Trever Bivona, MD, PhD

Associate Professor
Member, UCSF Helen Diller Family Comprehensive Cancer Center
Member, QB3
Departments of Medicine
Department of Cellular and Molecular Pharmacology
Research Overview: 

The Bivona lab conducts genetic and cell biological studies to uncover the fundamental principles that underlie the aberrant cell signaling events driving tumor initiation, progression, and drug resistance. The overall goal of this integrative research program is to understand the regulatory events underlying cancer cell growth through hypothesis-driven, laboratory-based investigations in order to improve cancer therapy and cancer patient survival.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Molecular characterization and precision treatment of solid cancers.

Websites

Publications: 

Betacellulin drives therapy-resistance in glioblastoma.

Neuro-oncology

Fan Q, An Z, Wong RA, Luo X, Lu E, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA

Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation-positive lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Rotow JK, Gui P, Wu W, Raymond VM, Lanman RB, Kaye FJ, Peled N, Fece de la Cruz F, Nadres B, Corcoran RB, Yeh I, Bastian BC, Starostik P, Newsom K, Olivas V, Wolff AM, Fraser JS, Collisson EA, McCoach CE, Camidge DR, Pacheco J, Bazhenova L, Li T, Bivona TG, Blakely CM

BRAF Mutations Classes I, II, and III in NSCLC Patients Included in the SLLIP Trial: The Need for a New Pre-Clinical Treatment Rationale.

Cancers

Bracht JWP, Karachaliou N, Bivona T, Lanman RB, Faull I, Nagy RJ, Drozdowskyj A, Berenguer J, Fernandez-Bruno M, Molina-Vila MA, Rosell R

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.

Cell reports

Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, Asthana S, Ideker T, Wu W, Suzuki J, Barad BA, Kirichok Y, Fraser JS, Weiss WA, Krogan NJ, Tulpule A, Sabnis AJ, Bivona TG