Vincent Auyeung, MD

Asst Professor In Residence
Research Description: 

My lab studies how cellular stress responses in the lung epithelium regulate lung epithelial plasticity and differentiation across lung diseases from asthma to pulmomary fibrosis. We have a special interest in endoplasmic reticulum stress (ER stress) and the unfolded protein response. We use a combination of mouse genetics, advanced tissue culture approaches, and novel chemical biology tools.

Our active projects include:
1. Cell and molecular biology of Regulated IRE1α-Mediated Decay (RIDD) in epithelial fate transitions
2. Fate and function of epithelial transitional states in pulmonary fibrosis
3. Regulation of goblet cell metaplasia in asthma and other muco-obstructive diseases

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Stress signaling and epithelial plasticity in lung disease

BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology

Jourdan Le Saux C, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.

bioRxiv : the preprint server for biology

Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR

ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.

Nature chemical biology

Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ

Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

American journal of respiratory and critical care medicine

Auyeung VC, Sheppard D