Peter Bruno, PhD

Assistant Professor
Primary Thematic Area: 
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
We use synthetic biology and high-throughput functional genetic screens to understand antigen presentation and T-cell recognition in the context of cancer and other diseases.


Featured Publications: 

High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.

Nature biotechnology

Bruno PM, Timms RT, Abdelfattah NS, Leng Y, Lelis FJN, Wesemann DR, Yu XG, Elledge SJ

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.

Nature medicine

Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, Pritchard JR, Pommier Y, Lippard SJ, Hemann MT

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.

Proceedings of the National Academy of Sciences of the United States of America

Bruno PM, Lu M, Dennis KA, Inam H, Moore CJ, Sheehe J, Elledge SJ, Hemann MT, Pritchard JR

Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.

Proceedings of the National Academy of Sciences of the United States of America

Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT

Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity.

Journal of the American Chemical Society

Barnes JC, Bruno PM, Nguyen HV, Liao L, Liu J, Hemann MT, Johnson JA