Hani Goodarzi, PhD

Assistant Professor
Department of Biochemistry and Biophysics
Department of Urology
+1 415 230-5189
Research Overview: 

Cancer, fundamentally, is a disease of disordered gene expression. Cancer cells rely on deregulated expression of oncogenic and tumor suppressive pathways to initiate and maintain the transformation process. Thus, delineating how cancer cells achieve such pathologic gene expression states is a crucial step towards understanding and ultimately treating cancer as a disease. Towards achieving this goal, my laboratory employs a systems biological and multidisciplinary approach that integrates computational and experimental strategies to identify and characterize key regulatory programs that underlie cancer progression. The systems-level frameworks implemented in our lab ensure a truly unbiased and systematic approach to studying this key biological challenge. Such bottom-up and agnostic approaches are crucial for discovering pathways that fall outside of our prior knowledge of regulatory interactions and would otherwise remain hidden in a top-down reductionist framework.

Featured publications:

 Goodarzi H, Nguyen HCB, Zhang S, Dill BD, Molina H, Tavazoie SF (2016). Modulated expression of specific tRNAs drives gene expression and cancer progression. Cell, 165(6), 1416-27. PMCID: PMC4915377. Co-corresponding authors

 Goodarzi H, Liu X, Nguyen HCB, Zhang S, Fish L, Tavazoie SF (2015). Endogenous tRNA-derived fragments suppress breast cancer progression. Cell 161, 1-13. PMCID: PMC4457382.

 Goodarzi H, Zhang S, Buss CG, Fish L, Tavazoie S, Tavazoie SF (2014). Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins. Nature, 513(7517):256-60. PMCID: PMC4440807.

Oikonomou P*, Goodarzi H*, Tavazoie S (2014). Systematic Identification of Regulatory Elements in Conserved 3’ UTRs of Human Transcripts. Cell Reports 7(1): p281–292. PMCID: PMC4430845. *Equal contribution

Goodarzi H, Najafabadi HS, Oikonomou P, Greco TM, Fish L, Salavati R, Cristea IM, Tavazoie S (2012). Systematic discovery of structural elements governing stability of mammalian messenger RNAs. Nature, 485, 264-268. PMCID: PMC3350620

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Our lab focuses on developing computational and experimental strategies to reveal and mechanistically characterize novel regulatory pathways that drive cancer metastasis.

Websites

Publications: 

A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression.

The EMBO journal

Huh D, Passarelli MC, Gao J, Dusmatova SN, Goin C, Fish L, Pinzaru AM, Molina H, Ren Z, McMillan EA, Asgharian H, Goodarzi H, Tavazoie SF

Massively multiplex single-molecule oligonucleosome footprinting.

eLife

Abdulhay NJ, McNally CP, Hsieh LJ, Kasinathan S, Keith A, Estes LS, Karimzadeh M, Underwood JG, Goodarzi H, Narlikar GJ, Ramani V

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

Cell stem cell

Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F

Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.

Cell metabolism

Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, Birsoy K

Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis.

Nature

Tavora B, Mederer T, Wessel KJ, Ruffing S, Sadjadi M, Missmahl M, Ostendorf BN, Liu X, Kim JY, Olsen O, Welm AL, Goodarzi H, Tavazoie SF