Cancer Biology & Cell Signaling

The UCSF Helen Diller Family Comprehensive Cancer Center is an interdisciplinary initiative that combines basic science, clinical research, epidemiology/cancer control, and patient care throughout the University of California, San Francisco. The Center's mission is the discovery and evolution of new ideas and information about cancer, from basic research to clinical implementation.


UCSF's long tradition of excellence in cancer research includes, notably, Nobel Prize-winning work of J. Michael Bishop and Harold Varmus, who discovered cancer-causing oncogenes. Their work opened new doors for exploring genetic mistakes that cause cancer and formed the basis for some of the most important cancer research happening today.


Basic scientific research underpins all of our efforts to design and evaluate new tools to treat cancer patients everywhere. Hence, cancer research at UCSF encompasses studies on the regulation of the eukaryotic cell division cycle, exploration of the machinery and the control of programmed cell death (apoptosis), regulation of cellular lifespan and the acquisition of cellular immortality, the control of DNA repair, the role of the immune system in cancer initiation and progression, tumor angiogenesis, cell invasion and metastasis and the design and application of mouse models of human cancer. Information of the broad range of cancer research activities can be found at the Cancer Center webpage.

 

Participating Faculty

Jeffrey Bluestone, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Regulation of T-cell activation and tolerance during autoimmune and transplantation responses

Rohit Bose, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
We study hypermutation, drug sensitization and oncogene network alterations in patients in order to improve precision medicine therapies for hormone-related and genitourinary cancers.

Andrew Brack, PhD

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling

Ben Braun, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Ras signaling in cancer stem cells

Katja Brueckner, PhD

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Hematopoiesis and cell signaling

Fred Chang, PhD, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
We study the regulation of cell size and shape in fission yeast S. pombe

Harold Chapman, MD

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Stem Cells in Lung Tissue Remodeling and Repair

James Cleaver, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
DNA Repair Mechanisms and Human Disease

Eric Collisson, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
I am a medical oncologist with a specific interest in the genomics of cancer.

Joseph Costello, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Mechanistic and Translational Cancer Research using Genomic and Epigenomic Approaches

Jayanta Debnath, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Autophagy In Cell Survival and Cancer Progression

Anthony Defranco, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Regulation of B Lymphocyte and Macrophage Function by Cell Surface Receptors

Pages