Isha Jain, PhD

Sandler Fellow
+1 415 502-3119
Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
We study how organisms interact with the environment -- more specifically, what happens when there are variations in oxygen levels in the atmosphere or vitamin/cofactor levels in the diet.
Mentorship Development: 

11/10/20    Optimizing the Efficiency of Your Lab



Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells.

Science (New York, N.Y.)

Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J

Turning the Oxygen Dial: Balancing the Highs and Lows.

Trends in cell biology

Baik AH, Jain IH

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.


Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.

Cell metabolism

Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM