Brian Feldman, MD, PhD

Assoc Professor In Residence
Pediatrics
+1 415 514-0610
Research Description: 

Brian Feldman, MD, PhD
Walter L. Miller Distinguished Professor
University of California, San Francisco
Department of Pediatrics
Division of Pediatric Endocrinology

A major focus of the Feldman Laboratory is to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions. We are particularly interested in identifying novel pathways that modulate body composition and metabolism. We apply molecular, cellular and in vivo approaches to define these physiological signals as well as examine how perturbations in these pathways can lead to diseases such as diabetes.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
We aim to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions that modulate body composition and metabolism.
Featured Publications: 

The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15.

Cell reports

Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ

Macrophage-released ADAMTS1 promotes muscle stem cell activation.

Nature communications

Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ

A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo.

Science signaling

Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ

Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis.

Endocrinology

Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ

A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes.

Nature medicine

Zhang B, Kumar RB, Dai H, Feldman BJ