Cancer Biology & Cell Signaling

The UCSF Helen Diller Family Comprehensive Cancer Center is an interdisciplinary initiative that combines basic science, clinical research, epidemiology/cancer control, and patient care throughout the University of California, San Francisco. The Center's mission is the discovery and evolution of new ideas and information about cancer, from basic research to clinical implementation.


UCSF's long tradition of excellence in cancer research includes, notably, Nobel Prize-winning work of J. Michael Bishop and Harold Varmus, who discovered cancer-causing oncogenes. Their work opened new doors for exploring genetic mistakes that cause cancer and formed the basis for some of the most important cancer research happening today.


Basic scientific research underpins all of our efforts to design and evaluate new tools to treat cancer patients everywhere. Hence, cancer research at UCSF encompasses studies on the regulation of the eukaryotic cell division cycle, exploration of the machinery and the control of programmed cell death (apoptosis), regulation of cellular lifespan and the acquisition of cellular immortality, the control of DNA repair, the role of the immune system in cancer initiation and progression, tumor angiogenesis, cell invasion and metastasis and the design and application of mouse models of human cancer. Information of the broad range of cancer research activities can be found at the Cancer Center webpage.

 

Participating Faculty

Jeroen Roose

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
None
Research Summary: 
Our goal is to understand how different flavors of receptor triggered Ras signals drive normal developmental processes of various cell types and organ systems and how (and why) perturbations of Ras-kinase signals cause human disease

Kole Roybal, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Control and Customization of Immune Cell Responses: Engineering new synthetic receptors, signal transduction cascades, and immune cell behaviors for cell therapies for cancer and autoimmunity

James Rubenstein, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Immunology

Davide Ruggero, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Dynamics of translation control in gene expression, cancer, and disease

Hilde Schjerven, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Normal and malignant blood cell development, including break of immune tolerance (autoimmunity) and blood cell cancer (leukemia), with a focus on transcriptional regulation.

Bjoern Schwer, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Genomic instability and DNA repair in neural cells

Neil Pravin Shah, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
None
Research Summary: 
Improving targeted therapeutics for hematologic malignancies

Kevin Shannon, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Aberrant Ras Signaling in Development and Cancer

Catherine Smith, MD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
None
Research Summary: 
Genetic Determinants of Resistance to AML Therapy

David Solomon, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Molecular mechanisms governing chromosomal instability and oncogenesis

Matthew Spitzer, PhD

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Systems approaches to understand immune responses, particularly to cancer

Matthew Stachler, MD, PhD

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
We strive to understand the events that drive progression of pre-malignant disease into invasive cancer, focusing on gastric and esophageal adenocarcinoma.

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