Matthew Spitzer, PhD

Associate Professor
Otolaryngology
Research Description: 

The Spitzer Lab is working to develop our understanding of how the immune system coordinates its responses across the organism with an emphasis on tumor immunology. We combine methods in experimental immunology and cancer biology with computation to understand the modes in which the immune system can respond to tumors and to rationally initiate curative immune responses against cancer.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Systems approaches to understand immune responses, particularly to cancer
Mentorship Development: 

3/3/20    Promoting Student Mental Health:A Presentation and Discussion (Staff and Faculty)
11/10/20    Optimizing the Efficiency of Your Lab
12/8/20    Setting Expectations with a "Welcome to the Lab' Letter (Parts 1 and 2)

Websites

Publications: 

Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states.

bioRxiv : the preprint server for biology

Babdor J, Patel RK, Davidson B, Noecker C, Rahim M, Bisanz JE, Tenvooren I, Marquez D, Calvo M, Johri V, McCarthy E, Shaheed A, Ekstrand C, Weakley AM, Yu FB, Fiehn O, Turnbaugh PJ, Combes AJ, Fragiadakis GK, Spitzer MH

T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation.

Cancer immunology research

Cho NW, Guldberg SM, Nabet BY, Yu JZ, Kim EJ, Hiam-Galvez KJ, Yee JL, DeBarge R, Tenvooren I, Ashitey NA, Lynce F, Dillon DA, Rosenbluth JM, Spitzer MH

A mass cytometry method pairing T cell receptor and differentiation state analysis.

Nature immunology

Garcia Castillo J, DeBarge R, Mende A, Tenvooren I, Marquez DM, Straub A, Busch DH, Spitzer MH, DuPage M

A Wireless, Multicolor Fluorescence Image Sensor Implant for Real-Time Monitoring in Cancer Therapy.

ArXiv

Roschelle M, Rabbani R, Gweon S, Kumar R, Vercruysse A, Cho NW, Spitzer MH, Niknejad AM, Stojanovic VM, Anwar M

Author Correction: Systemic dysfunction and plasticity of the immune macroenvironment in cancer models.

Nature medicine

Allen BM, Hiam KJ, Burnett CE, Venida A, DeBarge R, Tenvooren I, Marquez DM, Cho NW, Carmi Y, Spitzer MH