Joseph Bondy-Denomy, PhD

Assistant Professor
Microbiology and Immunology
+1 415 514-1381
Research Description: 

In the Bondy-Denomy lab, we study CRISPR-Cas bacterial immune systems in an effort to understand their role in antagonizing viruses called bacteriophages. We are very interested in how CRISPR works and the ways that phages inhibit and evade CRISPR-Cas function.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Research Summary: 
CRISPR-Cas immunity and anti-immunity



A compact Cascade-Cas3 system for targeted genome engineering.

Nature methods

Csörgo B, León LM, Chau-Ly IJ, Vasquez-Rifo A, Berry JD, Mahendra C, Crawford ED, Lewis JD, Bondy-Denomy J

Intracellular Organization by Jumbo Bacteriophages.

Journal of bacteriology

Guan J, Bondy-Denomy J

Machine-learning approach expands the repertoire of anti-CRISPR protein families.

Nature communications

Gussow AB, Park AE, Borges AL, Shmakov SA, Makarova KS, Wolf YI, Bondy-Denomy J, Koonin EV

Structures and Strategies of Anti-CRISPR-Mediated Immune Suppression.

Annual review of microbiology

Wiegand T, Karambelkar S, Bondy-Denomy J, Wiedenheft B

Author Correction: Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer.

Nature microbiology

Mahendra C, Christie KA, Osuna BA, Pinilla-Redondo R, Kleinstiver BP, Bondy-Denomy J