Isha Jain, PhD | Biomedical Sciences Graduate Program

Assistant Professor

Primary Thematic Area

M_Biochemistry and Biophysics

Secondary Thematic Area

Research Summary

We study how organisms interact with the environment -- more specifically, what happens when there are variations in oxygen levels in the atmosphere or vitamin/cofactor levels in the diet.

Mentorship Development

11/2020 - Optimizing the Efficiency of Your Lab

[email protected]

Websites

Jain Lab

Publications

Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury.

bioRxiv : the preprint server for biology

Upadhyay V, Ortega EF, Ramirez Hernandez LA, Alexander M, Kaur G, Trepka K, Rock RR, Shima RT, Cheshire WC, Alipanah-Lechner N, Calfee CS, Matthay MA, Lee JV, Goga A, Jain IH, Turnbaugh PJ

HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity.

Cell

Blume SY, Garg A, Martí-Mateos Y, Midha AD, Chew BTL, Lin B, Yu C, Dick R, Lee PS, Situ E, Sarwaikar R, Green E, Ramanan V, Grotenbreg G, Hoek M, Sinz C, Jain IH

The single-molecule accessibility landscape of newly replicated mammalian chromatin.

Cell

Ostrowski MS, Yang MG, McNally CP, Abdulhay NJ, Wang S, Renduchintala K, Irkliyenko I, Biran A, Chew BTL, Midha AD, Wong EV, Sandoval J, Jain IH, Groth A, Nora EP, Goodarzi H, Ramani V

In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.

Science advances

Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH

Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.

Molecular cell

Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH

Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.

Cell metabolism

Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, Fong COY, Blecha JE, VanBrocklin H, Seo Y, Jain IH

The Goldilocks Oxygen Principle: not too little and not too much.

Nature cardiovascular research

Flanigan WR, Jain IH

Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer.

Cancer discovery

Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM

Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells.

Science (New York, N.Y.)

Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J

Turning the Oxygen Dial: Balancing the Highs and Lows.

Trends in cell biology

Baik AH, Jain IH

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.

Cell

Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.

Cell metabolism

Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM

Hypoxia as a therapy for mitochondrial disease.

Science (New York, N.Y.)

Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK

Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria.

Proceedings of the National Academy of Sciences of the United States of America

Jain IH, Vijayan V, O'Shea EK

A high resolution map of a cyanobacterial transcriptome.

Genome biology

Vijayan V, Jain IH, O'Shea EK

The making of a young scientist.

Developmental dynamics : an official publication of the American Association of Anatomists

Jain I, Iovine K

Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration.

Developmental biology

Hoptak-Solga AD, Nielsen S, Jain I, Thummel R, Hyde DR, Iovine MK

Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation.

Developmental dynamics : an official publication of the American Association of Anatomists

Jain I, Stroka C, Yan J, Huang WM, Iovine MK