BMS Journal Club 2021-22

BMS Journal Club presentations are available via livestream and recorded video. UCSF MyAccess login is required.

**Zoom recordings from before 10/7/2021 can be found on the BMS Intranet site.

September 9, 2021

*Introduction to Journal Club with JC Chairs Bruce Wang and Tien Peng*

Dave Toczyski, Ph.D. (Faculty)
“Mitocytosis: Cells leave a trail of organellar jetsam” 
Jaio et al, “Mitocytosis, a migrasome-mediated mitochondrial quality-control process.” 2021 Cell May 27: 184(11):2896-2910.e13.

Joe Germino (Student)
"Expanding the throughput of single cell transcriptomics via combinatorial preindexing"
Datlinger, P., Rendeiro, A.F., Boenke, T. et al. Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing. Nat Methods18, 635–642 (2021).
Coaches: Vasilis Ntranos, Ph.D. and Jimmie Ye, Ph.D.

September 16, 2021

Elphege-Pierre Nora, Ph.D. (Facutly)
"Nonlinear control of transcription through enhancer-promoter interactions"
Jessica Zuin, Gregory Roth, Yinxiu Zhan, Julie Cramard, Josef Redolfi, Ewa Piskadlo, Pia Mach, Mariya Kryzhanovska, Gergely Tihanyi, Hubertus Kohler, View ORCID ProfilePeter Meister, Sebastien Smallwood, Luca Giorgetti

Gabi Reeder (Student)
"Painting the chromatin landscape for optimal CAR T cell function"
Seo, H., González-Avalos, E., Zhang, W. et al. BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells. Nat Immunol 22, 983–995 (2021).
Coaches: Justin Eyquem, Ph.D. and Rachel Rutishauser, M.D., Ph.D.

September 23, 2021

Shaeri Mukherjee, Ph.D. (Faculty)
"Traveling waves: how bacterial pathogens rewire host membranes"
Hsieh, Ting-Sung, Lopez, Victor A., Black, Miles H., et al. Science. 2021 May 28;372(6545):935-941.

Marilyn Steyert (Student)
"Could've had a V1: Vision is required for cell-type specification in the visual cortex"
Cheng, S., Butrus, S., Xu, V., Sagireddy, S., Tan, L., Shekhar, K., & Zipursky, S. L. (2021). Vision is Required for Cell Type Specification in the Visual Cortex. bioRxiv.
Coaches: Tomasz Nowakowski, Ph.D. and Michael Oldham, Ph.D.

September 30, 2021

Thea Mauro, M.D. (Facutly)
Ode to Salt: Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity.
András Maifeld, Johannes Wild, Tine V. Karlsen,et al. Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity, Journal of Investigative Dermatology, 2021,ISSN 0022-202X,

Rachel Rock (Student)
Han, S., Van Treuren, W., Fischer, C.R. et al. A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature 595, 415–420 (2021).
Coaches: Peter Turnbaugh, Ph.D. and Shaeri Mukherjee, Ph.D

October 7, 2021

Tammy T. Chang, M.D., Ph.D. (Facutly)
"Organoids are the future of transplantation"
Sampaziotis F, Muraro D, Tysoe OC, et al. Cholangiocyte organoids can repair bile ducts after transplantation in the human liver. Science (New York, N.Y.). 2021 Feb;371(6531):839-846. DOI: 10.1126/science.aaz6964.

Maya Arce (Student)
"Searching far and wide: Identification of functional SNPs and their ties to heritable traits"
Võsa, U., Claringbould, A., Westra, HJ. et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat Genet 53, 1300–1310 (2021).
Coaches: Marina Sirota, Ph.D. and Lauren Weiss, Ph.D

October 14, 2021

Aaron Tward, M.D., Ph.D. (Facutly)
“Towards the holy (en)grail of mammalian tissue regeneration”
Maksim V. Plikus, et al. Fibroblasts: Origins, definitions, and functions in health and disease, Cell, 184, 15, (3852-3872), (2021).

Shenghuan Sun (Student)
"From Brain to Information: single-cell level integrative multi-omics studies"
Morabito, S., Miyoshi, E., Michael, N. et al. Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease. Nat Genet 53, 1143–1155 (2021).
Coach: Ryan Corces, Ph.D. and Zicheng Hu, Ph.D.

October 28, 2021

Qili Liu, Ph.D. (Faculty)
"The microbiome-gut-brain axis and protein hunger"
Kim, B., Kanai, M.I., Oh, Y. et al. Response of the microbiome–gut–brain axis in Drosophila to amino acid deficit. Nature 593, 570–574 (2021).

Timmy Suh (Student)
"Single-cell Ribo-seq: Resolving the translatome at the cellular level to illuminate differential regulatory dynamics"
VanInsberghe, M., van den Berg, J., Andersson-Rolf, A., Clevers, H., & van Oudenaarden, A. (2021). Single-cell Ribo-seq reveals cell cycle-dependent translational pausing. Nature, 597(7877), 561–565.

November 4, 2021

Jayanta Debnath, M.D. (Faculty)
"Phase separation of glycogen and liver cancer"
Liu et al (2021). Glycogen accumulation and phase separation drives liver tumor initiation. Cell.  184, 1–18. Online ahead of print. Oct 21 2021.

Molly Bassette (Student)
"Synergistic Cancer Immunotherapy: Does Teamwork Make the Dream Work?"
Del Pogetto, E., et al. (2021). Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science, 373(6561).
Coaches: Karin Pelka, Ph.D. and Max Krummel, Ph.D.

November 18, 2021

Carlo Condello, Ph.D. (Faculty)
"Hungry Hungry Micros"
Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, Palleis C, Rauchmann BS, Gildehaus FJ, Lindner S, Spitz C, Franzmeier N, Baumann K, Rominger A, Bartenstein P, Ziegler S, Drzezga A, Respondek G, Buerger K, Perneczky R, Levin J, Höglinger GU, Herms J, Haass C, Brendel M. Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases. Sci Transl Med. 2021 Oct 13;13(615):eabe5640. doi: 10.1126/scitranslmed.abe5640. Epub 2021 Oct 13. PMID: 34644146.

Hannah Driks (Student)
"Lessons in self-control: CD8+ T cells release self-suppressing extracellular vesicles during inflammation"
Schneider, E., Winzer, R., Rissiek, A. et al. CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression. Nat Commun 12, 5911 (2021).
Coaches: Melissa Reeves, Ph.D. and Rushika Perera, Ph.D.

December 2, 2021

Zach Gardell (Student)
"A RoadMAP for MAPT"
Bowles, K. R. et al. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell 184, 4547-4563.e17 (2021).
Coaches: Tom Nowakowski, PhD and Yadong Huang, MD, PhD

Nicholas Carey (Student)
“PANINI MIBI: Melting Together Protein & Nucleic Acid Imaging”
Virus-Dependent Immune Conditioning of Tissue Microenvironments
Sizun Jiang, Chi Ngai Chan, Xavier Rovira-Clave, Han Chen, Yunhao Bai, Bokai Zhu, Erin McCaffrey, Noah F. Greenwald, Candace Liu, Graham L Barlow, Jason L.Weirather, John Paul Oliveria, Darci Philips, Nilanjan Mukherjee, Kathleen Busman-Sahay, Michael Nekorchuk, Margaret Terry, Skyler Younger, Marc Bosse, JanosDemeter, Yury Golstev, David Robert McIlwain, Michael Angelo, Jacob D. Estes, Garry P. Nolan
bioRxiv 2021.05.21.444548

Coaches: Rachel Rutishauser, MD, PhD and Nadia Roan, PhD

December 9, 2021

Megan Scantlen (Student)
"It's not all about neurons, a new role for enteric glia"
Baghdadi, M.B., et al., Enteric glial cell heterogeneity regulates intestinal stem cell niches. Cell Stem Cell, 2021.
Coaches: Faranak Fattahi, PhD and Michael Kattah, MD, PhD

Sofia Caryotakis (Student)
"Neuroregenerative Neutrophils in CNS Injury"
Sakamoto, K., Jin, S. P., Goel, S., Jo, J. H., Voisin, B., Kim, D., Nadella, V., Liang, H., Kobayashi, T., Huang, X., Deming, C., Horiuchi, K., Segre, J. A., Kong, H. H., & Nagao, K. (2021). Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction. Immunity, 54(10), 2321–2337.e10. 
Coaches: Tiffany Scharschmidt, MD, PhD, and Ari Molofsky, PhD

January 6, 2022

Amy Chen (Student)
“Outsmarting the immune system: inactivation of the miRNA machinery protects tumor cells from T-cell mediated cytotoxicity"
Song, TY., Long, M., Zhao, HX. et al. Tumor evolution selectively inactivates the core microRNA machinery for immune evasion. Nat Commun 12, 7003 (2021)
Coaches: Melissa Reeves, PhD & Robert Blelloch, MD, PhD

Hanson Tam (Student)
"B cells unTEThered, lymphoma unleashed"
Shukla, V., Samaniego-Castruita, D., Dong, Z. et al. TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures. Nat Immunol 23, 99–108 (2022).
Coaches: Jason Cyster, PhD & Mark Ansel, PhD

January 13, 2022

Holly Steininger (Student)
"Let Food be thy Medicine: Microbiota-Directed Food Intervention for Undernourished Children"
Chen, R. Y., Mostafa, I., Hibberd, M. C., Das, S., Mahfuz, M., Naila, N. N., ... & Gordon, J. I. (2021). A microbiota-directed food intervention for undernourished children. New England Journal of Medicine, 384(16), 1517-1528.
Coaches: Susan Lynch, PhD & Saul Villeda PhD

Meagan Olive (Student)
"Defense Against the Oxidative Arts: Mtb Resistance is More Than Magic"
Lien, K. A., Dinshaw, K., et al. (2021). A nanocompartment system contributes to defense against oxidative stress in Mycobacterium tuberculosis. eLife. doi: 10.7554/eLife.74358
Coaches: Sara Suliman, PhD & Maggie Feeney, MD

January 20, 2022

Iris Chin (Student)
"I(GF2R) don’t know about you, but I’m feeling (CD)22: A role for sCD22 and IGF2R in microglial lysosome dysfunction"
Pluvinage, J. V., Sun, J., Claes, C., Flynn, R. A., Haney, M. S., Iram, T., Meng, X., Lindemann, R., Riley, N. M., Danhash, E., Chadarevian, J. P., Tapp, E., Gate, D., Kondapavulur, S., Cobos, I., Chetty, S., Pașca, A. M., Pașca, S. P., Berry-Kravis, E., Bertozzi, C. R., Blurton-Jones, M., Wyss-Coray, T. (2021). The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick Type C. Science Translational Medicine, 13(622):eabg2919.
Coaches: Martin Kampmann, PhD & Lennart Mucke, MD

Stephanie Huard (Student)
"Microglia in the Middle: Trem2 in Alzheimer's Pathogenesis"
Lee SH, Meilandt WJ, Xie L, Gandham VD, Ngu H, Barck KH, Rezzonico MG, Imperio J, Lalehzadeh G, Huntley MA, Stark KL, Foreman O, Carano RAD, Friedman BA, Sheng M, Easton A, Bohlen CJ, Hansen DV. Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology. Neuron. 2021 Apr 21;109(8):1283-1301.e6. doi: 10.1016/j.neuron.2021.02.010. Epub 2021 Mar 5. PMID: 33675684.
Coaches: Carlo Condello, PhD & Balyn Zaro, PhD

January 27, 2022

Leanne Jones (Faculty)
“Taking a shot at improving Healthspan”
Suda, M., Shimizu, I., Katsuumi, G. et al. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat. Aging 1, 1117-1126 (2021).

Grace Hernandez (Student)
"Highway to H(C)ell: Nanotubular highways transfer mitochondria from T-cells to cancer cells"
Saha, T., Dash, C., Jayabalan, R. et al. Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells. Nat. Nanotechnol. (2021). 
Coaches: Rushika Perera, PhD & Emily Goldberg, PhD

February 3, 2022

Demi Sandel (Student)
"Targeting epigenetic programs to evade exhaustion"
Prinzing, Brooke et al. “Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity.” Science translational medicine,(2021).
Coaches: Rachel Rutishauser, MD, PhD & Matt Spitzer, PhD

Laura Dwyer (Student)
"Biochem 101: MTHFD2's role in T cell fate, function, and metabolism"
Sugiura, A., Andrejeva, G., Voss, K., Heintzman, D.R., Xu, X., Madden, M.Z., Ye, X., Beier, K.L., Chowdhury, N.U., Wolf, M.M., et al. (2022). MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity 55, 65-81.e9.
Coaches: Alexis Combes, PhD & Joanna Halkias, MD

February 10, 2022

Max Krummel, Ph.D. (Faculty)
“Putting Some Labels on Pavlovian Immunity in the Brain”
Koren T, Yifa R, Amer M, Krot M, Boshnak N, Ben-Shaanan TL, Azulay-Debby H, Zalayat I, Avishai E, Hajjo H, Schiller M, Haykin H, Korin B, Farfara D, Hakim F, Kobiler O, Rosenblum K, Rolls A. Insular cortex neurons encode and retrieve specific immune responses. Cell. 2021 Nov 24;184(24):5902-5915.e17. doi: 10.1016/j.cell.2021.10.013. Epub 2021 Nov 8. Erratum in: Cell. 2021 Dec 9;184(25):6211. 

Maya Lopez-Ichikawa (Student)
"The Paradoxical Role of IL-10 in anti-tumor immunity"
Hanna, B.S., et al. Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity. Immunity 54.12 (2021): 2825-2841.
Coaches: Matt Spitzer, PhD & Cliff Lowell, MD, PhD

February 17, 2022

Laine Goudy (Student)
"A new role for Roquin in anti-tumor immunity"
Zhao H, Liu Y, Wang L, Jin G, Zhao X, Xu J, et al. Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Cell Reports. 2021 Dec;37(10):110083.
Coaches: Luke Gilbert, PhD & Justin Eyquem, PhD

Rhea Misra (Student)
"No time to die: Anti-aging benefits of intermittent Time Restricted Feeding are due to circadian autophagy"
Ulgherait, M., Midoun, A.M., Park, S.J. et al. Circadian autophagy drives iTRF-mediated longevity. Nature 598, 353–358 (2021). 
Coaches: Qili Liu, PhD & Leanne Jones, PhD

February 24, 2022

Cuyler Luck (Student)
"Go to sleep! Inducing dormancy to suppress metastasis"
Khalil, BD et al. "An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy." Journal of Experimental Medicine, 2021
Coaches: Rushika Perera, PhD & Jeff Bush, PhD

Kyle Jacobs (Student)
"It takes guts: using engineered hydrogels to model intestinal crypt and villi morphogenesis"
Gjorevski, N., Nikolaev, M., Brown, T. E., Mitrofanova, O., Brandenberg, N., DelRio, F. W., Yavitt, F. M., Liberali, P., Anseth, K. S., & Lutolf, M. P. (2022). Tissue geometry drives deterministic organoid patterning. Science, 375(6576). 
Coaches: Matt Kutys, PhD & Todd Nystul, PhD

March 3, 2022

Owen Jiang (Student)
"Friends or enemies? Distinct metabolic programs dictate pro- or anti-tumor function of gamma delta T cells"
Lopes, N., McIntyre, C., Martin, S. et al. Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments. Nat Immunol 22, 179–192 (2021).
Coaches: Emily Goldberg, PhD & Sagar Bapat, MD, PhD

Juliana Sucharov Costa (Student)
"Stranger Danger: the potential role of Th17 cells in Lewy body dementia"
Gate D, Tapp E, Leventhal O, et al. CD4+ T cells contribute to neurodegeneration in Lewy body dementia. Science. 2021;374(6569):868-874. doi:10.1126/science.abf7266
Coaches: Michael Waterfield, MD, PhD & Eric Huang, MD, PhD

March 10, 2022

Mary Clare Beytagh (Student)
"Tick tock: Fbl drives the developmental clock in neural stem cells"
Wu, Q., Shichino, Y., Abe, T. et al. Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells. Nat Commun 13, 470 (2022).
Coaches: David Raleigh, MD, PhD & Joanna Phillips, MD, PhD

Nav Lally (Student)
"Science is an Art: Patterned Presentation of Mitophagy in Mitochondrial Myopathy"
Mito, T., Vincent, A. E., Faitg, J., Taylor, R. W., Khan, N. A., McWilliams, T. G., & Suomalainen, A. (2022). Mosaic dysfunction of mitophagy in mitochondrial muscle disease. Cell metabolism, 34(2), 197–208.e5.
Coaches: Aparna Lakkaraju, PhD & Matthew Kutys, PhD

March 17, 2022

Min Joo Kim (Student)
"The power of E on microglial dynamics" 
Serrano-Pozo, A., Li, Z., Noori, A., Nguyen, H. N., Mezlini, A., Li, L., ... & Das, S. (2021). Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease. Nature Aging, 1(10), 919-931.
Coaches: Carlo Condello, PhD & Ryan Corces, PhD

Xian Liu (Student)
"Fuel Anti-Tumor Immune Response, Bacteria Return to the Arena"
Canale FP et al. "Metabolic modulation of tumours with engineered bacteria for immunotherapy" Nature. 2021 Oct;598(7882):662-666
Coaches: Peter Turnbaugh, PhD & Lewis Lanier, PhD

March 24, 2022

Matt Arvedson (Student)
“Do these Tregs make me look fat? Adipose Tregs are composed of distinct subsets that contribute to age and obesity related metabolic disorders”
Li, Y., Lu, Y., Lin, SH. et al. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol 22, 1175–1185 (2021).
Coaches: Sagar Bapat, MD, PhD & Ari Molofsky, MD, PhD

Caroline Whitty (Student)
“Neo Evidence for a Lung-Brain Axis”
Hosang, L. et al. The lung microbiome regulates brain autoimmunity. Nature (2022).
Coaches: Peter Turnbaugh, PhD & Ari Molofsky, MD, PhD

March 31, 2022

Nathan Ewing-Crystal (Student)
"No Pain, No Gain: Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain”
van der Vlist M, Raoof R, Willemen HLDM, et al. Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain [published online ahead of print, 2021 Dec 14]. Neuron. 2021;S0896-6273(21)00969-7. doi:10.1016/j.neuron.2021.11.020
Coaches: Ari Molofsky, MD, PhD & Cliff Lowell, MD, PhD

Kadellyn Sandoval Gutierrez (Student)
"Can you see me now?"
Jecrois ES, Zheng W, Bornhorst M, Li Y, Treisman DM, Muguyo D, Huynh S, Andrew SF, Wang Y, Jiang J, Pierce BR, Mao H, Krause MK, Friend A, Nadal-Nicolas F, Stasheff SF, Li W, Zong H, Packer RJ, and Zhu Y. "Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors" Developmental Cell. 56(20):2871-2885 (2021).
Coaches: William Weiss, MD, PhD & Joanna Phillips, MD, PhD

April 7, 2022

Kevin Ly (Student)
"Obesity Promotes CD8 (T)ysfunction in Tumors"
Dyck, L., Prendeville, H., Raverdeau, M., Wilk, M. M., Loftus, R. M., Douglas, A., McCormack, J., Moran, B., Wilkinson, M., Mills, E. L., Doughty, M., Fabre, A., Heneghan, H., LeRoux, C., Hogan, A., Chouchani, E. T., O'Shea, D., Brennan, D., & Lynch, L. (2022). Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. The Journal of experimental medicine, 219(3), e20210042.
Coaches: Mark Anderson, MD, PhD & Tiffany Scharschmidt, MD

Max Foisey (Student)
"A twist of fate, synthetic multistability in mammalian cells"
Zhu, Ronghui et al. “Synthetic multistability in mammalian cells.” Science (New York, N.Y.) vol. 375,6578 (2022): eabg9765. doi:10.1126/science.abg9765
Coaches: Kole Roybal, PhD & Bassem Al-Sady, PhD

April 14, 2022

Wendy Hung (Student)
"Making a memory (T cell), with mitochondrial metabolism"
Dudek, M., Lohr, K., Donakonda, S., Baumann, T., Lüdemann, M., Hegenbarth, S., Dübbel, L., Eberhagen, C., Michailidou, S., Yassin, A., et al. (2022). IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells. Cell Rep. 38, 110389.
Coaches: Joanna Halkias, MD & Isha Jain, PhD

Kevin Chen (Student)
"A mono-logue on B cells: Is Epstein-Barr Virus the cause of multiple sclerosis?"
Lanz, T.V., Brewer, R.C., Ho, P.P. et al. Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM. Nature (2022).
Coaches: Michael Wilson, MD & Julie Zikherman, MD

April 21, 2022

Li Wang (Student)
"Fishing for NeoTCRs: From Gene Signatures to Engineered TCR T Cell Therapy"
Lowery FJ, Krishna S, Yossef R, Parikh NB, Chatani PD, Zacharakis N, Parkhurst MR, Levin N, Sindiri S, Sachs A, Hitscherich KJ, Yu Z, Vale NR, Lu YC, Zheng Z, Jia L, Gartner JJ, Hill VK, Copeland AR, Nah SK, Masi RV, Gasmi B, Kivitz S, Paria BC, Florentin M, Kim SP, Hanada KI, Li YF, Ngo LT, Ray S, Shindorf ML, Levi ST, Shepherd R, Toy C, Parikh AY, Prickett TD, Kelly MC, Beyer R, Goff SL, Yang JC, Robbins PF, Rosenberg SA. Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers. Science. 2022 Feb 25;375(6583):877-884. doi: 10.1126/science.abl5447. Epub 2022 Feb 3. PMID: 35113651.
Coaches: Jeroen Roose, PhD & Matt Spitzer, PhD

Margaret Gadek (Student)
"AAVerse vaccine events: Lessons for future vaccine development"
Kowarz, E., Krutzke, L., Külp, M., Streb, P., Larghero, P., Reis, J., ... & Marschalek, R. (2022). Vaccine-induced COVID-19 mimicry syndrome. eLife, 11, e74974.
Coaches: Stephen Floor, PhD & Mark Ansel, PhD

April 28, 2022

Julianne Riggs (Student)
"Can an(ti)ybody bind this tumor?"
Tumor-reactive antibodies evolve from non-binding and autoreactive precursors"
Mazor RD, Nathan N, Gilboa A, Stoler-Barak L, Moss L, Solomonov I, Hanuna A, Divinsky Y, Shmueli MD, Hezroni H, Zaretsky I, Mor M, Golani O, Sabah G, Jakobson-Setton A, Yanichkin N, Feinmesser M, Tsoref D, Salman L, Yeoshoua E, Peretz E, Erlich I, Cohen NM, Gershoni JM, Freund N, Merbl Y, Yaari G, Eitan R, Sagi I, Shulman Z. Tumor-reactive antibodies evolve from non-binding and autoreactive precursors. Cell. 2022 Mar 31;185(7):1208-1222.e21. doi: 10.1016/j.cell.2022.02.012. Epub 2022 Mar 18. PMID: 35305314.
Coaches: Julie Zikherman, MD & Tiffany Scharschmidt, MD

Zack Mullin-Bernstein (Student)
"Everything in Moderation: Combating Aging via Long-Term Partial Reprograming"
Browder, K. C. et al. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nature Aging 1–11 (2022)
Coaches: Barbara Panning, PhD & Hao Li, PhD

May 5, 2022

Letitia Yang (Student)
"Defining your identity - the T follicular helper cell's journey in the germinal center"
Yeh, C.-H., Finney, J., Okada, T., Kurosaki, T., & Kelsoe, G. (2022). Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells. Immunity, 55(2).
Coaches: Julie Zikherman, MD & Tiffany Scharschmidt, MD 

Kaylee Wedderburn-Pugh (Student)
“Bears, Beets, Battlestar Galactica?: working to define the BBB, through the lens of pericyte-to-endothelial signaling”
Ayloo, S., Lazo, C. G., Sun, S., Zhang, W., Cui, B., & Gu, C. (2022). Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier. Neuron, S0896-6273(22)00184-2. Advance online publication.
Coaches: Andrew Yang, PhD & Betsy Crouch, MD, PhD

May 12, 2022

Lexi Schneider (Student)
"Micro(glia) or Macro(phages)? The Economics of Brain Immunity"
Sailor, K. A. et al. Hematopoietic stem cell transplantation chemotherapy causes microglia senescence and peripheral macrophage engraftment in the brain. Nat Med 28, 517–527 (2022).
Coaches: Andrew Yang, PhD & Ari Molofsky, MD, PhD

Charlotte Wang (Student)
"CD8+ T cells KIR+bing CD4+ T cells: 
KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19"
Li, Jing et al. “KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19.” Science (New York, N.Y.), eabi9591. 8 Mar. 2022, doi:10.1126/science.abi9591
Coaches: Rachel Rutishauser, MD, PhD & Qizhi Tang, PhD

May 19, 2022

Tori Tran (Student)
"The CAMPaign to eRAdicate Acne: A new role for preadipocytes in C. acnes infection"
O'Neill AM, Liggins MC, Seidman JS, et al. Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne. Sci Transl Med. 2022;14(632):eabh1478. doi:10.1126/scitranslmed.abh1478
Coaches: Tiffany Scharschmidt, MD & Roberto Ricardo-Gonzales, MD, PhD

Rita Loudermilk (Student)
"DUBing over biology: Engineering deubiquitinases for targeted protein stabilization."
Henning, N.J., Boike, L., Spradlin, J.N. et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol 18, 412–421 (2022).
Coaches: Jim Wells, PhD & Seth Shipman, PhD

May 26, 2022

Kyla Foster (Student)
"Space, The Final Frontier: Developing Spatial Functional Genomic Tools to Investigate the Tumor Microenvironment"
Dhainaut M, Rose SA, Akturk G, Wroblewska A, Nielsen SR, Park ES, Buckup M, Roudko V, Pia L, Sweeney R, Le Berichel J, Wilk CM, Bektesevic A, Lee BH, Bhardwaj N, Rahman AH, Baccarini A, Gnjatic S, Pe'er D, Merad M, Brown BD. Spatial CRISPR genomics identifies regulators of the tumor microenvironment. Cell. 2022 Mar 31;185(7):1223-1239.e20. doi: 10.1016/j.cell.2022.02.015. Epub 2022 Mar 14. PMID: 35290801; PMCID: PMC8992964.
Coaches: David Raleigh, MD, PhD & Jay Gardner, MD, PhD

Isabelle Young (Student)
"Targeting MAPK4 sensitizes triple-negative breast cancer to PI3K inhibition"
Wang, W., Han, D., Cai, Q. et al. MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade. Nat Commun 13, 245 (2022). 
Coaches: Mary Helen Barcellos-Hoff, PhD & Valerie Weaver, PhD

June 2, 2022

Max Pass (Student)
"You can trust the locals: FOLR2+ tissue resident macrophages associate with anti-tumor immunity"
Nalio Ramos, R. et al. Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer. Cell 185, 1189-1207.e25 (2022).

Coaches: Max Krummel, PhD and Jeroen Roose, PhD

Jingwen Ding (Student)
"Endogenous cell barcodes to reveal patterns of human brain development"
Breuss, M.W., Yang, X., Schlachetzki, J.C.M. et al. Somatic mosaicism reveals clonal distributions of neocortical development. Nature (2022).

Coaches: Daniel Lim, MD, PhD & Mercedes Paredes, MD, PhD

June 9, 2022

Evan Semenza (Student)
"Don't forget to write it down: uncovering learning-associated transcriptional programs in the cerebellum"
X. Chen, Y. Du, G. J. Broussard et al., Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning. Nature 605(7911):722-727 (2022). 
Coaches: Daniel Lim, MD, PhD & Tomasz Nowakowski, PhD

William Xie (Student)
"Ligand-receptor screens: The unreLENTIng pursuit of identifying partners"
Dobson, C.S., Reich, A.N., Gaglione, S. et al. Antigen identification and high-throughput interaction mapping by reprogramming viral entry. Nat Methods 19, 449–460 (2022).
Coaches: Andrew Yang, PhD & Rachel Rutishauser, MD, PhD