Joseph Bondy-Denomy, PhD

Assistant Professor
Microbiology and Immunology
+1 415 514-1381
Research Description: 

In the Bondy-Denomy lab, we study CRISPR-Cas bacterial immune systems in an effort to understand their role in antagonizing viruses called bacteriophages. We are very interested in how CRISPR works and the ways that phages inhibit and evade CRISPR-Cas function.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Research Summary: 
CRISPR-Cas immunity and anti-immunity



Protein Inhibitors of CRISPR-Cas9.

ACS chemical biology

Bondy-Denomy J

How bacteria control the CRISPR-Cas arsenal.

Current opinion in microbiology

Leon LM, Mendoza SD, Bondy-Denomy J

Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation.

Nature microbiology

Harvey H, Bondy-Denomy J, Marquis H, Sztanko KM, Davidson AR, Burrows LL

The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs.

Annual review of virology

Borges AL, Davidson AR, Bondy-Denomy J

Disabling Cas9 by an anti-CRISPR DNA mimic.

Science advances

Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA