescues growth of Fusobacterium and cancer cells"
LaCourse, Kaitlyn et al. "The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota." Cell Reporters vol. 41,7 (2022):111625. doi: 10.1016/j.celrep.2022.111625.
Coaches: Rohit Bose, MD, PhD & Peter Turnbaugh, PhD

Minna Apostolova (student)
“Working 9 to CD5: dendritic cells expressing CD5 improve response to immune checkpoint blockade therapy in cancer”
He, Mingyu et al. “CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses.” Science (New York, N.Y.) vol. 379,6633 (2023): eabg2752. doi:10.1126/science.abg2752. 
Coaches: Matt Spitzer, PhD & Kole Roybal, PhD

March 23, 2023

Kadellyn Sandoval Gutierrez (student)
"We don't fit in our genes: Epigenetic mechanism behind transgenerational BPA-induced obesity"
Yoon Hee Jung et al. Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity. PNAS. 119(50). 2022.
Coaches: Mercedes Paredes, MD, PhD & Tomasz Nowakowski, PhD

Amy Chen (student)
“CLASH” of the T cells: A Cas12a screening approach identifies PRDM1 Δexon3 as a regulator of CAR T exhaustion"
Dai, X., Park, J.J., Du, Y. et al. Massively parallel knock-in engineering of human T cells. Nat Biotechnol (2023).
Coaches: Sagar Bapat, MD, PhD & Arun Wiita, MD, PhD

March 30, 2023

Julianne Riggs (student)
"Tale of the Ten-Year Experiment"
Soerens, A.G., Künzli, M., Quarnstrom, C.F. et al. Functional T cells are capable of supernumerary cell division and longevity. Nature (2023).
Coaches: Tiffany Scharschmidt, MD & Qizhi Tang, PhD

Li Wang (student)
"Don’t leave me on read—regulation of antitumor immunity by m6A reader in macrophage"
Ma, S., Sun, B., Duan, S. et al. YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells. Nat Immunol 24, 255–266 (2023).
Coaches: Robert Blelloch, MD, PhD & Caroline Vissers, PhD

April 6, 2023

Amrik Kang (student)
Coaches: Arun Wiita, MD, PhD & Justin Eyquem, PhD

Riana Hunter (student)
"Liver stage malaria... with some fava beans and a nice chianti: Interplay between liver stage and blood stage of Plasmodium infection dictate malaria severity"
Ângelo Ferreira Chora, et al. "Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis". Immunity (2023):
Coaches: Margaret Feeney, MD & Rachel Rutishauser, MD, PhD

April 27, 2023

Mingyang Ma (student)
Hsueh, B., Chen, R., Jo, Y. et al. Cardiogenic control of affective behavioural state. Nature 615, 292–299 (2023).
Coaches: Ritchie Chen, PhD, MSc, BS & Guo Huang, PhD

Jaela Caston (student)

May 4, 2023

Sara Misiukiewicz (student)

Zachary Stensland (student)

May 11, 2023

Isabel Shen (student)

Manon Miller (student)

May 18, 2023

Rukman Thota (student)

Gabriella Kimmerly (student)

May 25, 2023

Sarah Castro (student)

Anita Qualls (student)

June 1, 2023

Jun Hyung Sin (student)

Victoria Bowcut (student)