Cancer Biology & Cell Signaling

The UCSF Helen Diller Family Comprehensive Cancer Center is an interdisciplinary initiative that combines basic science, clinical research, epidemiology/cancer control, and patient care throughout the University of California, San Francisco. The Center's mission is the discovery and evolution of new ideas and information about cancer, from basic research to clinical implementation.


UCSF's long tradition of excellence in cancer research includes, notably, Nobel Prize-winning work of J. Michael Bishop and Harold Varmus, who discovered cancer-causing oncogenes. Their work opened new doors for exploring genetic mistakes that cause cancer and formed the basis for some of the most important cancer research happening today.


Basic scientific research underpins all of our efforts to design and evaluate new tools to treat cancer patients everywhere. Hence, cancer research at UCSF encompasses studies on the regulation of the eukaryotic cell division cycle, exploration of the machinery and the control of programmed cell death (apoptosis), regulation of cellular lifespan and the acquisition of cellular immortality, the control of DNA repair, the role of the immune system in cancer initiation and progression, tumor angiogenesis, cell invasion and metastasis and the design and application of mouse models of human cancer. Information of the broad range of cancer research activities can be found at the Cancer Center webpage.

 

Participating Faculty

Jennifer Grandis, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Translational Head and Neck Cancer Research

Clay Gustafson, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Immunology
Research Summary: 
Novel targeted therapeutic development for neuroblastoma and other MYC driven cancers

Akiko Hata, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Vascular & Cardiac Biology
Research Summary: 
TGFbeta family of signaling pathway

Matthias Hebrok, PhD

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Investigate the mechanisms underlying pancreatic diseases, including diabetes and pancreatic cancer, in order to gain novel insights that can be translated into therapeutic treatments for patients suffering from these diseases.

Holly Ingraham, PhD

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Mechanisms of Hormone Action in Organ Development and Disease

Roshanak Irannejad, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Organelle-based signaling in cardiovascular biology

Natalia Jura, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Vascular & Cardiac Biology
Research Summary: 
Molecular basis for Receptor Tyrosine Kinase signaling across the plasma membrane

Noriyuki Kasahara, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Development of gene therapy, oncolytic virotherapy, and immunotherapy for translational application to cancer (particularly CNS tumors), and genetic engineering strategies for regenerative medicine.

Yuriy Kirichok, PhD

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Biophysics and Physiology of Mitochondrial Membranes

Scott Kogan, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Cooperating Events in Myeloid Leukemogenesis and Their Reversal

Terumi Kohwi-Shigematsu, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Genome organizer function in cancer metastasis and in cell development

Max Krummel, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
The Immune Response in 4 Dimensions

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