Jonathan Chou, MD, PhD
Our research group is interested in cancer biology and translational oncology. Current research focuses on (1) understanding the molecular drivers of genitourinary cancers, including CDK12 mutations in prostate cancer; (2) investigating the mechanisms that contribute to disease progression, drug resistance and metastasis, including the role of the tumor immune microenvironment; and (3) developing novel surface-targeting therapies, including CAR T cells, bispecific immune cell engagers, antibody drug conjugates and radioimmunotherapies.
Our lab is part of the UCSF Prostate Cancer and Bladder Cancer Programs, the Division of Hematology/Oncology, and the UCSF Helen Diller Family Comprehensive Cancer Center. We utilize cancer cell biology, immunology, CRISPR screening, mouse modeling and genomic approaches, and aim to translate discoveries from the lab into the clinic.
We work collaboratively with basic scientists, radiologists, chemists, computational biologists, pathologists, urologic surgical oncologists, radiation oncologists and medical oncologists. We are excited to share our research with you!