Roarke Kamber, PhD

Assistant Professor
Research Description: 

My research interests center on understanding how macrophages detect and eliminate disease-causing cells, including cancer cells, and determining why this homeostatic process fails in aging and disease. To this end, my research encompasses questions in immunology and cancer biology, and leverages a wide range of experimental approaches including genome-wide CRISPR screens, live-cell imaging, biochemical reconstitution, and animal models. We aim to systematically map the inter-cellular signaling axes between macrophages and their target cells that govern phagocytosis, with a particular focus on defining the roles of uncharacterized genes and metabolites in this process. These discovery-based efforts will allow us to understand how macrophages make the all-or-none decision to destroy another cell, to characterize pathological failure modes, and to engineer innate immune cells with enhanced therapeutic properties. The ultimate goal of my research program is to uncover fundamental biological insights that enable next-generation immunotherapies for currently untreatable diseases.

Primary Thematic Area: 
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Mechanisms of Macrophage-Mediated Cell Clearance



A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking.

bioRxiv : the preprint server for biology

Donnelly J, Kamber RA, Wisnovsky S, Roberts DS, Peltan EL, Bassik MC, Bertozzi CR

Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras.

Science (New York, N.Y.)

Ahn G, Riley NM, Kamber RA, Wisnovsky S, Moncayo von Hase S, Bassik MC, Banik SM, Bertozzi CR

Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes.

Nature chemistry

Chen Y, Craven GB, Kamber RA, Cuesta A, Zhersh S, Moroz YS, Bassik MC, Taunton J

Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.


Kamber RA, Nishiga Y, Morton B, Banuelos AM, Barkal AA, Vences-Catalán F, Gu M, Fernandez D, Seoane JA, Yao D, Liu K, Lin S, Spees K, Curtis C, Jerby-Arnon L, Weissman IL, Sage J, Bassik MC