Ross Okimoto, MD

Asst. Professor in Residence

Medicine

Research Overview:

The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis. We use in vivo model systems to study the functional output of perturbed molecular networks and seek to develop new therapies to target transcriptional dependence in cancer.

Primary Thematic Area:

Cancer Biology & Cell Signaling

Secondary Thematic Area:

Human Genetics

Research Summary:

The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis.

Publications:

Mapping chromatin state and transcriptional response in CIC-DUX4 undifferentiated round cell sarcoma.

bioRxiv : the preprint server for biology

Thomas NJ, Luck C, Shlimon N, Ponce RK, Kosibaty Z, Okimoto RA

The <i>CIC-ERF</i> co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression.

eLife

Gupta N, Song H, Wu W, Ponce RK, Lin YK, Kim JW, Small EJ, Feng FY, Huang FW, Okimoto RA

Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer.

Cell reports

Kim JW, Luck C, Wu W, Ponce RK, Lin YK, Gupta N, Okimoto RA

Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function.

PLoS biology

Bennett NK, Nakaoka HJ, Laurent D, Okimoto RA, Sei Y, Horvai AE, Bivona TG, Ten Hoeve J, Graeber TG, Nakamura K, Nakamura JL

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer.

The Journal of clinical investigation

Nanjo S, Wu W, Karachaliou N, Blakely CM, Suzuki J, Chou YT, Ali SM, Kerr DL, Olivas VR, Shue J, Rotow J, Mayekar MK, Haderk F, Chatterjee N, Urisman A, Yeo JC, Skanderup AJ, Tan AC, Tam WL, Arrieta O, Hosomichi K, Nishiyama A, Yano S, Kirichok Y, Tan DS, Rosell R, Okimoto RA, Bivona TG