Aparna Sundaram, MD

Assoc Professor in Residence
Medicine
+1 415 514-8363
Research Description: 

Dr. Sundaram is a biomedical engineer, physician, and scientist with an interest in airway smooth muscle biology. Her laboratory focuses on tethering pathways used by muscle to transmit force. Through a more nuanced understanding of pathways that contribute to force transmission and the influence on pro-inflammatory cytokines on regulating these pathways, Dr. Sundaram hopes to identify novel drug targets to mitigate exaggerated airway narrowing in chronic airways diseases. Her work leverages ex vivo and in vivo disease models, transgenic mouse models, and advanced microscopy to map force transmission pathways on a cellular level.

Dr. Sundaram also attends in the Moffitt-Long Intensive Care Units. She serves as the Associate Director for the Molecular Medicine Residency Program. Her primary interests in physician-scientist training are related to longitudinal mentoring, work-life integration, and supporting women and minorities in science.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Immunology
Research Summary: 
Immune regulation of ECM and force transmission pathways in airway smooth muscle

Websites

Publications: 

IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle.

Proceedings of the National Academy of Sciences of the United States of America

Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB

Integrin a2ß1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

The Journal of clinical investigation

Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB

Dual antagonists of a5ß1/ avß1 integrin for airway hyperresponsiveness.

Bioorganic & medicinal chemistry letters

Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H

G protein-regulated endocytic trafficking of adenylyl cyclase type 9.

eLife

Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M

A disease associated mutation in fibrillin-1 differentially regulates integrin mediated cell adhesion.

The Journal of biological chemistry

Del Cid JS, Isik Reed N, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB