Assistant Professor
Primary Thematic Area
M_Urology
Secondary Thematic Area
Research Summary
We use synthetic biology and high-throughput functional genetic screens to understand antigen presentation and T-cell recognition in the context of cancer and other diseases.
Mentorship Development
10-11/2023 - UCSF Inclusive Mentor/Manager Training
11/2024 - The 4 Touchstones of a High-Functioning Mentoring Relationship
Websites
Publications
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.
Nature biotechnology
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.
Nature medicine
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.
Proceedings of the National Academy of Sciences of the United States of America
Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.
Proceedings of the National Academy of Sciences of the United States of America
Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity.
Journal of the American Chemical Society