BMS Journal Club 2022-23

2022-23 Journal Club Schedule

Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location:In person at N-225 on the Parnassus campus, with a livestream/Zoom option as well. The Zoom link will be sent out with the email reminder sent to the BMS listservs. Please contact Demian Sainz if you are not already on one of our listservs.
Links to previous livestreams and recorded video are in the sidebar.

September 8, 2022

*Introduction to Journal Club with Journal Club co-Chairs Bruce Wang and Tien Peng*

Meagan Olive (student)
"The right to choose: Gamma delta T cells take up residence in the decidua for a novel role in early pregnancy"
Yang, S., et al. Early pregnancy human decidua gamma/delta T cells exhibit tissue resident and specific functional characteristics. Mol Hum Reprod. 2022 Jul 29;28(8):gaac023. doi: 10.1093/molehr/gaac023. PMID: 35758607.
Coaches: Tiffany Scharschmidt, MD & David Raleigh, MD, PhD

September 15, 2022

Arun Wiita, MD, PhD (faculty)
"On cloud IL-9: Engineering a next-level T-cell for adoptive immunotherapy"
Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, Song D, Rommel PC, Radaelli E, Young RM, Leonard WJ, Ribas A, June CH, Garcia KC. Potentiating adoptive cell therapy using synthetic IL-9 receptors. Nature. 2022 Jul;607(7918):360-365. doi: 10.1038/s41586-022-04801-2. Epub 2022 Jun 8. PMID: 35676488; PMCID: PMC9283313.

Jun Hyung Sin (student)
"KAT7 bites down, marking chromatin regions of AIRE-regulated loci in TECs"
Melanie Heinlein, Luke C. Gandolfo, Kelin Zhao, Charis E. Teh, Nghi Nguyen, Jonathan B. Baell, Yael Goldfarb, Jakub Abramson, Johannes Wichmann, Anne K. Voss, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Daniel H. D. Gray The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance Science Immunology (21 Jan 2022, Vol. 7, Issue No. 67)
Coaches: Jay Gardner, MD, PhD & Tony Defranco, PhD

September 22, 2022

Ashish Raj, PhD (faculty)
Montal, Victor et al. "Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes" Science Translational Medicine vol 14.655 (2022) doi:10.1126/scitranslmed.abn7273

Max Foisey (student)
"Finally! An engineered cell therapy paper that isn't about T cells..."
Nahmad, Alessio D et al. “In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice.” Nature biotechnology vol. 40,8 (2022): 1241-1249. doi:10.1038/s41587-022-01328-9
Coaches: Jason Cyster, PhD & Luke Gilbert, PhD

September 29, 2022

Cathryn Cadwell, MD, PhD (faculty)
"Brain cell type atlases: The key to understanding neurobiology, or aimless stamp collecting?"
Berg, J., Sorensen, S.A., Ting, J.T. et al. Human neocortical expansion involves glutamatergic neuron diversification. Nature 598, 151–158 (2021).

Charlotte Wang (student)
"All types of screens: unmasking cancer"
Kishton, R. J., et al. (2022). Cancer genes disfavoring T cell immunity identified via integrated systems approach. Cell reports, 40(5), 111153.
Coaches: Julia Carnevale, MD & David Nguyen, MD, PhD

October 6, 2022

Matthew Stachler, MD, PhD (faculty)
"Determining the origins of esophageal adenocarcinoma. Big Data and complex manuscripts, trying to make sense of techniques you may not completely understand"
Nowicki-Osuch K, Zhuang L, Jammula S, Bleaney CW, Mahbubani KT, Devonshire G, Katz-Summercorn A, Eling N, Wilbrey-Clark A, Madissoon E, Gamble J, Di Pietro M, O'Donovan M, Meyer KB, Saeb-Parsy K, Sharrocks AD, Teichmann SA, Marioni JC, Fitzgerald RC. Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition. Science. 2021 Aug 13;373(6556):760-767. doi: 10.1126/science.abd1449. PMID: 34385390.

Kyla Foster (student)
"The Hitchhiker's Guide to the Brain: Glioblastoma Hijacks Neuronal Mechanisms for Brain Invasion"
Venkataramani V, Yang Y, Schubert MC, … Wick W, Kuner T, Winkler F. Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell. 2022 Aug 4;185(16):2899-2917.e31. doi: 10.1016/j.cell.2022.06.054. Epub 2022 Jul 31. PMID: 35914528.
Coaches:  Betsy Crouch, MD, PhD & Harish Vasudevan, MD, PhD 

October 13, 2022

Franklin Huang, MD, PhD (faculty)
"Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors"Nassar, A.H., Adib, E., Abou Alaiwi, S. et al. Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors, Cancer Cell,2022, ISSN 1535-6108,\

Rita Loudermilk (student)
"Shining a Light on Cell-Cell Interactions"
Oslund, R.C., Reyes-Robles, T., White, C.H. et al. Detection of cell–cell interactions via photocatalytic cell tagging. Nat Chem Biol 18, 850–858 (2022).
Coaches: Alexis Combes, PhD & Gabi Fragiadakis, PhD

October 20, 2022

Xin Duan, PhD (faculty)
"May the force be with your neurons at the right moment"
Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures in a Mouse Model of Arthrogryposis
Shang Ma, et al,  Ardem Patapoutian (Biorxiv, 2022)

Evan Semenza (student)
"This is your brain on (fatty) acid: metabolic involvement in the evolutionary expansion of the cerebral cortex"
Pinson, A., et al. (2022) Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. Science 377(6611).
Coaches: Corey Harwell, PhD & Daniel Lim, MD, PhD

October 27, 2022

Frank McCormick, PhD (faculty)
"Selfish Mutations and germline disease"
Maher GJ, Ralph HK, Ding Z, Koelling N, Mlcochova H, Giannoulatou E, Dhami P, Paul DS, Stricker SH, Beck S, McVean G, Wilkie AOM, Goriely A. Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes. Genome Res. 2018 Dec;28(12):1779-1790. doi: 10.1101/gr.239186.118. Epub 2018 Oct 24. PMID: 30355600; PMCID: PMC6280762.

Wendy Hung (student)
"Waste not, want not: glycolysis byproduct boosts anti-tumor immunity"
Feng, Q., Liu, Z., Yu, X. et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun 13, 4981 (2022).
Coaches: Rachel Rutishauser, MD, PhD & Sara Suliman, PhD, MPH

November 3, 2022

Timothy Henrich, MD (faculty)

Caroline Whitty (student)
"I'll have the de-CAF"
Krishnamurty, A.T., Shyer, J.A., Thai, M. et al. LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature (2022).

Coaches: Dean Sheppard, MD & Eric Collisson, MD

November 10, 2022

Jialing Liu, PhD (faculty)
J. Terreros-Roncal, E. P. Moreno-Jiménez, M. Flor-García, C. B. Rodríguez-Moreno,  M. F. Trinchero, B. Márquez-Valadez, F. Cafini, A. Rábano, M. Llorens-Martín. 
Science 2021 374:1106-1113. 


William Xie (student)
"T cells and Glia: Eng-aging in white matter"
Kaya, T., Mattugini, N., Liu, L. et al. CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci (2022).
Coaches: Andrew Yang, PhD & Ari Molofsky, MD, PhD

November 17, 2022

Adrian Erlebacher, MD, PhD (faculty)
"Brush your teeth to prevent arthritis"
Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. 
Li X, Wang H, Yu X, Saha G, Kalafati L, Ioannidis C, Mitroulis I, Netea MG, Chavakis T, Hajishengallis G. Cell. 2022 May 12;185(10):1709-1727.e18. doi: 10.1016/j.cell.2022.03.043. Epub 2022 Apr 27. PMID: 35483374

Stephanie Huard (student)
Colombo, G., Cubero, R.J.A., Kanari, L. et al. A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes. Nat Neurosci 25, 1379–1393 (2022).
Coaches: Dena Dubal, MD, PhD & Eric Huang, MD, PhD

December 1, 2022

Shibani Pati, MD, PhD (faculty)
"Treating Brain Cancer with Anti-histamines"
Chen J, Liu G, Wang X, Hong H, Li T, Li L, Wang H, Xie J, Li B, Li T, Lu D, Zhang Y, Zhao H, Yao C, Wen K, Li T, Chen J, Wu S, He K, Zhang WN, Zhao J, Wang N, Han Q, Xia Q, Qi J, Chen J, Zhou T, Man J, Zhang XM, Li AL, Pan X. Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling. Cell Stem Cell. 2022 Nov 3;29(11):1531-1546.e7. doi: 10.1016/j.stem.2022.09.009. Epub 2022 Oct 19. PMID: 36265493.

Kevin Ly (student)
"Have I seen you before? I think you need to be Trm'ed."
Fung HY, Teryek M, Lemenze AD, Bergsbaken T. CD103 fate mapping reveals that intestinal CD103- tissue-resident memory T cells are the primary responders to secondary infection. Sci Immunol. 2022 Nov 11;7(77):eabl9925. doi: 10.1126/sciimmunol.abl9925. Epub 2022 Nov 4. PMID: 36332012.
Coaches: Ari Molofsky, MD, PhD & Rachel Rutishauser, MD, PhD

December 8, 2022

Letitia Yang (student)
Robinson, M. J., Dowling, M. R., Pitt, C., O’Donnell, K., Webster, R. H., Hill, D. L., Ding, Z., Dvorscek, A. R., Brodie, E. J., Hodgkin, P. D., Quast, I., Tarlinton, D. M. (2022). Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response. Science Immunology, 7(76).
Coaches: Julie Zikherman, MD & Jason Cyster, PhD

Holly Steininger (student)
"Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells"
Sara S Oltra, Laura Sin, Sara Colomo, María Pérez-López, Angela Molina-Crespo, Kyoung-Han Choi, Lidia Martinez, Saleta Morales, Cristina González-Paramos, Alba Orantes, Mario Soriano, Alberto Hernandez, Ana Lluch, Federico Rojo, Joan Albanell, Jae-Kyun Ko, David Sarrió, Gema Moreno-Bueno
Coaches: Erin Gordon, MD & Susan Lynch, PhD

January 26, 2023

Sophia Nelson (student)
"Fancy MAIT-ing you here: uncovering a new role for MAIT cells in meningeal homeostasis and cognitive function"
Zhang, Y., Bailey, J.T., Xu, E. et al. Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function. Nat Immunol 23, 1714–1725 (2022).
Coaches: Ari Molofsky, MD, PhD & Andrew Yang, PhD 

February 2, 2023

Samuel Hoelscher (student)
"Life in Plastic, Not Fantastic"
Chan, J. M., Zaidi, S., Love, J. R., Zhao, J. L., Setty, M., Wadosky, K. M., Gopalan, A., Choo, Z.-N., Persad, S., Choi, J., LaClair, J., Lawrence, K. E., Chaudhary, O., Xu, T., Masilionis, I., Linkov, I., Wang, S., Lee, C., Barlas, A., … Sawyers, C. L. (2022). Lineage plasticity in prostate cancer depends on JAK/stat inflammatory signaling. Science, 377(6611), 1180–1191. 
Coaches: Rohit Bose, MD, PhD & Catherine Smith, MD

Nav Lally (student)
"Setting the Clock on Segmentation: The Influence of Metabolism on Species-Specific Developmental Rates"
Diaz-Cuadros, M., Miettinen, T.P., Skinner, O.S. et al. Metabolic regulation of species-specific developmental rates. Nature 613, 550–557 (2023).
Coaches: Guo Huang, PhD & Vasanth Vedantham, MD, PhD

February 9, 2023

Letitia Yang (student)
"Uncovering the kinetics of long-lived plasma cells in the bone marrow"
Robinson, M. J., Dowling, M. R., Pitt, C., O’Donnell, K., Webster, R. H., Hill, D. L., Ding, Z., Dvorscek, A. R., Brodie, E. J., Hodgkin, P. D., Quast, I., Tarlinton, D. M. (2022). Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response. Science Immunology, 7(76).
Coaches: Julie Zikherman, MD & Jason Cyster, PhD

Lexi Schneider (student)
"Reduce, Reuse, Recycle: An Eco-Friendly Approach to Humoral Immunity"
Schiepers, A. et al. Molecular fate-mapping of serum antibody responses to repeat immunization. Nature 1–3 (2023) doi:10.1038/s41586-023-05715-3.

Coaches: Andrew Yang, PhD & Jason Cyster, PhD

February 16, 2023

Serena Lu (student)
"A 'Sweet' Role of Glucose in mRNA Splicing and Tissue Differentiation"
Miao, W., Porter, D.F., Lopez-Pajares, V., Siprashvili, Z., Meyers, R.M., Bai, Y., Nguyen, D.T., Ko, L.A., Zarnegar, B.J., Ferguson, I.D., et al. (2023). Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation. Cell 186, 80-97.e26.
Coaches: Stephen Floor, PhD & Erica Hutchins, PhD

Zack Mullin-Bernstein (student)
"How Did We Get Here? Building Spindles in a World Without Directions"
Fukuyama, T. et al. Morphological growth dynamics, mechanical stability, and active microtubule mechanics underlying spindle self-organization. Proc. Natl. Acad. Sci. U. S. A. 119, e2209053119 (2022)
Coaches: Fred Chang, MD, PhD & Torsten Wittmann, PhD

February 23, 2023

Jingwen Ding (student)
"DNA repair induces aging through epigenetic alterations"
Yang, Jae-Hyun et al. “Loss of epigenetic information as a cause of mammalian aging.” Cell vol. 186,2 (2023): 305-326.e27. doi:10.1016/j.cell.2022.12.027
Coaches: Abby Buchwalter, PhD & Saul Villeda, PhD

Maddie Urbanek (student)
"Dancing through development: TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages"
Espinosa-Medina I, Feliciano D, Belmonte-Mateos C, Linda Miyares R, Garcia-Marques J, Foster B, Lindo S, Pujades C, Koyama M, Lee T. TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages. Neuron. 2022 Nov 18:S0896-6273(22)00995-3. doi: 10.1016/j.neuron.2022.10.035. Epub ahead of print. PMID: 36417906.
Coaches: Ryan Corces, PhD & Mercedes Paredes, MD, PhD

March 2, 2023

McKenzie Daanen (student)
"Circadian Rhythm and Blues: Dendritic cell circadian rhythm directs anti-tumor immune response"
Wang, C., Barnoud, C., Cenerenti, M. et al. Dendritic cells direct circadian anti-tumour immune responses. Nature (2022).
Coaches: Matthew Spitzer, PhD & Karin Pelka, PhD

Khang Nguyen (student)
"Regulatory T cell Fitness Decision via Deubiquitination for TME attrition"
Montauti, E., Weinberg, S. E., Chu, P., Chaudhuri, S., Mani, N. L., Iyer, R., Zhou, Y., Zhang, Y., Liu, C., Xin, C., Gregory, S., Wei, J., Zhang, Y., Chen, W., Sun, Z., Yan, M., & Fang, D. (2022). A deubiquitination module essential for Treg fitness in the tumor microenvironment. Science advances, 8(47), eabo4116.
Coaches: Qizhi Tang, PhD & Karin Pelka, PhD

March 9, 2023

Kai Trepka (student)
"I've got your bac: E. coli degradation of a toxic drug rescues growth of Fusobacterium and cancer cells"
LaCourse, Kaitlyn et al. "The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota." Cell Reporters vol. 41,7 (2022):111625. doi: 10.1016/j.celrep.2022.111625.
Coaches: Rohit Bose, MD, PhD & Peter Turnbaugh, PhD

Minna Apostolova (student)
“Working 9 to CD5: dendritic cells expressing CD5 improve response to immune checkpoint blockade therapy in cancer”
He, Mingyu et al. “CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses.” Science (New York, N.Y.) vol. 379,6633 (2023): eabg2752. doi:10.1126/science.abg2752. 
Coaches: Matt Spitzer, PhD & Kole Roybal, PhD

March 16, 2023

Jayden Ross (student)
"Use it and Lose it: Activity-Induced DNA Damage and Repair Mechanisms In Neurons"
Pollina, E.A., Gilliam, D.T., Landau, A.T. et al. A NPAS4–NuA4 complex couples synaptic activity to DNA repair. Nature 614, 732–741 (2023).
Coaches: Cathryn Cadwell, MD, PhD & TBD

Ivan Chavez (student)
"Nothing nano about these particles! Big changes for coronavirus vaccine design?"
A. A. Cohen*, N. van Doremalen*, A. J. Greaney, H. Andersen, A. Sharma, T. N. Starr, J. R. Keeffe, C. Fan, J. E. Schulz, P. N. P. Gnanapragasam, L. M. Kakutani, A. P. West, G. Saturday, Y. E. Lee, H. Gao, C. A. Jette, M. G. Lewis, T. K. Tan, A. R. Townsend, J. D. Bloom, V. J. Munster, P. J. Bjorkman, Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models. Science. 377, eabq0839 (2022).
Coaches: Angela Phillips, PhD & Sara Suliman, PhD, MPH

March 23, 2023

Kadellyn Sandoval Gutierrez (student)
"We don't fit in our genes: Epigenetic mechanism behind transgenerational BPA-induced obesity"
Yoon Hee Jung et al. Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity. PNAS. 119(50). 2022.
Coaches: Mercedes Paredes, MD, PhD & Tomasz Nowakowski, PhD

Amy Chen (student)
“CLASH” of the T cells: A Cas12a screening approach identifies PRDM1 Δexon3 as a regulator of CAR T exhaustion"
Dai, X., Park, J.J., Du, Y. et al. Massively parallel knock-in engineering of human T cells. Nat Biotechnol (2023).
Coaches: Sagar Bapat, MD, PhD & Arun Wiita, MD, PhD

March 30, 2023

Julianne Riggs (student)
"Tale of the Ten-Year Experiment"
Soerens, A.G., Künzli, M., Quarnstrom, C.F. et al. Functional T cells are capable of supernumerary cell division and longevity. Nature (2023).
Coaches: Tiffany Scharschmidt, MD & Qizhi Tang, PhD

Li Wang (student)
"Don’t leave me on read—regulation of antitumor immunity by m6A reader in macrophage"
Ma, S., Sun, B., Duan, S. et al. YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells. Nat Immunol 24, 255–266 (2023).
Coaches: Robert Blelloch, MD, PhD & Caroline Vissers, PhD

April 6, 2023

Amrik Kang (student)
"The missing ‘link’ for cancer immunotherapy? LINK CAR-T cells as a logic-gated cancer treatment"
Tousley, A.M., Rotiroti, M.C., Labanieh, L. et al. Co-opting signalling molecules enables logic-gated control of CAR T cells. Nature 615, 507–516 (2023).
Coaches: Arun Wiita, MD, PhD & Justin Eyquem, PhD

Riana Hunter (student)
"Liver stage malaria... with some fava beans and a nice chianti: Interplay between liver stage and blood stage of Plasmodium infection dictate malaria severity"
Ângelo Ferreira Chora, et al. "Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis". Immunity (2023):
Coaches: Margaret Feeney, MD & Rachel Rutishauser, MD, PhD

April 13, 2023

Gary Chan (student)
" 'Eureka!' - said the CD8 memory T-cells"
Arkatkar, T., Davé, V.A., Talavera, I.C. et al. Memory T cells possess an innate-like function in local protection from mucosal infection. J Clin Invest 0021-9738 (2023).
Coaches: Rachel Rutishauser, MD, PhD & Alexis Combes, PhD

James Asaki (student)
Murakami, K., Hamazaki, N., Hamada, N. et al. Generation of functional oocytes from male mice in vitro. Nature (2023).
Coaches: Jennifer Fung, PhD,  Diana Laird, PhD & Leanne Jones, PhD

April 20, 2023

Jing Chung (student)
"Taming IL-2 with acidity: an IL-2 mutein with pH-specific anti-tumor activity."
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. PMID: 36459543.
Coaches: Max Krummel, PhD & Matt Spitzer, PhD

Madison Lotstein (student)
"Shooting for the Stars with STARmap PLUS"
Zeng, H., Huang, J., Zhou, H. et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nat Neurosci 26, 430–446 (2023).
Coaches: Andrew Yang, PhD & Marina Sirota, PhD

April 27, 2023

Mingyang Ma (student)
"How an anxious heart talks to the brain"
Hsueh, B., Chen, R., Jo, Y. et al. Cardiogenic control of affective behavioural state. Nature 615, 292–299 (2023).
Coaches: Ritchie Chen, PhD, MSc, BS & Guo Huang, PhD

Jaela Caston (student)
"The superSTAR of the brain: Astrocytes mediate aberrant firing of human FXS neurons"
Sharma SD, Reddy BK, Pal R, Ritakari TE, Cooper JD, Selvaraj BT, Kind PC, Chandran S, Wyllie DJA, Chattarji S. Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons. Cell Rep. 2023 Apr 4;42(4):112344. doi: 10.1016/j.celrep.2023.112344. Epub ahead of print. PMID: 37018073.
Coaches: Corey Harwell, PhD & Betsy Crouch, MD, PhD

May 4, 2023

Sara Misiukiewicz (student)
"Cell State Wars: A New Hope for preventing T cell exhaustion via the SWI/SNF complex"
Battistello E, Hixon KA, Comstock DE, Collings CK, Chen X, Rodriguez Hernaez J, Lee S, Cervantes KS, Hinkley MM, Ntatsoulis K, Cesarano A, Hockemeyer K, Haining WN, Witkowski MT, Qi J, Tsirigos A, Perna F, Aifantis I, Kadoch C. Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion. Mol Cell. 2023 Mar 15:S1097-2765(23)00153-3. doi: 10.1016/j.molcel.2023.02.026. Epub ahead of print. PMID: 36944333.
Coaches: Karin Pelka, PhD & Justin Eyquem, PhD

Zachary Stensland (student)
"Smooth like butter, like cancer's gone undercover"
Zheng, X., Hou, Z., Qian, Y. et al. Tumors evade immune cytotoxicity by altering the surface topology of NK cells. Nat Immunol (2023).
Coaches: Gabi Fragiadiks, PhD & Matt Spitzer, PhD

May 11, 2023

Isabel Shen (student)
"Another CAR paper?? You thought!"
Zhang, D. et al. PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. Cell Metab (2023).
Coaches: Alexis Combes, PhD & Gabi Fragiadakis, PhD

Manon Miller (student)
"ARID1A loss induces an immunosuppressive tumor microenvironment"
Li, N., Liu, Q., Han, Y. et al. ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression. Nat Commun 13, 7281 (2022).
Coaches: Katherine Fuh, MD, PhD & Rohit Bose, MD, PhD

May 18, 2023

Rukman Thota (student)
"A Pirates Favorite Tumor Model." 
Ng, K. W. et al. Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature (2023). doi:10.1038/s41586-023-05771-9
Coaches: Max Krummel, PhD & Jason Cyster, PhD

Gabriella Kimmerly (student)
"GRAB & go: germline encoded amino acid-binding motifs explain viral public epitopes"
Ellen L. Shrock et al., Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses. Science380,eadc9498(2023).DOI:10.1126/science.adc9498
Coaches: Angela Phillips, PhD & Rachel Rutishauser, MD, PhD

May 25, 2023

Sarah Castro (student)
"Ageing gracefully: Cap2 suppresses the innate immune response"
Despic, V., Jaffrey, S.R. mRNA ageing shapes the Cap2 methylome in mammalian mRNA. Nature 614, 358-366 (2023).
Coaches: Mark Ansel, PhD & Stephen Floor, PhD

Holly Steininger (student)
"Doctors hire new Staph to fight cancer"
Y. Erin Chen et al. Engineered skin bacteria induce antitumor T cell responses against melanoma.Science380, 203-210(2023).DOI:10.1126/science.abp9563.
Coaches: Tiffany Scharschmidt, MD & Susan Lynch, PhD

June 1, 2023

Jun Hyung Sin (student)
"Karing to know: embryonic keratin19 mTEC-progenitor give rise to diversity in the adult thymic medulla"
Lucas B, White AJ, Klein F, Veiga-Villauriz C, Handel A, Bacon A, Cosway EJ, James KD, Parnell SM, Ohigashi I, Takahama Y, Jenkinson WE, Hollander GA, Lu WY, Anderson G. Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla. Nat Commun. 2023 Apr 12;14(1):2066. doi: 10.1038/s41467-023-37589-4. PMID: 37045811; PMCID: PMC10097809.

Coaches: Michael Waterfield, MD, PhD & Corey Miller, MD, PhD

Victoria Bowcut (student)
"When it comes to GPCR signaling, the third loop's the charm!" 
Sadler, F., Ma, N., Ritt, M. et al. Autoregulation of GPCR signalling through the third intracellular loop. Nature 615, 734–741 (2023).
Coaches: Kevan Shokat, PhD & Frank McCormick, PhD, FRS

June 8, 2023

Stephanie Huard (student)
"Shape: Another Frontier (Exploring Microglial Phenotypes with morphOMICs)"
Colombo, G., Cubero, R.J.A., Kanari, L. et al. A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes. Nat Neurosci 25, 1379–1393 (2022).
Coaches: Dena Dubal, MD, PhD & Eric Huang, MD, PhD

Anita Qualls (student)
"Do you like my LIPSTIC: A universal recording of in vivo cell-cell contacts via 'kiss and run' "
Nakandakari-Higa, S., Canesso, M. C. C., Walker, S., Chudnovskiy, A., Jacobsen, J. T., Parigi, S. M., ... & Victora, G. D. (2023). Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics. bioRxiv, 2023-03.
Coaches: Jay Gardner, MD, PhD & Sagar Bapat, MD, PhD