Ross Okimoto, MD

Asst. Professor in Residence
Medicine
Research Overview: 

The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis. We use in vivo model systems to study the functional output of perturbed molecular networks and seek to develop new therapies to target transcriptional dependence in cancer.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis.
Publications: 

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.

Science (New York, N.Y.)

Quinn JJ, Jones MG, Okimoto RA, Nanjo S, Chan MM, Yosef N, Bivona TG, Weissman JS

Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis.

Oncogenesis

Nothdurft S, Thumser-Henner C, Breitenbücher F, Okimoto RA, Dorsch M, Opitz CA, Sadik A, Esser C, Hölzel M, Asthana S, Forster J, Beisser D, Kalmbach S, Grüner BM, Bivona TG, Schramm A, Schuler M

Capicua in Human Cancer.

Trends in cancer

Kim JW, Ponce RK, Okimoto RA

Negative MAPK-ERK regulation sustains CIC-DUX4 oncoprotein expression in undifferentiated sarcoma.

Proceedings of the National Academy of Sciences of the United States of America

Lin YK, Wu W, Ponce RK, Kim JW, Okimoto RA

CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs.

The Journal of clinical investigation

Okimoto RA, Wu W, Nanjo S, Olivas V, Lin YK, Ponce RK, Oyama R, Kondo T, Bivona TG