Joseph Bondy-Denomy, PhD

Associate Professor
Microbiology and Immunology
+1 415 514-1381
Research Overview: 

In the Bondy-Denomy lab, we study and discover bacterial immune systems that antagonize bacteriophages (bacterial viruses). These systems include CRISPR-Cas, restriction-modification, and numerous other anti-phage defenses that are related to human innate immunity including cGAS-STING. We are very interested in how anti-phage defense works and the ways that phages fight back to survive in this ever raging arms race.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Research Summary: 
CRISPR-Cas immunity and anti-immunity
Mentorship Development: 

4/11/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels



Core defense hotspots within Pseudomonas aeruginosa are a consistent and rich source of anti-phage defense systems.

Nucleic acids research

Johnson MC, Laderman E, Huiting E, Zhang C, Davidson A, Bondy-Denomy J

F-Type Pyocins Are Diverse Noncontractile Phage Tail-Like Weapons for Killing Pseudomonas aeruginosa.

Journal of bacteriology

Saha S, Ojobor CD, Li ASC, Mackinnon E, North OI, Bondy-Denomy J, Lam JS, Ensminger AW, Maxwell KL, Davidson AR

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.

bioRxiv : the preprint server for biology

Cao X, Xiao Y, Huiting E, Cao X, Li D, Ren J, Guan L, Wang Y, Li L, Bondy-Denomy J, Feng Y

Defining the expanding mechanisms of phage-mediated activation of bacterial immunity.

Current opinion in microbiology

Huiting E, Bondy-Denomy J

Anti-CRISPR Proteins.

Journal of molecular biology

Bondy-Denomy J, Maxwell KL, Davidson AR