Kelsey Collins, PhD

In the Laboratory for Musculoskeletal Crosstalk, we leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis. Our work aims to delineate fat-cartilage signals that contribute to osteoarthritis susceptibility and pain to generate a new class of regenerative medicine-based therapies. We use in vitro and in vivo approaches, induced pluripotent stem cells, CRISPR-Cas9 genome engineering, mouse models, human tissues, and state-of-the-art multi-omic spatial approaches. As pathological fat signaling may play a role in many disease processes, we work to define the mechanisms and create therapies that have implications to aging, obesity, diabetes and other chronic diseases. We value diversity in backgrounds and experience. We believe that diversity drives creativity and innovation, and we are dedicated to fostering an inclusive ecosystem where everyone feels valued and respected. Our mission is to improve patient outcomes through exciting, collaborative and innovative approaches in Musculoskeletal Research.