Melanie Ott, MD, PhD

Senior Investigator, Gladstone Institute of Virology and Immunology
Professor
Department of Medicine
+1 415 734-4807
Research Overview: 

We study viruses of today to be prepared for the viruses of tomorrow. Currently, we focus on multiple human pathogens—the human immunodeficiency virus (HIV-1), Zika virus, the hepatitis B and C viruses (HBV and HCV), influenza A and B , SARS-CoV-2 and multiple common cold coronaviruses. We use four main technologies—human organoids, rapid quantitative diagnostics, a viral protein expression library, and transcriptomics. We deliberately apply lessons learned from one virus to others; specifically, we search for common host and viral factors that can be targeted by panviral therapeutics against respiratory viruses, define new ways to silence and cure chronic viral infections such as HIV and HBV and develop versatile, easy to reprogram CRISPR diagnostics that use mobile phones as readers. We welcome graduate students into our diverse and friendly research teams as equal partners and nurture their scientific success and personal growth.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
Molecular Pathogenesis of HIV and Hepatitis C Virus Infections

Websites

Publications: 

Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases.

Nature chemical biology

Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA

Accelerated RNA detection using tandem CRISPR nucleases.

Nature chemical biology

Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ, IGI Testing Consortium , Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA

Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.

ACS infectious diseases

Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.

Scientific reports

Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M

SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.

bioRxiv : the preprint server for biology

Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP