
Asst Professor In Residence
Primary Thematic Area
M_MED-CORE-PULM
Secondary Thematic Area
Research Summary
We study host and pathogen mechanisms that regulate growth of Mycobacterium tuberculosis and other mycobacteria. We are using proteomic and genetic tools to probe host responses to infection in macrophages and animal models.
+1 415 476-7147
My research is focused on the study of immune responses to pathogens including Mycobacterium tuberculosis. By understanding the mechanisms that enable pathogens to grow within our immune cells, we hope to enable the development of new therapies to treat infectious diseases.
As a pulmonary and critical care physician, I provide patient care in the intensive care units, the adult cystic fibrosis clinic, and the bronchiectasis clinic. I am an Associate Director of the UCSF Adult Cystic Fibrosis program.
Publications
An unusual genetic switch controls Mycobacterium avium pathogenesis, antibiotic resistance and colony morphology.
bioRxiv : the preprint server for biology
Hyaluronan Ameliorates Viral Pneumonia in Mice and Humans by Inhibiting E2F1 Transcription Factor.
American journal of respiratory cell and molecular biology
Synthesis, structural characterization, and antimicrobial activity of Zn(cloxyquin)2: towards harnessing zinc intoxication and immune response restoration to combat Staphylococcus aureus and Mycobacterium tuberculosis.
Dalton transactions (Cambridge, England : 2003)
Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages.
bioRxiv : the preprint server for biology
Author Correction: Autophagy restricts Mycobacterium tuberculosis during acute infection in mice.
Nature microbiology
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.
PLoS genetics
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
PLoS pathogens
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
Research square
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during persistent infection.
bioRxiv : the preprint server for biology
Autophagy restricts Mycobacterium tuberculosis during acute infection in mice.
Nature microbiology
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
Cell reports
Antibiotic adverse reactions in adult cystic fibrosis patients.
The journal of allergy and clinical immunology. In practice
Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereus.
Molecular microbiology
Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient.
Surgical infections
Two capsular polysaccharides enable Bacillus cereus G9241 to cause anthrax-like disease.
Molecular microbiology
Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds.
Nature reviews. Microbiology
Intramolecular amide bonds stabilize pili on the surface of bacilli.
Proceedings of the National Academy of Sciences of the United States of America
Sortase D forms the covalent bond that links BcpB to the tip of Bacillus cereus pili.
The Journal of biological chemistry
Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin.
Molecular microbiology
Cell wall anchor structure of BcpA pili in Bacillus anthracis.
The Journal of biological chemistry
Sortases make pili from three ingredients.
Proceedings of the National Academy of Sciences of the United States of America
Amide bonds assemble pili on the surface of bacilli.
Proceedings of the National Academy of Sciences of the United States of America
Assembly of pili on the surface of Bacillus cereus vegetative cells.
Molecular microbiology
Pili prove pertinent to enterococcal endocarditis.
The Journal of clinical investigation
Isolation and characterization of a generalized transducing phage for Pseudomonas aeruginosa strains PAO1 and PA14.
Journal of bacteriology
The role of bacterial biofilms in ocular infections.
DNA and cell biology