Ross Okimoto, MD

Assoc. Professor in Residence
Primary Thematic Area
M_MED-CORE-HMON-ONCO-GEN
Secondary Thematic Area
Research Summary
The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis.

The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis. We use in vivo model systems to study the functional output of perturbed molecular networks and seek to develop new therapies to target transcriptional dependence in cancer.

Publications

Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature communications

Gounder MM, Agaram NP, Trabucco SE, Robinson V, Ferraro RA, Millis SZ, Krishnan A, Lee J, Attia S, Abida W, Drilon A, Chi P, Angelo SP, Dickson MA, Keohan ML, Kelly CM, Agulnik M, Chawla SP, Choy E, Chugh R, Meyer CF, Myer PA, Moore JL, Okimoto RA, Pollock RE, Ravi V, Singh AS, Somaiah N, Wagner AJ, Healey JH, Frampton GM, Venstrom JM, Ross JS, Ladanyi M, Singer S, Brennan MF, Schwartz GK, Lazar AJ, Thomas DM, Maki RG, Tap WD, Ali SM, Jin DX

Inactivation of Capicua drives cancer metastasis.

Nature genetics

Okimoto RA, Breitenbuecher F, Olivas VR, Wu W, Gini B, Hofree M, Asthana S, Hrustanovic G, Flanagan J, Tulpule A, Blakely CM, Haringsma HJ, Simmons AD, Gowen K, Suh J, Miller VA, Ali S, Schuler M, Bivona TG

Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene.

American journal of human genetics

Wagner A, Barrows A, Wijnen JT, van der Klift H, Franken PF, Verkuijlen P, Nakagawa H, Geugien M, Jaghmohan-Changur S, Breukel C, Meijers-Heijboer H, Morreau H, van Puijenbroek M, Burn J, Coronel S, Kinarski Y, Okimoto R, Watson P, Lynch JF, de la Chapelle A, Lynch HT, Fodde R