Fred Chang, PhD, MD

Professor
Department of Cell & Tissue Biology
+1 415 476-8922
Research Description: 

The Chang Lab studies fundamental questions concerning spatial organization within a single cell: How are cell shape and size determined? How do cells sense their own size, or their shape? How do molecular dynamics and cell mechanics contribute to determine the growth, size and shape of cells? To address these questions, we study primarily the fission yeast Schizosaccharomyces pombe. These are rod-shaped eukaryotic cells that display a highly uniform size and morphology. Many of our studies use live cell imaging and image analyses to develop quantitative models. Current projects include: regulation of cell size and growth, cytoplasmic density and turgor pressure, cell wall assembly, cytokinesis, and microtubule regulation. We use interdisciplinary approaches, combining the expertise and perspectives of cell biologists, geneticists, physicists, engineers and modelers.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
We study the regulation of cell size and shape in fission yeast S. pombe

Websites

Publications: 

Decoupling of Rates of Protein Synthesis from Cell Expansion Leads to Supergrowth.

Cell systems

Knapp BD, Odermatt P, Rojas ER, Cheng W, He X, Huang KC, Chang F

Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.

Molecular biology of the cell

Zhurinsky J, Salas-Pino S, Iglesias-Romero AB, Torres-Mendez A, Knapp B, Flor-Parra I, Wang J, Bao K, Jia S, Chang F, Daga RR

Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast.

Current biology : CB

Facchetti G, Knapp B, Flor-Parra I, Chang F, Howard M

The outer membrane is an essential load-bearing element in Gram-negative bacteria.

Nature

Rojas ER, Billings G, Odermatt PD, Auer GK, Zhu L, Miguel A, Chang F, Weibel DB, Theriot JA, Huang KC