Joseph Bondy-Denomy, PhD

Associate Professor
Primary Thematic Area
Virology & Microbial Pathogenesis
M_Microbiology and Immunology
Secondary Thematic Area
Immunology
Research Summary
CRISPR-Cas immunity and anti-immunity
Mentorship Development

4/2019 - Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/2021 - Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels
6/2022 - Career Conversations
11/2022 - Faculty Development Program: Supervising People Who Aren't You: Mentoring/Managing Different Work Styles

[email protected]
+1 415 514-1381

In the Bondy-Denomy lab, we study and discover bacterial immune systems that antagonize bacteriophages (bacterial viruses). These systems include CRISPR-Cas, restriction-modification, and numerous other anti-phage defenses that are related to human innate immunity including cGAS-STING. We are very interested in how anti-phage defense works and the ways that phages fight back to survive in this ever raging arms race.

Websites
Bondy-Denomy Lab

Publications

Chemical inhibition of a bacterial immune system 1.

bioRxiv : the preprint server for biology

Zang Z, Duncan OK, Sabonis D, Shi Y, Miraj G, Fedorova I, Le S, Deng J, Zhu Y, Cai Y, Zhang C, Arya G, Duerkop BA, Liang H, Bondy-Denomy J, Ve T, Tamulaitiene G, Gerdt JP