Vincent Auyeung, MD

Asst Professor In Residence

Primary Thematic Area

Developmental & Stem Cell Biology

M_MED-CORE-PULM

Secondary Thematic Area

Tissue / Organ Biology & Endocrinology

Research Summary

Stress signaling and epithelial plasticity in lung disease

[email protected]

My lab studies how cellular stress responses in the lung epithelium regulate lung epithelial plasticity and differentiation across lung diseases from asthma to pulmomary fibrosis. We have a special interest in endoplasmic reticulum stress (ER stress) and the unfolded protein response. We use a combination of mouse genetics, advanced tissue culture approaches, and novel chemical biology tools.

Our active projects include:
1. Cell and molecular biology of Regulated IRE1α-Mediated Decay (RIDD) in epithelial fate transitions
2. Fate and function of epithelial transitional states in pulmonary fibrosis
3. Regulation of goblet cell metaplasia in asthma and other muco-obstructive diseases

Publications

Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis.

The Journal of clinical investigation

Yadav P, Gómez Ortega J, Dabral P, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang JT, Tsukui T, Molina CJ, Auyeung VC, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Tamaki SJ, Bivona TG, Abate AR, Wagner A, Pillai SK, Wolters PJ, Tharp KM, Bhattacharya M

Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification.

eLife

Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.

bioRxiv : the preprint server for biology

Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D

BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology

Jourdan Le Saux C, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR

ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.

Nature chemical biology

Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ

Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

American journal of respiratory and critical care medicine

Auyeung VC, Sheppard D

Management and Outcomes of Critically-III Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series.

medRxiv : the preprint server for health sciences

Vanderburg S, Alipanah N, Crowder R, Yoon C, Wang R, Thakur N, Slown K, Shete PB, Rofael M, Metcalfe JZ, Merrifield C, Marquez C, Malcolm K, Lipnick M, Jain V, Gomez A, Burns G, Brown LB, Berger C, Auyeung V, Cattamanchi A, Hendrickson CM

Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

Molecular therapy : the journal of the American Society of Gene Therapy

An DS, Qin FX, Auyeung VC, Mao SH, Kung SK, Baltimore D, Chen IS

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site.

Proceedings of the National Academy of Sciences of the United States of America

Dahan DS, Dibas MI, Petersson EJ, Auyeung VC, Chanda B, Bezanilla F, Dougherty DA, Lester HA

Publications

Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis.

Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification.

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.

BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis.

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.

ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.

Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

Management and Outcomes of Critically-III Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series.

Small Molecules to Improve ER Proteostasis in Disease.

Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung.

Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing.

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.

Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site.