The Sirota Lab aims to develop computational integrative methods to inform disease diagnostics and therapeutics. Our goal is to integrate different types of omics and clinical data to better understand the role of the immune system in disease.
We strive to understand the events that drive progression of pre-malignant disease into invasive cancer, focusing on gastric and esophageal adenocarcinoma.
We aim to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions that modulate body composition and metabolism.
We seek to understand how the organization of the nucleus is established, specialized across cell types, and maintained over time to influence cellular identity.
Mentorship Development:
11/2019 - Equity and Inclusion in the Lab (2 hours)
11/2020 - Optimizing the Efficiency of Your Lab
5/2021 - Sharpening your Mentoring Skills (SyMS)
1/2022 - Equity Based Interview Practices
