Kelsey Collins, PhD

Assistant Professor In Res
Orthopaedic Surgery
Research Overview: 

In the Laboratory for Musculoskeletal Crosstalk, we leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis. Our work aims to delineate fat-cartilage signals that contribute to osteoarthritis susceptibility and pain to generate a new class of regenerative medicine-based therapies. We use in vitro and in vivo approaches, induced pluripotent stem cells, CRISPR-Cas9 genome engineering, mouse models, human tissues, and state-of-the-art multi-omic spatial approaches. As pathological fat signaling may play a role in many disease processes, we work to define the mechanisms and create therapies that have implications to aging, obesity, diabetes and other chronic diseases. We value diversity in backgrounds and experience. We believe that diversity drives creativity and innovation, and we are dedicated to fostering an inclusive ecosystem where everyone feels valued and respected. Our mission is to improve patient outcomes through exciting, collaborative and innovative approaches in Musculoskeletal Research.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
We leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis.

Websites

Publications: 

Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat-High-Sucrose Diet in a Rat Model.

Cartilage

Abughazaleh N, Boldt K, Rios JL, Mattiello SM, Collins KH, Seerattan RA, Herzog W

Post or Perish? Social Media Strategies for Disseminating Orthopedic Research.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Buettmann EG, Chlebek C, Lockard CA, Clayton SW, Lewis KJ, Collins KH

Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy.

Gels (Basel, Switzerland)

Collins KH, Pferdehirt L, Saleh LS, Savadipour A, Springer LE, Lenz KL, Thompson DM, Oswald SJ, Pham CTN, Guilak F

The role of PIEZO ion channels in the musculoskeletal system.

American journal of physiology. Cell physiology

Savadipour A, Palmer D, Ely EV, Collins KH, Garcia-Castorena JM, Harissa Z, Kim YS, Oestrich A, Qu F, Rashidi N, Guilak F

#OrthoTwitter: Relationship Between Author Twitter Utilization and Academic Impact in Orthopaedic Surgery.

Cureus

Halvorson RT, Allahabadi S, Cevallos N, Foley AJ, Collins K, Torres Espin A, Feeley BT, Pandya NK, Bailey JF