Ross Okimoto, MD

Assoc. Professor in Residence
Medicine
[email protected]
Research Overview: 

The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis. We use in vivo model systems to study the functional output of perturbed molecular networks and seek to develop new therapies to target transcriptional dependence in cancer.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis.
Publications: 

The Capicua C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein.

Cancer research communications

Luck C, Jacobs KA, Okimoto RA

A Platform to Deliver Single and Bi-specific Cas9/guide RNA to Perturb Genes in Vitro and in Vivo.

Molecular therapy : the journal of the American Society of Gene Therapy

Li YJ, Chien SH, Huang R, Herrmann A, Zhao Q, Li PC, Zhang C, Martincuks A, Santiago NL, Zong K, Swiderski P, Okimoto RA, Song M, Rodriguez L, Forman SJ, Wang X, Yu H

The Capicua C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein.

bioRxiv : the preprint server for biology

Luck C, Jacobs KA, Okimoto RA

Molecular and therapeutic advancements in Capicua (CIC)-rearranged sarcoma.

Frontiers in cell and developmental biology

Ponce RKM, Luck C, Okimoto RA

Quantification of cerebrospinal fluid tumor DNA in lung cancer patients with suspected leptomeningeal carcinomatosis.

NPJ precision oncology

Azad TD, Nanjo S, Jin MC, Chabon JJ, Kurtz DM, Chaudhuri AA, Connolly ID, Hui AB, Liu CL, Merriott D, Ko R, Yoo C, Carter J, Chen E, Bonilla R, Hata A, Katakami N, Irie K, Yano S, Okimoto R, Bivona TG, Newman AM, Iv M, Nagpal S, Gephart MH, Alizadeh AA, Diehn M