Jeroen Roose

Professor
Department of Anatomy
+1 415 476-3977
Research Overview: 

The Roose lab focuses on understanding cell fate decisions driven by cell-cell interactions and signaling pathways, in the context of cancer, autoimmune diseases, and COVID-19. Our collaborative research programs benefit from many technology platforms, such as organoids, CyTOF, single cell RNAseq, spectral flow, mouse models, and patient samples. Dr. Roose is a co-founder of the Bakar ImmunoX initiative at UCSF and a co-lead investigator on the UCSF Endeavor Program that focuses on cancer metastasis, funded through the Mark Foundation for Cancer Research.

Most recently, we have identified rules of epithelial-immune cell crosstalk in metastatic cancer (Gonzalez, Cell 2022. PMID35063085), we have developed organoids co-cultured with immune cells (unpublished work), and we are testing hypotheses of the crosstalk in organoids, informed by large omics datasets.

Couple of words about myself; I trained with Profs. Hans Clevers and Art Weiss, obtaining cancer- and immune- expertise. I started my own group at UCSF in 2007, I am now full Professor and also Vice Chair of my Anatomy Department at UCSF.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Immunology
Research Summary: 
My lab focuses on understanding cell fate decisions driven by cell-cell interactions and signaling pathways, in the context of immunology, cancer, and stem cell biology.

Websites

Publications: 

Immediate myeloid depot for SARS-CoV-2 in the human lung.

Research square

Looney M, Magnen M, You R, Rao A, Davis R, Rodriguez L, Simoneau C, Hysenaj L, Hu K, Love C, Woodruff P, Erle D, Hendrickson C, Calfee C, Matthay M, Roose J, Sil A, Ott M, Langelier C, Krummel M

Immediate myeloid depot for SARS-CoV-2 in the human lung.

bioRxiv : the preprint server for biology

Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR

Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice.

Leukemia

Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J

Cellular architecture of human brain metastases.

Cell

Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z

Editorial overview: Communities in immune cell signaling.

Current opinion in immunology

Roose J, Barton G