Tammy T. Chang, MD, PhD

Associate Professor
Surgery
+1 415 476-6069
Research Description: 

Tissue engineering and regeneration are the next evolutionary step in surgical practice. Today, surgeons resect, reconstruct, and transplant to treat a diverse array of diseases. In the near future, our armamentarium will increase to include using our surgical skills to induce tissue regeneration in situ or to implant ex vivo engineered organs. Accelerating advances in biotechnology, stem cell biology, and minimally invasive surgery are ripe for convergence, which will lead to the creation of novel surgical treatments to replace diseased or dysfunctional tissues. Our lab's goal is to make significant contributions to bringing these regenerative surgical therapies from the lab into the operating room.

In order to translate regenerative surgery from concept to therapeutic reality, our lab focuses on a complex and vital solid organ, the liver, for several reasons. First, there is great clinical need to develop alternative therapies for end stage liver disease, which is currently treated by liver transplantation and severely limited by the shortage of donor organs. Second, the liver has enormous innate capacity to regenerate in response to injury and metabolic demand, a feature that can be exploited to facilitate development of regenerative surgical approaches. Finally, building a solid organ such as the liver ex vivo remains the most challenging goal in tissue engineering and a problem of sufficient difficulty that is worthy of intense focus.

Our lab has 3 major areas of investigation aimed at advancing the field of liver tissue engineering:

1) Understanding the role of the physical environment and mechano-signal transduction in regulating hepatocyte function in healthy and diseased liver.
2) Elucidating the importance of dimensionality in promoting the generation of highly-functional human stem cell-derived liver organoids.
3) Developing surgical strategies for efficient orthotopic engraftment of hepatocytes and hepatic organoids into the liver.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Understanding the basic biology and realizing applicable strategies to enable liver tissue engineering for the treatment of end-stage liver disease.

Websites

Featured Publications: 

Normal and fibrotic liver parenchyma respond differently to irreversible electroporation.

HPB : the official journal of the International Hepato Pancreato Biliary Association

Lyu C, Lopez-Ichikawa M, Rubinsky B, Chang TT

Direct orthotopic implantation of hepatic organoids.

The Journal of surgical research

Zhou VX, Lolas M, Chang TT

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.

Hepatology (Baltimore, Md.)

Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT