Jonathan Budzik, MD

Assistant Prof. In Residence
Medicine
[email protected]
+1 415 476-7147
Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
We study host and pathogen mechanisms that regulate growth of Mycobacterium tuberculosis and other mycobacteria. We are using proteomic and genetic tools to probe host responses to infection in macrophages and animal models.
Publications: 

Autophagy restricts Mycobacterium tuberculosis during acute infection in mice.

Nature microbiology

Golovkine GR, Roberts AW, Morrison HM, Rivera-Lugo R, McCall RM, Nilsson H, Garelis NE, Repasy T, Cronce M, Budzik J, Van Dis E, Popov LM, Mitchell G, Zalpuri R, Jorgens D, Cox JS

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during persistent infection.

bioRxiv : the preprint server for biology

Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Ernst JD

Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms.

mBio

Mitchell G, Silvis MR, Talkington KC, Budzik JM, Dodd CE, Paluba JM, Oki EA, Trotta KL, Licht DJ, Jimenez-Morales D, Chou S, Savage PB, Gross CA, Marletta MA, Cox JS

Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.

Cell reports

Hiatt J, Cavero DA, McGregor MJ, Zheng W, Budzik JM, Roth TL, Haas KM, Wu D, Rathore U, Meyer-Franke A, Bouzidi MS, Shifrut E, Lee Y, Kumar VE, Dang EV, Gordon DE, Wojcechowskyj JA, Hultquist JF, Fontaine KA, Pillai SK, Cox JS, Ernst JD, Krogan NJ, Marson A

Antibiotic adverse reactions in adult cystic fibrosis patients.

The journal of allergy and clinical immunology. In practice

Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM