In our lab, we use live imaging in the cochlea to visualize how calcium dysregulation and stress pathways cause hearing loss, to help us identify molecular targets for treatment.
We study signaling between neural tissues and bodily fluids, with a focus on specialized interfaces near brain ventricles to uncover their roles in health, disease, and therapeutic applications.
The central theme of the Chorba Lab is to model clinically relevant phenomena in a controlled environment. The major goals are to develop new therapies, targets, and diagnostics that change paradigms in medicine. Inspired by clinical practice, we 1) develop biochemical tools and 2) tackle seemingly undruggable targets to 3) understand the mechanistic basis of cardiometabolic disease and beyond. We work at the interface of chemistry and biology, using the bidirectionality of bench-to-bedside research to expand our findings from any given disease model to the fundamental biology at play.
The Bhattacharya Laboratory studies the effect of macrophages on fibroblast activation during the fibrotic phase of tissue injury, with a focus on lung fibrosis.
We leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis.
