BMS Journal Club presentations are available via livestream and recorded video. You can access them via the links below. UCSF MyAccess login is required.
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September 8, 2016
Aaron Diaz, PhD (faculty)
"Clonal evolution of glioblastoma under therapy"
Wang, J. et.al. "Clonal evolution of glioblastoma under therapy." Nature. 2016 Jul; 48(7): 768-76.
Daniel Wong (student)
"Wnt maturity calls, you beta get to work"
Bader E et al. "Identification of proliferative and mature β-cells in the islets of Langerhans."Nature. 2016 Jul 21;535(7612):430-4.
Coaches: Julie Sneddon and Anil Bhushan
Room N-225 at Parnassus, with Mission Bay videoconference in MH-1405
September 15, 2016
Daniel Bunis (student)
"CARs for HIV: an old road that may lead to a new cure"
Ali A, Kitchen SG, Chen IS, Ng HL, Zack JA, Yang OO. "HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies." Journal of Virology. 2016 Jul 11;90(15):6999-7006.
Coaches: Jay Levy and Trevor Burt
Eric Collisson (faculty)
"High-throughput Phenotyping of Lung Cancer Somatic Mutations"
Berger, A.H., et.al. "High-throughput Phenotyping of Lung Cancer Somatic Mutations." Cancer Cell. 2016 Aug 8;30(2): 214-28.
Mission Bay videoconference: MH-1407 (updated)
September 22, 2016
Sarah McMahon (student)
"Bye,bye,bye bad rhythm, we're getting IN Sync"
Nadadur RD et al. "Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm." Sci. Transl. Med. 2016 Aug 31; 35(17):2892-909.
Coaches: Saptarsi Haldar and Benoit Bruneau
Sophie Dumont (faculty)
"Road signs on microtubules guide chromosomes during mitosis."
Barisic, M. et.al. "Microtubule detyrosination guides chromosomes during mitosis." Science. 2015 May 15;348(6236):799-803.
Mission Bay videoconference: MH-1405
September 29, 2016
Carlos Castellanos (student)
"un-TAM-ing the type 2 immune response"
Chan, P.Y., et al. "The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity." Science. 2016. Apr 1; 352(6281) 99-103.
Coaches: Ari Molofsky and Jeoung-Sook Shin
JJ Miranda (faculty)
"BETting on cancer therepeutic resistance"
Rathert P., et al. "Transcriptional plasticity promotes primary and acquired resistance to BET inhibition." Nature. 2015. Sep 24; 525(7570): 543-7.
Mission Bay videoconference: MH-1405
October 6, 2016
Jessica Cortez (student)
"Finding Memory: The Quest of the Forgetful Treg"
Van der Veeken, J et al. "Memory of Inflammation in Regulatory T cells." Cell. 2016 Aug 11; 166(4): 977-90.
Coaches: Michael Rosenblum and Alexander Marson
Tien Peng (faculty)
"Why is nothing happening? Maintenance of stem cell quiescence in adult organs"
Balasooriya, GI et al. "An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium." Dev Cell. 2016 Apr 4; 37(1): 85-97.
Mission Bay videoconference: MH-1405
October 13, 2016
Emily Davis (student)
"Astrocytic mitochondria are the powerhouse of neuronal cells (after stroke)"
Hayakawa, K., et al. "Transfer of mitochondria from astrocytes to neurons after stroke." Nature. 2016. Jul 28; 535: 551-555.
Coaches: Dena Dubal and Anna Molofsky
Biao Wang (faculty)
"Mitochondrial stress: friend or foe"
Berendzen KM, et al. "Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis." Cell. 2016. Sep 8; 166(6): 1553-1563.
Mission Bay videoconference: MH-1405
October 20, 2016
Andrea Eastes (student)
"The Mitobolome: A Snapshot of a Dynamic Powerhouse"
Chen, W et al. “Absolute Quantification of Matrix Metabolites Reveals the Dynamic of Mitochondrial Metabolism.” Cell. 2016 Aug 25; 166(5): 1324:1337.
Coaches: Rushika Perera and Jay Debnath
Ken Nakamura (faculty)
"Oxygen deprivation – a promising therapy for insufficient respiration ??"
Jain, IH et al. "Hypoxia as a therapy for mitochondrial disease." Science. 2016. Apr 1; 352(6281): 54-61.
Mission Bay videoconference: MH-1405
October 27, 2016
Kimberly Hoi (student)
"The Choroid Plexus: a window into brain aging"
Silva-Vargas V, et al. "Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells." Cell Stem Cell. 2016. Jul 19. pii: S1934-5909(16)30163-1.
Coaches: Arturo Alvarez-Buylla and Saul Villeda
Allison Xu (faculty)
"A ketone drink before your next marathon?"
Cox, P. et al. "Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes." Cell Metabolism. 2016. Aug 9; 24(2): 256-68.
Mission Bay videoconference: MH-1405
November 3, 2016
Alana Horowitz (student)
"I’m with Hangry: Tyrosine Hydroxylase Neurons make Feeding Great Again!"
Zhang, X and A.N. van den Pol. "Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis." Nature Neuroscience. 2016. 19(10): 1341-7.
Coaches: Saul Villeda and Allison Xu
Raymond Swanson (faculty)
"A portal promoting prion-like propagation of Parkinson pathology"
Mao, X et al. "Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3." Science. 2016 Sep 30; 353(6307).
Mission Bay videoconference: MH-1405
November 10, 2016
Rebecca Jaszczak (student)
"What’s in a dish? A mouse made by in vitro means still squeaks"
Hikabe, O. et al. "Reconstitution in vitro of the entire cycle of the mouse female germ line." Nature. 2016. Oct 17. doi: 10.1038/nature20104. [Epub ahead of print]
Coaches: Marco Conti and Miguel Ramalho-Santos
Mary Helen Barcellos-Hoff (faculty)
"RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers"
Nolen, E et al. "RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers." Nature Medicine. 2016. 22:933-939.
Mission Bay videoconference: MH-1405
November 17, 2016
Simone Kurial (student)
"Of Mice and Snakes: Progressive Loss of Function in a Limb Enhancer during Snake Evolution"
Kvon, Evgeny Z. et al. "Progressive Loss of Function in a Limb Enhancer during Snake Evolution." Cell. 2016. 167 (3):633-642.
Coaches: Holger Willenbring and Alex Marson
Jennifer Grandis (faculty)
"Mechanisms of Resistance to Tyrosine Kinase Inhibitors" with Dr. Dan Johnson
Miller, M et al. "Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance." Cancer Discover. 2016. 6(4): 382-99.
Mission Bay videoconference: MH-1405
December 1, 2016
Phi Nguyen (student)
"Total Recall: a shared neural ensemble links distinct contextual memories encoded close in time"
Cai, D. J. et al. "A shared neural ensemble links distinct contextual memories encoded close in time." Nature. 2016. 534: 115–118.
Coaches: Mazen Kheirbek and Loren Frank
David Solomon (faculty)
"Cohesin inactivation is a novel mechanism of resistance to targeted therapy in cancer"
Shen, C.H. et al. "Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma." Nature Medicine. 2016, 22(9): 1056-61.
Mission Bay videoconference: MH-1405
December 8, 2016
Tonatiuh Montoya (student)
"Unusual processing of snoRNAs and lncRNAs: it' sno joke"
Wu, H. et al. "Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins." Molecular Cell. 2016. 64(3): 534-548.
Coaches: Mary McMahon and Davide Ruggero
Trever Bivona (faculty)
"SHPing cancer out"
Ying-Nan, P. et al. "Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases." Nature. 2016. 535:148-152.
Mission Bay videoconference: MH-1405
January 12, 2017
Walter Mancia (student)
"Fear Erasure Facilitated by Immature Inhibitory Neuron Transplantation"
Yang, W.Z., et al. "Fear Erasure Facilitated by Immature Inhibitory Neuron Transplantation." Neuron. Nov 25 pii: S0896-62.
Coaches: Arturo Alvarez-Buylla and Georgia Panagiotakos
Mark Ansel (faculty)
"Aeroallergens slip through the cracks of dominant tolerance"
Bacher P, et al. "Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans." Cell. 2016 Nov 3; 167(4): 1067-1078.
Mission Bay videoconference: MH-1405
January 19, 2017
Andrew McKinney (student)
"A Variant on Copy Number Analyses: Cis-Regulatory Elements Instead of Gene Dosage"
Weischenfeldt J., et al. "Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking." Nature Genetics. 2017. 49: 65-74.
Coaches: Eric Collisson and Joseph Costello
Jay Debnath (faculty)
"KRAS and stress granules in cancer"
Grabocka, E. and D. Bar-Sagi. "Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules." Cell. 2016. 167(7):1803-1813.
Mission Bay videoconference: MH-1405
January 26, 2017
Andrew McNeal (student)
"A Hairy Situation: Regeneration of fat cells from myofibroblasts during wound healing"
Plikus, M. et al. "Regeneration of fat cells from myofibroblasts during wound healing." Science. 2017. Jan (DOI: 10.1126/science.aai8792).
Coaches: Rob Judson and Shingo Kajimura
Robert Blelloch (faculty)
"In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming"
Ocampo, A., et al. "In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming". Cell. 2016. 167(7):1719-1733.
Mission Bay videoconference: MH-1405
February 2, 2017
Tina Solvik (student)
"Putting a Damper on the FUNgi: DAPK1 and LAP"
Oikonomou V., et al. “Noncanonical fungal autophagy inhibits inflammation in response to IFN-γ via DAPK1.” Cell Host Microbe. 2016. 20: 744-757.
Coaches: Jay Debnath and Anita Sil
Joe Hiatt (student)
"How old are viruses?"
Aiewsakun P. and A. Katzourakis. "Marine origin of retroviruses in the early Palaeozoic Era." Nature Communications. 2017. doi:10.1038/ncomms13954
Coaches: Alex Marson and Joseph Bondy-Denomy
Mission Bay videoconference: MH-1405
February 9, 2017
Casey Beppler (student)
"Lymphocytes go home after dark: T and B Cell Circadian Clocks Control Trafficking"
Druzd, D., et al. "Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses." Immunity. 2017. 46(1): 120-132.
Coaches: Jason Cyster and Ying-Hui Fu
Mark Anderson (faculty)
"Display of chimeric “self” by the immune system"
Liepe, J., et al. "A large fraction of HLA Class I ligands are proteasome-generated spliced peptides." Science. 2016. 354(6310): 354-358.
Mission Bay videoconference: MH-1405
February 16, 2017
Ariane Panzer (student)
"Alternative Facts: Does Delivery Mode Influence Bacterial Attendance at the Inauguration of the Infant Microbiome?"
Chu, D.M., et al. “Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery.” Nature Medicine. 2017 Jan 23. doi: 10.1038/nm.4272. [Epub ahead of print].
Coaches: Susan Lynch and Peter Turnbaugh
Robert Raffai (faculty)
"High on Sugar, HSCs you Break my Heart"
Sarrazy, V., et al. "Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques of ApoE(-/-) Mice." Circulation Research. 2016. 118(7): 1062-77.
Mission Bay videoconference: MH-1405
February 23, 2017
Mark-Phillip Pebworth (student)
"Ask not for whom the brain folds: Gyrification in Cerebral Organoids"
Li, Y., et al. "Induction of Expansion and Folding in Human Cerebral Organoids." Cell Stem Cell. 2017. 20:1-12.
Coaches: Arnold Kriegstein and Arturo Alvarez-Buylla
Andy Chang (faculty)
"Sensing the urge to breathe"
Kumar, N.N., et al. "Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons." Science. 2015. 348(6240): 1255-60.
Mission Bay videoconference: MH-1405
March 2, 2017
Germaine Yong (student)
"May The Gut Microbes Be With You - Harnessing Your Gut Microbial Metacommunity To Maximize Nutritional Therapy"
Griffin, N., et al. "Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions." Cell Host & Microbe. 2017. 21(1): 84-96.
Coaches: Peter Turnbaugh and Suneil Koliwad
Licia Selleri (faculty)
"Human Organs from Beastly Animal Bodies"
Wu, J. et al. "Interspecies Chimerism with Mammalian Pluripotent Stem Cells." Cell. 2017. 168 (3): 473-486.
Mission Bay videoconference: MH-1405
March 9, 2017
Theodore Roth (student)
"Listen to your mother- chewing drives homeostatic oral immune responses"
Dutzan, N., et al. "On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier." Immunity. 2017. 46(1): 133-147.
Coaches: Alex Marson and Mark Anderson
Mission Bay videoconference: MH-1405
March 16, 2017
Breanna Allen (student)
"The Yin and Yang of Neuroimmune Response"
Liddelow, S.A., et al. "Neurotoxic reactive astrocytes are induced by activated microglia." Nature. 2017. 541: 481-487.
Coaches: Anna Molofsky and Matthew Spitzer
Patrick Schupp (student)
"Phage News: A New Paradigm in Inter-phage Communication during Infection"
Erez, Z., et al. Communication between viruses guides lysis–lysogeny decisions. Nature. 2017. 541: 488–493.
Coaches: Joseph Bondy-Denomy and Shaeri Mukherjee
Mission Bay videoconference: MH-1405
March 23, 2017
Jerika Barron (student)
"The original 3D cell culture: Using a humanized mouse brain to model Alzheimer’s"
Espuny-Camacho, I., et al. "Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain." Neuron. 2017. 93(5): 1066-1081.
Coaches: Eric Huang and Jen Yokoyama
Camile Simoneau (student)
"The true drought culprit: CD8+ T cells decrease reservoir size"
Takata, H., et al. "Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection." Science Translational Medicine. 2017. 9:(377).
Coaches: Melanie Ott and Trevor Burt
Mission Bay videoconference: MH-1405
March 30, 2017
Parinaz Fozouni (student)
"The elusive HIV reservoir: finding the latent needle in the haystack"
Descours, B., et al. “CD32a is a marker of a CD4 T-cell HIV reservoir harboring replication-competent proviruses.” Nature. 2017 Mar 15; doi:10.1038/nature21710.
Coaches: Melanie Ott and Maggie Feeney
Sara Sunshine (student)
"Past vs. Present: What Made the 2013-2016 Ebola Epidemic Different?"
Diehl, W. E., et al. "Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic." Cell. 2016. 167: 1088–1098.e6.
Coaches: Shaeri Mukherjee and Melanie Ott
Mission Bay videoconference: MH-1405
April 6, 2017
Elma Frias (student)
"When life gives you iPSCs, make microglia."
Pandya, H., et al. 2017. “Differentiation of Human and Murine Induced Pluripotent Stem Cells to Microglia-like Cells.” Nature Neuroscience. 2017. doi:10.1038/nn.4534. [Epub ahead of print]
Coaches: Susanna Rosi and Eric Huang
David Wu (student)
"Hey, keep your mom and dad jeans on! (Indecent) exposure of young neurons to recessive alleles."
Huang, W., et al. "Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain." Neuron. 2017. 93(5): 1094-1109.
Coaches: Daniel Lim and Alex Pollen
April 13, 2017
Anthony Venida (student)
"HIIT the gym! Your gene transcripts, ribosomal proteins, and mitochondrial gains will thank you later."
Robinson, M.M., et al. Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans. Cell Metabolism. 2017. 25(3), 581–592.
Coaches: Rushika Perera and Shingo Kajimura
Nicholas Gentry (student)
"A not-so-Summery tale: a Fall in molecular rhythmic consistency may Spring upon us in the Winter of our lives"
Lim, A.S.P., et al. "Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease." Nature Communications. 2017. 8(149310" 1-16.
Coaches: Louis Ptacek and Miguel Ramalho-Santos
Mission Bay videoconference: MH-1405
April 20, 2017
Jeanmarie Gonzalez (student)
"Flavivirus Family Feud: Prior exposure to Dengue enhances Zika infection"
Bardina, S.V., et al. "Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity." Science. 2017. Mar 30. pii: eaal4365.
Coaches: Shomyseh Sanjabi and Tiffany Scharschmidt
Elise Wolf (student)
"A double edged sword: PI3K inhibitors provide AID to lymphoma"
Compagno, M., et al. "“Phosphatidylinositol 3-Kinase δ Blockade Increases Genomic Instability in B Cells.” Nature. 2017. 542 (7642): 489–93.
Coaches: Jason Cyster and Ari Molofsky
Mission Bay videoconference: MH-1405
April 27, 2017
Kamir Hiam (student)
"Optimize Prime: T Cell Mediated Superclusters Transform Immunity"
Brewitz, A., et al. "CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.” Immunity. 2017. 46(2): 205–219.
Coaches: Matthew Spitzer and Jeong-Sook Shin
Jeremy Williams (student)
"Lending piece of mind: The pro-metastatic transfer of cGAMP from brain metastases to astrocytes"
Chen, Q., et al. "Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer." Nature. 2016. 533(7604), 493–498.
Coaches: Rushika Perera and Andrei Goga
Mission Bay videoconference: MH-1405
May 4, 2017
Karen Wong (student)
"Embodying Diversity: Friend or Foe?"
Morrissy, A., et al. "Spatial heterogeneity in medulloblastoma." Nature Genetics. 2017. 49: 780-788..
Coaches: Joe Costello and Pui Kwok
Mission Bay videoconference: MH-1405
May 11, 2017
Austin Hsu (student)
"Beats by Macrophage"
Hulsmans, M., et al. "Macrophages Facilitate Electrical Conduction in the Heart.” Cell. 2017. 169(3): 510-522.e520.
Coaches: Rahul Deo and Guo Huang
Erron Titus (student)
"Mess with your soul like ether: Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG"
Wang, W. and R. MacKinnon. "Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG." Cell. 2017. 169(3): 422-430.
Coaches: Rahul Deo and Michael Grabe
Mission Bay videoconference: MH-1405
May 18, 2017
Johnny Yu (student)
"DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome"
Aktas, T., et al. "DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome." Nature. 2017. 544: 115-119.
Coaches: Hani Goodarzi and Bassem Al-Sady
Alexis Krup (student)
"Flight of the interneurons: Recapitulating saltatory migration in forebrain spheroids"
Birey, F., et al. "Assembly of functionally integrated human forebrain spheroids." Nature. 2017. 545: 54-59.
Coaches: Michael Oldham and Julie Sneddon
Mission Bay videoconference: MH-1405
May 25, 2017
Geil Merana (student)
"All Downhill From Here: How Age-Associated Changes in the Microbiome Promote Immune Dysfunction"
Thevaranjan, N., et al. "Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction." Cell Host & Microbe. 2017. 21(4): 455–466.
Coaches: Susan Lynch and Tiffany Scharschmidt
Katherine Yu (student)
"Breaking it down: Finding the building blocks that regulate mRNA stability"
Yartseva, V. et al. "RESA identifies mRNA-regulatory sequences at high resolution." Nature Methods. 2017. 14(2): 201-207.
Coaches: Hani Goodarzi and David Erle
Mission Bay videoconference: MH-1405
June 1, 2017
Ramiro Patino (student)
"To be, or not to be curved, that is the question of Vibrio cholerae"
Bartlett, T. M., et al. "A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis." Cell. 2017. 168: 172–185.e15.
Coaches: Shaeri Mukherjee and Joanne Engel
Nikolai Zapero (student)
Consuming Youthful Ordure Each Day Keeps The Doctor Away: Life Span Regulation Through Gut Microbiota in the African Turquoise Killifish
Smith, P., et al. "Regulation of Life Span by the Gut Microbiota in The Short-Lived African Turquoise Killifish." bioRxiv. 2017. https://doi.org/10.1101/120980
Coaches: Saul Villeda and Peter Turnbaugh
Mission Bay videoconference: MH-1405
June 8, 2017
Wandi (Didi) Zhu (student)
"BAFFling Association with Autoimmunity Disorders"
Steri, M., et al. "Overexpression of the Cytokine BAFF and Autoimmunity Risk." 2017. N Engl J Med 376: 1615-1626.
Coaches: Mark Ansel and Marina Sirota
Katerina Popova (student)
"Can we just say translational control second? Dynamic control of protein synthesis during erythropoiesis"
Alvarez-Dominguez, J.R., X. Zhang, and W. Hu. "Widespread and dynamic translational control of red blood cell development." 2017. Blood 129(5): 619-629.
Coaches: Martin Kampmann and Hani Goodarzi
Mission Bay videoconference: MH-1405