Joseph Bondy-Denomy, PhD

Associate Professor

Microbiology and Immunology

+1 415 514-1381

Research Overview:

In the Bondy-Denomy lab, we study and discover bacterial immune systems that antagonize bacteriophages (bacterial viruses). These systems include CRISPR-Cas, restriction-modification, and numerous other anti-phage defenses that are related to human innate immunity including cGAS-STING. We are very interested in how anti-phage defense works and the ways that phages fight back to survive in this ever raging arms race.

Primary Thematic Area:

Virology & Microbial Pathogenesis

Secondary Thematic Area:

Immunology

Research Summary:

CRISPR-Cas immunity and anti-immunity

Mentorship Development:

4/11/19 Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/16/21 Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels

Websites

Bondy-Denomy Lab

Publications:

Joseph Bondy-Denomy, PhD

Websites

Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense.

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.

Cas9 degradation in human cells using phage anti-CRISPR proteins.

Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile.

Single phage proteins sequester TIR- and cGAS-generated signaling molecules.

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Joseph Bondy-Denomy, PhD

Websites

Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense.

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.

Cas9 degradation in human cells using phage anti-CRISPR proteins.

Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile.

Single phage proteins sequester TIR- and cGAS-generated signaling molecules.