We study tumor evolution, drug sensitization and oncogene network alterations in patients in order to improve precision medicine therapies for hormone-related and genitourinary cancers.
Mentorship Development:
5/2021 - Sharpening your Mentoring Skills (SyMS)
6/2022 - Career Conversations
Systems approaches to understand immune responses, particularly to cancer
Mentorship Development:
3/3/20 Promoting Student Mental Health:A Presentation and Discussion (Staff and Faculty)
11/10/20 Optimizing the Efficiency of Your Lab
12/8/20 Setting Expectations with a "Welcome to the Lab' Letter (Parts 1 and 2)
Normal and malignant blood cell development, including break of immune tolerance (autoimmunity) and blood cell cancer (leukemia), with a focus on transcriptional regulation.
Mentorship Development:
12/12/19 ACRA: Setting Training Expectations for Trainees on the Academic Career Track (1.5 hours)
3/3/20 Promoting Student Mental Health:A Presentation and Discussion (Staff and Faculty)
3/3/20 Promoting Student Mental Health: Faculty Workshop (Faculty only)
4/23/20 Effective Strategies for IDPs
11/10/20 Optimizing the Efficiency of Your Lab
2/18/21 Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels
We are molecularly modifying pluripotent stem cell lines to create non-immunogenic cells that are protected from post-transplant rejection without affecting the general immune system.
4/2019 - Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/2021 - Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels
6/2022 - Career Conversations
11/2022 - Faculty Development Program: Supervising People Who Aren't You: Mentoring/Managing Different Work Styles
We develop and apply innovative approaches, such as CRISPR-based functional genomics, in human iPSC-derived neurons and glia and mouse models to elucidate mechanisms and therapeutic strategies for neurodegenerative diseases.
Mentorship Development:
4/12/19 Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
4/30/20 Mental Health in a Pandemic: Q&A for Faculty
6/10/20 Tools and Tips for Virtual Learning
10/22/20 Gathering in Community: a Training for Faculty and Staff
9/11/20 Mentoring Across Differences
9/24/20 DEI Champions Training
We study T cell immunity to tuberculosis (TB). In mice, we characterize mechanisms of CD4 T cell evasion in TB, and we study humans to discover mechanisms that provide protective immunity to TB that can be improved by vaccines.
Mechanisms of signaling and trafficking at the primary cilium, biogenesis of extracellular vesicles.
Mentorship Development:
12/19/19 ACRA: Setting Training Expectations for Trainees on the Academic Career Track (1.5 hours)
12/8/20 Setting Expectations with a "Welcome to the Lab' Letter (Parts 1 and 2)
Our program explores the impact of metabolic stress on deregulated micro-RNA controlled hematopoiesis and immune cell function in the pathogenesis of atherosclerosis, including through intercellular signaling via exosomes
