Mechanisms underlying transcriptional dysregulation, DNA damage responses, inflammation and resistance. Design theranostics targeting the cancer surface proteome and define synthetic lethal interactions.
Elucidating the impact of the human gut microbiome on the treatment of autoimmune disease. Microbiology, translational studies with human samples, metagenomics, gnotobiotics, metabolomics, immunology.
Mentorship Development:
2017 - Scientific Leadership and Laboratory Management Course, UCSF
1/2022 - DEI Champion Training
10/2022 - UCSF-TRAIN-UP program (now called Inclusive Research Mentor/Manager Training)
2/2022 - Raising a Resilient Researcher (NIH-OITE)
The central theme of the Chorba Lab is to model clinically relevant phenomena in a controlled environment. The major goals are to develop new therapies, targets, and diagnostics that change paradigms in medicine. Inspired by clinical practice, we 1) develop biochemical tools and 2) tackle seemingly undruggable targets to 3) understand the mechanistic basis of cardiometabolic disease and beyond. We work at the interface of chemistry and biology, using the bidirectionality of bench-to-bedside research to expand our findings from any given disease model to the fundamental biology at play.
The Bhattacharya Laboratory studies the effect of macrophages on fibroblast activation during the fibrotic phase of tissue injury, with a focus on lung fibrosis.
We leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis.
Our team studies how chromatin receives, processes, and amplifies environmental stress signals that drive changes in cell states leading to heart disease.
