Virology & Microbial Pathogenesis

Faculty in Virology and Microbial Pathogenesis are intrigued by how microbes manipulate their multi-cellular hosts to cause disease. The resultant research programs provide an unprecedented opportunity to influence global health. World-wide, infectious diseases are the leading cause of death, with simple diarrheal illness, malaria, and TB leading the pack. These and other infectious diseases, including AIDS, are a major impediment to economic advancement in the third world. The identification of new pathogens, the re-emergence of old pathogens, and the increasing incidence of antibiotic resistance reflect the globalization of humanity and microbes. New as well as old pathogens can rapidly move great distances and establish footholds in new niches. Strategies for the prevention, treatment, and control of infectious diseases require fundamental bench research that takes advantages of rapid advances in genomics, proteomics, cell biology, and immunology. Our faculty are dedicated to the investigation of microbial biology and host-pathogen interactions.

 

UCSF has developed world-class research programs in Infectious Disease. Virology and Microbial Pathogenesis forms one of 8 thematic areas of graduate study in the BMS program. Faculty members affiliated with this thematic area of BMS include virologists, some of whom are affiliated with the Gladstone Institute of Virology & Immunology, and researchers involved in the study of bacterial, fungal, and protozoal pathogens, who are affiliated with the Microbial Pathogenesis and Host Defense Program (MPHD). The MPHD program takes graduate students largely through BMS or the PIBS program. The Virology and Microbial Pathogenesis subdivision of BMS is truly a multi-campus and multi-disciplinary program, with investigators at Parnassus, MB, SFGH, the VA hospital, and the Gladstone Institutes of Virology at MB. The core of the program includes (i) a weekly MPHD seminar series, with invited outside researchers who are national and international leaders in the field, along with research in progress talks and journal clubs (ii) the weekly Gladstone Institutes of Virology seminar series (iii) a yearly bay area-wide symposium (Bay Area Microbial Pathogenesis Symposium), and (iv) advanced level graduate student courses in The Molecular Mechanisms of Microbial Pathogenesis (Micro and Immunology 202/Cell Bio 202) and Virology. Each of these two courses is usually offered on an alternating basis every other year in the spring quarter. In addition, selective mini-courses that study unique aspects of virology or microbial pathogenesis in detail will be offered in the spring quarter.


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Participating Faculty

Oscar Aguilar Alfaro, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
NK cells, NK receptors, and NK ligands in viral immunity and tumor immunity.

Raul Andino-Pavlovsky, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
None
Research Summary: 
Replication of RNA Viruses and Vaccine Development

Jody Baron, MD, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Innate and adaptive immunity to viral pathogens

Peter Beernink, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
My laboratory investigates molecular interactions among microbial vaccine antigens, host antibodies, and other immune system proteins.

Joseph Bondy-Denomy, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
CRISPR-Cas immunity and anti-immunity
Mentorship Development: 

4/11/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels

Jonathan Budzik, MD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
We study host and pathogen mechanisms that regulate growth of Mycobacterium tuberculosis and other mycobacteria. We are using proteomic and genetic tools to probe host responses to infection in macrophages and animal models.

Fred Chang, PhD, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
We study the regulation of cell size and shape in fission yeast S. pombe
Mentorship Development: 

4/12/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Parnassus)
4/29/19    Sharpening your Mentoring Skills (SyMS) with Sharon Milgram (Parnassus)
2/16/21   Three Truths & Three Tries: Facing & Overcoming Critical Social Justice Challenges at the Micro, Mezzo & Macro Levels

Charles Chiu, MD, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
Metagenomics-Based Technologies for Virus Detection and Discovery

Jason Cyster, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Cell Migration and Interaction Dynamics underlying Innate and Adaptive Immunity

Joanne Engel, MD, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
Bacterial host-Cell Interactions
Mentorship Development: 

11/23/20    Building Community in the UCSF MSTP

Joel Ernst, MD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
We study T cell immunity to tuberculosis (TB). In mice, we characterize mechanisms of CD4 T cell evasion in TB, and we study humans to discover mechanisms that provide protective immunity to TB that can be improved by vaccines.
Mentorship Development: 

5/2021 - Sharpening your Mentoring Skills (SyMS)

Margaret Feeney, MD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Human immunity to malaria, T cell immunity in the fetus and infant

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