Joseph Bondy-Denomy, PhD

Assistant Professor
Microbiology and Immunology
+1 415 514-1381
Research Description: 

In the Bondy-Denomy lab, we study CRISPR-Cas bacterial immune systems in an effort to understand their role in antagonizing viruses called bacteriophages. We are very interested in how CRISPR works and the ways that phages inhibit and evade CRISPR-Cas function.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Research Summary: 
CRISPR-Cas immunity and anti-immunity



Mobile element warfare via CRISPR and anti-CRISPR in Pseudomonas aeruginosa.

Nucleic acids research

León LM, Park AE, Borges AL, Zhang JY, Bondy-Denomy J

A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.

Molecular cell

Shah M, Taylor VL, Bona D, Tsao Y, Stanley SY, Pimentel-Elardo SM, McCallum M, Bondy-Denomy J, Howell PL, Nodwell JR, Davidson AR, Moraes TF, Maxwell KL

Intracellular Organization by Jumbo Bacteriophages.

Journal of bacteriology

Guan J, Bondy-Denomy J

Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements.

Nature communications

Pinilla-Redondo R, Shehreen S, Marino ND, Fagerlund RD, Brown CM, Sørensen SJ, Fineran PC, Bondy-Denomy J