Renuka Nayak, MD, PhD

Asst Professor in Residence
Medicine
+1 415 221-4810 ext. 22398
Research Overview: 

The Nayak Lab studies the human gut microbiome and its impact on the treatment of autoimmune and rheumatic disease. We use cutting-edge technologies, such next-generation sequencing, anaerobic microbiology, metabolomics, gnotobiotics, single-cell phenotyping, and CRISPR to investigate the molecular mechanisms by which microbes impact human health and disease. We are also a translational research lab that obtains and studies patient samples; our goal is make discoveries with strong clinical implications. 

In the Nayak Lab, you can expect to become an expert on multiple of the following skills:

  • Analysis and visualization of large datasets using programming languages such as R
  • Generation and analysis of sequencing libraries, such as metagenomics, transcriptomics and transposon-sequencing libraries
  • In vitro anaerobic microbiology
  • Analytical chemistry, including HPLC, LC-MS, MALDI-TOF and qTOF
  • Gnotobiology and mouse models of autoimmunity
  • Single cell immune profiling
  • Analysis of patient specimens from observational cohorts and interventional studies

We seek to understand the mechanisms by which gut microbes impact the treatment of autoimmune disease using cutting-edge technologies. We strive to advance precision medicine for patients with rheumatic disease.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Elucidating the impact of the human gut microbiome on the treatment of autoimmune disease. Microbiology, translational studies with human samples, metagenomics, gnotobiotics, metabolomics, immunology.
Mentorship Development: 

2017 - Scientific Leadership and Laboratory Management Course, UCSF
1/2022 - DEI Champion Training
10/2022 - UCSF-TRAIN-UP program (now called Inclusive Research Mentor/Manager Training)
2/2022 - Raising a Resilient Researcher (NIH-OITE)

Publications: 

Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wu KC, McCauley KE, Lynch SV, Nayak RR, King NJ, Patel S, Kim TY, Condra K, Fadrosh D, Nguyen D, Lin DL, Lynch K, Rogers SJ, Carter JT, Posselt AM, Stewart L, Schafer AL

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.

bioRxiv : the preprint server for biology

Alexander M, Upadhyay V, Rock R, Ramirez L, Puchalska P, Orellana D, Ang QY, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ

Simvastatin induces human gut bacterial cell surface genes.

Molecular microbiology

Escalante V, Nayak RR, Noecker C, Babdor J, Spitzer M, Deutschbauer AM, Turnbaugh PJ

Fanning the Flames of Autoimmunity: The Microbiome in Rheumatic Disease.

Arthritis & rheumatology (Hoboken, N.J.)

Nayak RR