Joseph Bondy-Denomy, PhD

Associate Professor
Microbiology and Immunology
+1 415 514-1381
Research Overview: 

In the Bondy-Denomy lab, we study and discover bacterial immune systems that antagonize bacteriophages (bacterial viruses). These systems include CRISPR-Cas, restriction-modification, and numerous other anti-phage defenses that are related to human innate immunity including cGAS-STING. We are very interested in how anti-phage defense works and the ways that phages fight back to survive in this ever raging arms race.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
CRISPR-Cas immunity and anti-immunity
Mentorship Development: 

4/11/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels

Websites

Publications: 

CRISPR-Cas12a targeting of ssDNA plays no detectable role in immunity.

Nucleic acids research

Marino ND, Pinilla-Redondo R, Bondy-Denomy J

Lack of Cas13a inhibition by anti-CRISPR proteins from Leptotrichia prophages.

Molecular cell

Johnson MC, Hille LT, Kleinstiver BP, Meeske AJ, Bondy-Denomy J

A single bacterial enzyme i(NHI)bits phage DNA replication.

Cell host & microbe

Huiting E, Bondy-Denomy J

Distinct Subcellular Localization of a Type I CRISPR Complex and the Cas3 Nuclease in Bacteria.

Journal of bacteriology

Govindarajan S, Borges A, Karambelkar S, Bondy-Denomy J

Genetic Manipulation of a CAST of Characters in a Microbial Community.

The CRISPR journal

Mozumdar D, Csörgo B, Bondy-Denomy J