Joseph Bondy-Denomy, PhD

Associate Professor
Microbiology and Immunology
+1 415 514-1381
Research Description: 

In the Bondy-Denomy lab, we study CRISPR-Cas bacterial immune systems in an effort to understand their role in antagonizing viruses called bacteriophages. We are very interested in how CRISPR works and the ways that phages inhibit and evade CRISPR-Cas function.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Research Summary: 
CRISPR-Cas immunity and anti-immunity
Mentorship Development: 

4/11/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels



CRISPR-Cas12a targeting of ssDNA plays no detectable role in immunity.

Nucleic acids research

Marino ND, Pinilla-Redondo R, Bondy-Denomy J

Lack of Cas13a inhibition by anti-CRISPR proteins from Leptotrichia prophages.

Molecular cell

Johnson MC, Hille LT, Kleinstiver BP, Meeske AJ, Bondy-Denomy J

A single bacterial enzyme i(NHI)bits phage DNA replication.

Cell host & microbe

Huiting E, Bondy-Denomy J

Distinct Subcellular Localization of a Type I CRISPR Complex and the Cas3 Nuclease in Bacteria.

Journal of bacteriology

Govindarajan S, Borges A, Karambelkar S, Bondy-Denomy J

Genetic Manipulation of a CAST of Characters in a Microbial Community.

The CRISPR journal

Mozumdar D, Csörgo B, Bondy-Denomy J