Joseph Bondy-Denomy, PhD

Associate Professor
Microbiology and Immunology
+1 415 514-1381
Research Description: 

In the Bondy-Denomy lab, we study CRISPR-Cas bacterial immune systems in an effort to understand their role in antagonizing viruses called bacteriophages. We are very interested in how CRISPR works and the ways that phages inhibit and evade CRISPR-Cas function.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Research Summary: 
CRISPR-Cas immunity and anti-immunity
Mentorship Development: 

4/11/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels



CRISPR inactivation by integration.

Nature microbiology

Bondy-Denomy J

Positioning Diverse Type IV Structures and Functions Within Class 1 CRISPR-Cas Systems.

Frontiers in microbiology

Taylor HN, Laderman E, Armbrust M, Hallmark T, Keiser D, Bondy-Denomy J, Jackson RN

Mobile element warfare via CRISPR and anti-CRISPR in Pseudomonas aeruginosa.

Nucleic acids research

León LM, Park AE, Borges AL, Zhang JY, Bondy-Denomy J