Ross Okimoto, MD

Asst. Professor in Residence
Medicine
Research Overview: 

The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis. We use in vivo model systems to study the functional output of perturbed molecular networks and seek to develop new therapies to target transcriptional dependence in cancer.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis.
Publications: 

Capicua in Human Cancer.

Trends in cancer

Kim JW, Ponce RK, Okimoto RA

Negative MAPK-ERK regulation sustains CIC-DUX4 oncoprotein expression in undifferentiated sarcoma.

Proceedings of the National Academy of Sciences of the United States of America

Lin YK, Wu W, Ponce RK, Kim JW, Okimoto RA

CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs.

The Journal of clinical investigation

Okimoto RA, Wu W, Nanjo S, Olivas V, Lin YK, Ponce RK, Oyama R, Kondo T, Bivona TG

Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.

Molecular cell

Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H

Metastasis: From head to tail.

Cell cycle (Georgetown, Tex.)

Okimoto RA, Bivona TG