Virology & Microbial Pathogenesis

Faculty in Virology and Microbial Pathogenesis are intrigued by how microbes manipulate their multi-cellular hosts to cause disease. The resultant research programs provide an unprecedented opportunity to influence global health. World-wide, infectious diseases are the leading cause of death, with simple diarrheal illness, malaria, and TB leading the pack. These and other infectious diseases, including AIDS, are a major impediment to economic advancement in the third world. The identification of new pathogens, the re-emergence of old pathogens, and the increasing incidence of antibiotic resistance reflect the globalization of humanity and microbes. New as well as old pathogens can rapidly move great distances and establish footholds in new niches. Strategies for the prevention, treatment, and control of infectious diseases require fundamental bench research that takes advantages of rapid advances in genomics, proteomics, cell biology, and immunology. Our faculty are dedicated to the investigation of microbial biology and host-pathogen interactions.

 

UCSF has developed world-class research programs in Infectious Disease. Virology and Microbial Pathogenesis forms one of 8 thematic areas of graduate study in the BMS program. Faculty members affiliated with this thematic area of BMS include virologists, some of whom are affiliated with the Gladstone Institute of Virology & Immunology, and researchers involved in the study of bacterial, fungal, and protozoal pathogens, who are affiliated with the Microbial Pathogenesis and Host Defense Program (MPHD). The MPHD program takes graduate students largely through BMS or the PIBS program. The Virology and Microbial Pathogenesis subdivision of BMS is truly a multi-campus and multi-disciplinary program, with investigators at Parnassus, MB, SFGH, the VA hospital, and the Gladstone Institutes of Virology at MB. The core of the program includes (i) a weekly MPHD seminar series, with invited outside researchers who are national and international leaders in the field, along with research in progress talks and journal clubs (ii) the weekly Gladstone Institutes of Virology seminar series (iii) a yearly bay area-wide symposium (Bay Area Microbial Pathogenesis Symposium), and (iv) advanced level graduate student courses in The Molecular Mechanisms of Microbial Pathogenesis (Micro and Immunology 202/Cell Bio 202) and Virology. Each of these two courses is usually offered on an alternating basis every other year in the spring quarter. In addition, selective mini-courses that study unique aspects of virology or microbial pathogenesis in detail will be offered in the spring quarter.


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Participating Faculty

Suzanne Noble, MD, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
The Biology of Candida albicans, a Unique Fungal Commensal-Pathogen of Humans

Melanie Ott, MD, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
Molecular Pathogenesis of HIV and Hepatitis C Virus Infections

Matija Peterlin, MD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Transcriptional regulation of HIV, immune response genes and AIRE. HIV latency and reactivation. CTD kinases that regulate transcription elongation and co-transcriptional processing as well as growth, proliferation and differentiation of cells.

Katie Pollard, PhD

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Statistical and Computational Methods for the Analysis of Massive Genomic Datasets

Nadia Roan, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
The Roan Lab is interested in studying how cells and secretions of the mucosa, particularly the genital mucosa, can affect immunity, infection by HIV, and reproductive health.

Oren Rosenberg, MD, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
Laboratory of Molecular Pathogenesis

Philip Rosenthal, MD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
We study malaria, including: a) translational studies of drug efficacy and resistance; b) drug discovery and mechanisms of action of novel compounds; and c) basic biology of malaria parasites.

Shomyseh Sanjabi, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Mucosal Antiviral Immunity

Tiffany Scharschmidt, MD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Immune mechanisms that support host-commensal symbiosis

Anita Sil, MD, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
Regulation of cell shape and virulence by temperature in the fungal pathogen Histoplasma capsulatum

Paul Sullam, MD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
None
Research Summary: 
Pathogenetic mechanisms of Gram-positive pathogens

Peter Turnbaugh, PhD

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
Impact of the human gut microbiome on pharmacology and nutrition

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