BMS Journal Club 2016-17

BMS Journal Club presentations are available via livestream and recorded video. You can access them via the links below. UCSF MyAccess login is required.

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September 8, 2016

Aaron Diaz, PhD (faculty)
"Clonal evolution of glioblastoma under therapy"
Wang, J. "Clonal evolution of glioblastoma under therapy." Nature. 2016 Jul; 48(7): 768-76.

Daniel Wong (student)
"Wnt maturity calls, you beta get to work"
Bader E et al. "Identification of proliferative and mature β-cells in the islets of Langerhans."Nature. 2016 Jul 21;535(7612):430-4.
Coaches: Julie Sneddon and Anil Bhushan 

Room N-225 at Parnassus, with Mission Bay videoconference in MH-1405

September 15, 2016

Daniel Bunis (student)
"CARs for HIV: an old road that may lead to a new cure"
Ali A, Kitchen SG, Chen IS, Ng HL, Zack JA, Yang OO. "HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies." Journal of Virology. 2016 Jul 11;90(15):6999-7006.
Coaches: Jay Levy and Trevor Burt

Eric Collisson (faculty)
"High-throughput Phenotyping of Lung Cancer Somatic Mutations"
Berger, A.H., "High-throughput Phenotyping of Lung Cancer Somatic Mutations." Cancer Cell. 2016 Aug 8;30(2): 214-28.

Mission Bay videoconference: MH-1407 (updated)

September 22, 2016

Sarah McMahon (student)
"Bye,bye,bye bad rhythm, we're getting IN Sync" 
Nadadur RD et al. "Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm." Sci. Transl. Med. 2016 Aug 31; 35(17):2892-909.
Coaches: Saptarsi Haldar and Benoit Bruneau

Sophie Dumont (faculty)
"Road signs on microtubules guide chromosomes during mitosis."
Barisic, M. "Microtubule detyrosination guides chromosomes during mitosis."  Science. 2015 May 15;348(6236):799-803.

Mission Bay videoconference: MH-1405

September 29, 2016

Carlos Castellanos (student)
"un-TAM-ing the type 2 immune response"
Chan, P.Y., et al. "The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity." Science. 2016. Apr 1; 352(6281) 99-103.
Coaches: Ari Molofsky and Jeoung-Sook Shin

JJ Miranda (faculty)
"BETting on cancer therepeutic resistance"
Rathert P., et al. "Transcriptional plasticity promotes primary and acquired resistance to BET inhibition." Nature. 2015. Sep 24; 525(7570): 543-7.

Mission Bay videoconference: MH-1405

October 6, 2016

Jessica Cortez (student)
"Finding Memory: The Quest of the Forgetful Treg"
Van der Veeken, J et al. "Memory of Inflammation in Regulatory T cells." Cell. 2016 Aug 11; 166(4): 977-90.
Coaches: Michael Rosenblum and Alexander Marson 

Tien Peng (faculty)
"Why is nothing happening? Maintenance of stem cell quiescence in adult organs"
Balasooriya, GI et al. "An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium." Dev Cell. 2016 Apr 4; 37(1): 85-97.

Mission Bay videoconference: MH-1405

October 13, 2016

Emily Davis (student)
"Astrocytic mitochondria are the powerhouse of neuronal cells (after stroke)"
Hayakawa, K., et al. "Transfer of mitochondria from astrocytes to neurons after stroke." Nature. 2016. Jul 28; 535: 551-555.
Coaches: Dena Dubal and Anna Molofsky

Biao Wang (faculty)
"Mitochondrial stress: friend or foe"
Berendzen KM, et al. "Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis." Cell. 2016. Sep 8; 166(6): 1553-1563.

Mission Bay videoconference: MH-1405

October 20, 2016

Andrea Eastes (student)
"The Mitobolome: A Snapshot of a Dynamic Powerhouse"
Chen, W et al. “Absolute Quantification of Matrix Metabolites Reveals the Dynamic of Mitochondrial Metabolism.” Cell. 2016 Aug 25; 166(5): 1324:1337.
Coaches: Rushika Perera and Jay Debnath

Ken Nakamura (faculty)
"Oxygen deprivation – a promising therapy for insufficient respiration ??"
Jain, IH et al. "Hypoxia as a therapy for mitochondrial disease." Science. 2016. Apr 1; 352(6281): 54-61.

Mission Bay videoconference: MH-1405

October 27, 2016

Kimberly Hoi (student)
"The Choroid Plexus: a window into brain aging"
Silva-Vargas V, et al.  "Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells." Cell Stem Cell. 2016. Jul 19. pii: S1934-5909(16)30163-1.
Coaches: Arturo Alvarez-Buylla and Saul Villeda

Allison Xu (faculty)
"A ketone drink before your next marathon?"
Cox, P. et al. "Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes." Cell Metabolism. 2016. Aug 9; 24(2): 256-68.

Mission Bay videoconference: MH-1405

November 3, 2016

Alana Horowitz (student)
"I’m with Hangry: Tyrosine Hydroxylase Neurons make Feeding Great Again!"
Zhang, X and A.N. van den Pol. "Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis." Nature Neuroscience. 2016. 19(10): 1341-7.
Coaches: Saul Villeda and Allison Xu

Raymond Swanson (faculty)
"A portal promoting prion-like propagation of Parkinson pathology"
Mao, X et al. "Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3." Science. 2016 Sep 30; 353(6307).

Mission Bay videoconference: MH-1405

November 10, 2016

Rebecca Jaszczak (student)
"What’s in a dish? A mouse made by in vitro means still squeaks"
Hikabe, O. et al. "Reconstitution in vitro of the entire cycle of the mouse female germ line." Nature. 2016. Oct 17. doi: 10.1038/nature20104. [Epub ahead of print]
Coaches: Marco Conti and Miguel Ramalho-Santos

Mary Helen Barcellos-Hoff (faculty)
"RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers"
Nolen, E et al. "RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers." Nature Medicine. 2016. 22:933-939.

Mission Bay videoconference: MH-1405

November 17, 2016

Simone Kurial (student)
"Of Mice and Snakes: Progressive Loss of Function in a Limb Enhancer during Snake Evolution"
Kvon, Evgeny Z. et al. "Progressive Loss of Function in a Limb Enhancer during Snake Evolution." Cell. 2016. 167 (3):633-642. 
Coaches: Holger Willenbring and Alex Marson

Jennifer Grandis (faculty)
"Mechanisms of Resistance to Tyrosine Kinase Inhibitors" with Dr. Dan Johnson
Miller, M et al. "Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance." Cancer Discover. 2016. 6(4): 382-99.

Mission Bay videoconference: MH-1405

December 1, 2016

Phi Nguyen (student)
"Total Recall: a shared neural ensemble links distinct contextual memories encoded close in time"
Cai, D. J. et al. "A shared neural ensemble links distinct contextual memories encoded close in time." Nature. 2016. 534: 115–118.
Coaches: Mazen Kheirbek and Loren Frank

David Solomon (faculty)
"Cohesin inactivation is a novel mechanism of resistance to targeted therapy in cancer"
Shen, C.H. et al. "Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma." Nature Medicine. 2016, 22(9): 1056-61.

Mission Bay videoconference: MH-1405

December 8, 2016

Tonatiuh Montoya (student)
"Unusual processing of snoRNAs and lncRNAs: it' sno joke"
Wu, H. et al. "Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins." Molecular Cell. 2016. 64(3): 534-548.
Coaches: Mary McMahon and Davide Ruggero 

Trever Bivona (faculty)
"SHPing cancer out"
Ying-Nan, P. et al. "Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases." Nature. 2016. 535:148-152.

Mission Bay videoconference: MH-1405

January 12, 2017

Walter Mancia (student)
"Fear Erasure Facilitated by Immature Inhibitory Neuron Transplantation"
Yang, W.Z., et al. "Fear Erasure Facilitated by Immature Inhibitory Neuron Transplantation." Neuron. Nov 25 pii: S0896-62. 
Coaches: Arturo Alvarez-Buylla and Georgia Panagiotakos 

Mark Ansel (faculty)
"Aeroallergens slip through the cracks of dominant tolerance"
Bacher P, et al. "Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans."  Cell. 2016 Nov 3; 167(4): 1067-1078.

Mission Bay videoconference: MH-1405

January 19, 2017

Andrew McKinney (student)
"A Variant on Copy Number Analyses: Cis-Regulatory Elements Instead of Gene Dosage"
Weischenfeldt J., et al. "Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking." Nature Genetics. 2017. 49: 65-74.
Coaches: Eric Collisson and Joseph Costello

Jay Debnath (faculty)
"KRAS and stress granules in cancer"
Grabocka, E. and D. Bar-Sagi. "Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules." Cell. 2016. 167(7):1803-1813.

Mission Bay videoconference: MH-1405

January 26, 2017

Andrew McNeal (student)
"A Hairy Situation: Regeneration of fat cells from myofibroblasts during wound healing"
Plikus, M. et al. "Regeneration of fat cells from myofibroblasts during wound healing." Science. 2017. Jan (DOI: 10.1126/science.aai8792).
Coaches: Rob Judson and Shingo Kajimura

Robert Blelloch (faculty)
"In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming"
Ocampo, A., et al. "In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming". Cell. 2016. 167(7):1719-1733.

Mission Bay videoconference: MH-1405

February 2, 2017

Tina Solvik (student)
"Putting a Damper on the FUNgi: DAPK1 and LAP"
Oikonomou V.,  et al. “Noncanonical fungal autophagy inhibits inflammation in response to IFN-γ via DAPK1.” Cell Host Microbe. 2016. 20: 744-757.
Coaches: Jay Debnath and Anita Sil

Joe Hiatt (student)
"How old are viruses?"
Aiewsakun P. and A. Katzourakis. "Marine origin of retroviruses in the early Palaeozoic Era." Nature Communications. 2017. doi:10.1038/ncomms13954
Coaches: Alex Marson and Joseph Bondy-Denomy

Mission Bay videoconference: MH-1405

February 9, 2017

Casey Beppler (student)
"Lymphocytes go home after dark: T and B Cell Circadian Clocks Control Trafficking"
Druzd, D., et al. "Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses." Immunity. 2017. 46(1): 120-132.
Coaches: Jason Cyster and Ying-Hui Fu

Mark Anderson (faculty)
"Display of chimeric “self” by the immune system"
Liepe, J., et al. "A large fraction of HLA Class I ligands are proteasome-generated spliced peptides." Science. 2016. 354(6310): 354-358.

Mission Bay videoconference: MH-1405

February 16, 2017

Ariane Panzer (student)
"Alternative Facts: Does Delivery Mode Influence Bacterial Attendance at the Inauguration of the Infant Microbiome?"
Chu, D.M., et al. “Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery.” Nature Medicine. 2017 Jan 23. doi: 10.1038/nm.4272. [Epub ahead of print].
Coaches: Susan Lynch and Peter Turnbaugh

Robert Raffai (faculty)
"High on Sugar, HSCs you Break my Heart"
Sarrazy, V., et al. "Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques of ApoE(-/-) Mice." Circulation Research. 2016. 118(7): 1062-77.

Mission Bay videoconference: MH-1405

February 23, 2017

Mark-Phillip Pebworth (student)
"Ask not for whom the brain folds: Gyrification in Cerebral Organoids"
Li, Y., et al. "Induction of Expansion and Folding in Human Cerebral Organoids." Cell Stem Cell. 2017. 20:1-12.
Coaches: Arnold Kriegstein and Arturo Alvarez-Buylla 

Andy Chang (faculty)
"Sensing the urge to breathe"
Kumar, N.N., et al. "Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons." Science. 2015. 348(6240): 1255-60.

Mission Bay videoconference: MH-1405

March 2, 2017

Germaine Yong (student)
"May The Gut Microbes Be With You - Harnessing Your Gut Microbial Metacommunity To Maximize Nutritional Therapy"
Griffin, N., et al. "Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions." Cell Host & Microbe. 2017. 21(1): 84-96.
Coaches: Peter Turnbaugh and Suneil Koliwad

Licia Selleri (faculty)
"Human Organs from Beastly Animal Bodies"
Wu, J. et al. "Interspecies Chimerism with Mammalian Pluripotent Stem Cells." Cell. 2017. 168 (3): 473-486.

Mission Bay videoconference: MH-1405

March 9, 2017

Theodore Roth (student)
"Listen to your mother- chewing drives homeostatic oral immune responses"
Dutzan, N., et al. "On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier." Immunity. 2017. 46(1): 133-147.
Coaches: Alex Marson and Mark Anderson

Mission Bay videoconference: MH-1405

March 16, 2017

Breanna Allen (student)
"The Yin and Yang of Neuroimmune Response"
Liddelow, S.A., et al. "Neurotoxic reactive astrocytes are induced by activated microglia." Nature. 2017. 541: 481-487.
Coaches: Anna Molofsky and Matthew Spitzer

Patrick Schupp (student)
"Phage News: A New Paradigm in Inter-phage Communication during Infection"
Erez, Z., et al. Communication between viruses guides lysis–lysogeny decisions. Nature. 2017. 541: 488–493.
Coaches: Joseph Bondy-Denomy and Shaeri Mukherjee 

Mission Bay videoconference: MH-1405

March 23, 2017

Jerika Barron (student)
"The original 3D cell culture: Using a humanized mouse brain to model Alzheimer’s"
Espuny-Camacho, I., et al. "Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain." Neuron. 2017. 93(5): 1066-1081.
Coaches: Eric Huang and Jen Yokoyama

Camile Simoneau (student)
"The true drought culprit: CD8+ T cells decrease reservoir size"
Takata, H., et al. "Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection." Science Translational Medicine. 2017. 9:(377).
Coaches: Melanie Ott and Trevor Burt

Mission Bay videoconference: MH-1405

March 30, 2017

Parinaz Fozouni (student)
"The elusive HIV reservoir: finding the latent needle in the haystack"
Descours, B., et al. “CD32a is a marker of a CD4 T-cell HIV reservoir harboring replication-competent proviruses.” Nature. 2017 Mar 15; doi:10.1038/nature21710.
Coaches: Melanie Ott and Maggie Feeney

Sara Sunshine (student)
"Past vs. Present: What Made the 2013-2016 Ebola Epidemic Different?"
Diehl, W. E., et al. "Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic." Cell. 2016. 167: 1088–1098.e6.
Coaches: Shaeri Mukherjee and Melanie Ott

Mission Bay videoconference: MH-1405

April 6, 2017

Elma Frias (student)
"When life gives you iPSCs, make microglia."
Pandya, H., et al. 2017. “Differentiation of Human and Murine Induced Pluripotent Stem Cells to Microglia-like Cells.” Nature Neuroscience. 2017. doi:10.1038/nn.4534. [Epub ahead of print]
Coaches: Susanna Rosi and Eric Huang

David Wu (student)
"Hey, keep your mom and dad jeans on! (Indecent) exposure of young neurons to recessive alleles."
Huang, W., et al. "Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain." Neuron. 2017. 93(5): 1094-1109.
Coaches: Daniel Lim and Alex Pollen

Mission Bay videoconference: MH-1405

April 13, 2017

Anthony Venida (student)
"HIIT the gym! Your gene transcripts, ribosomal proteins, and mitochondrial gains will thank you later."
Robinson, M.M., et al. Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans. Cell Metabolism. 2017. 25(3), 581–592.
Coaches: Rushika Perera and Shingo Kajimura

Nicholas Gentry (student)
"A not-so-Summery tale: a Fall in molecular rhythmic consistency may Spring upon us in the Winter of our lives"
Lim, A.S.P., et al. "Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease." Nature Communications. 2017. 8(149310" 1-16.
Coaches: Louis Ptacek and Miguel Ramalho-Santos

Mission Bay videoconference: MH-1405

April 20, 2017

Jeanmarie Gonzalez (student)
"Flavivirus Family Feud: Prior exposure to Dengue enhances Zika infection"
Bardina, S.V., et al. "Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity." Science. 2017. Mar 30. pii: eaal4365.
Coaches: Shomyseh Sanjabi and Tiffany Scharschmidt

Elise Wolf (student)
"A double edged sword: PI3K inhibitors provide AID to lymphoma"
Compagno, M., et al. "“Phosphatidylinositol 3-Kinase δ Blockade Increases Genomic Instability in B Cells.” Nature. 2017. 542 (7642): 489–93.
Coaches: Jason Cyster and Ari Molofsky

Mission Bay videoconference: MH-1405

April 27, 2017

Kamir Hiam (student)
"Optimize Prime: T Cell Mediated Superclusters Transform Immunity"
Brewitz, A., et al.  "CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.” Immunity. 2017. 46(2): 205–219.
Coaches: Matthew Spitzer and Jeong-Sook Shin

Jeremy Williams (student)
"Lending piece of mind: The pro-metastatic transfer of cGAMP from brain metastases to astrocytes"
Chen, Q., et al. "Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer." Nature. 2016. 533(7604), 493–498.
Coaches: Rushika Perera and Andrei Goga

Mission Bay videoconference: MH-1405

May 4, 2017

Karen Wong (student)
"Embodying Diversity: Friend or Foe?"
Morrissy, A., et al. "Spatial heterogeneity in medulloblastoma." Nature Genetics. 2017. 49: 780-788.. 
Coaches: Joe Costello and Pui Kwok


Mission Bay videoconference: MH-1405

May 11, 2017

Austin Hsu (student)
"Beats by Macrophage"
Hulsmans, M., et al. "Macrophages Facilitate Electrical Conduction in the Heart.” Cell. 2017. 169(3): 510-522.e520.
Coaches: Rahul Deo and Guo Huang

Erron Titus (student)
"Mess with your soul like ether: Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG"
Wang, W. and R. MacKinnon. "Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG." Cell. 2017. 169(3): 422-430.
Coaches: Rahul Deo and Michael Grabe

Mission Bay videoconference: MH-1405

May 18, 2017

Johnny Yu (student)
"DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome"
Aktas, T., et al. "DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome." Nature. 2017. 544: 115-119.
Coaches: Hani Goodarzi and Bassem Al-Sady

Alexis Krup (student)
"Flight of the interneurons: Recapitulating saltatory migration in forebrain spheroids"
Birey, F., et al. "Assembly of functionally integrated human forebrain spheroids." Nature. 2017. 545: 54-59.
Coaches: Michael Oldham and Julie Sneddon

Mission Bay videoconference: MH-1405

May 25, 2017

Geil Merana (student)
"All Downhill From Here: How Age-Associated Changes in the Microbiome Promote Immune Dysfunction"
Thevaranjan, N., et al. "Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction." Cell Host & Microbe. 2017. 21(4): 455–466.
Coaches: Susan Lynch and Tiffany Scharschmidt

Katherine Yu (student)
"Breaking it down: Finding the building blocks that regulate mRNA stability"
Yartseva, V. et al. "RESA identifies mRNA-regulatory sequences at high resolution." Nature Methods. 2017. 14(2): 201-207.
Coaches: Hani Goodarzi and David Erle 

Mission Bay videoconference: MH-1405

June 1, 2017

Ramiro Patino (student)
"To be, or not to be curved, that is the question of Vibrio cholerae"
Bartlett, T. M., et al. "A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis." Cell. 2017.  168: 172–185.e15.
Coaches: Shaeri Mukherjee and Joanne Engel 

Nikolai Zapero (student)
Consuming Youthful Ordure Each Day Keeps The Doctor Away: Life Span Regulation Through Gut Microbiota in the African Turquoise Killifish
Smith, P., et al. "Regulation of Life Span by the Gut Microbiota in The Short-Lived African Turquoise Killifish." bioRxiv. 2017.
Coaches: Saul Villeda and Peter Turnbaugh

Mission Bay videoconference: MH-1405

June 8, 2017

Wandi (Didi) Zhu (student)
"BAFFling Association with Autoimmunity Disorders"
Steri, M., et al. "Overexpression of the Cytokine BAFF and Autoimmunity Risk." 2017. N Engl J Med 376: 1615-1626.
Coaches: Mark Ansel and Marina Sirota

Katerina Popova (student)
"Can we just say translational control second? Dynamic control of protein synthesis during erythropoiesis"
Alvarez-Dominguez, J.R., X. Zhang, and W. Hu. "Widespread and dynamic translational control of red blood cell development." 2017. Blood 129(5): 619-629.
Coaches: Martin Kampmann and Hani Goodarzi

Mission Bay videoconference: MH-1405