Jonathan Budzik, MD

Asst Professor In Residence
Medicine
[email protected]
+1 415 476-7147
Research Description: 

My research is focused on the study of immune responses to pathogens including Mycobacterium tuberculosis. By understanding the mechanisms that enable pathogens to grow within our immune cells, we hope to enable the development of new therapies to treat infectious diseases.

As a pulmonary and critical care physician, I provide patient care in the intensive care units, the adult cystic fibrosis clinic, and the bronchiectasis clinic. I am an Associate Director of the UCSF Adult Cystic Fibrosis program.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
We study host and pathogen mechanisms that regulate growth of Mycobacterium tuberculosis and other mycobacteria. We are using proteomic and genetic tools to probe host responses to infection in macrophages and animal models.
Publications: 

Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages.

bioRxiv : the preprint server for biology

Chin J, Abeydeera N, Repasy T, Rivera-Lugo R, Mitchell G, Nguyen VQ, Zheng W, Richards A, Swaney DL, Krogan NJ, Ernst JD, Cox JS, Budzik JM

Author Correction: Autophagy restricts Mycobacterium tuberculosis during acute infection in mice.

Nature microbiology

Golovkine GR, Roberts AW, Morrison HM, Rivera-Lugo R, McCall RM, Nilsson H, Garelis NE, Repasy T, Cronce M, Budzik J, Van Dis E, Popov LM, Mitchell G, Zalpuri R, Jorgens D, Cox JS

History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.

PLoS genetics

Nieto-Caballero VE, Reijneveld JF, Ruvalcaba A, Innocenzi G, Abeydeera N, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, León SR, Calderon RI, Lecca L, Budzik JM, Murray M, Van Rhijn I, Raychaudhuri S, Moody DB, Suliman S, Gutierrez-Arcelus M

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.

PLoS pathogens

Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.

Research square

Zheng W, Chang IC, Limberis J, Budzik J, Zha BS, Howard Z, Chen L, Ernst J