Matthew Spitzer, PhD

Associate Professor
Otolaryngology
[email protected]
Research Description: 

The Spitzer Lab is working to develop our understanding of how the immune system coordinates its responses across the organism with an emphasis on tumor immunology. We combine methods in experimental immunology and cancer biology with computation to understand the modes in which the immune system can respond to tumors and to rationally initiate curative immune responses against cancer.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Systems approaches to understand immune responses, particularly to cancer
Mentorship Development: 

3/3/20    Promoting Student Mental Health:A Presentation and Discussion (Staff and Faculty)
11/10/20    Optimizing the Efficiency of Your Lab
12/8/20    Setting Expectations with a "Welcome to the Lab' Letter (Parts 1 and 2)

Websites

Publications: 

Combination immunotherapy induces post-intervention control of HIV.

Research square

Peluso M, Sandel D, Deitchman A, Kim SJ, Dalhuisen T, Tummala H, Tiburcio R, Zemelko L, Borgo G, Singh S, Schwartz K, Deswal M, Williams M, Hoh R, Shimoda M, Narpala S, Serebryannyy L, Khalili M, Vendrame E, SenGupta D, Whitmore L, Tisoncik-Go J, Gale M, Koup R, Mullins J, Felber B, Pavlakis G, Reeves J, Petropoulos C, Glidden D, Spitzer M, Gama L, Caskey M, Nussenzweig M, Chew K, Henrich T, Yukl S, Cohn L, Deeks S, Rutishauser R

IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma.

bioRxiv : the preprint server for biology

Young JS, Cho NW, Lucas CG, Najem H, Mirchia K, Chen WC, Seo K, Zakimi N, Daggubati V, Casey-Clyde T, Nguyen MP, Chen A, Phillips JJ, Ozawa T, Aghi MK, Taylor JW, DeRisi JL, Bhaduri A, Berger MS, Heimberger AB, Butowski N, Spitzer MH, Raleigh DR

Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade.

Journal for immunotherapy of cancer

Moore J, Gkantalis J, Guix I, Chou W, Yuen K, Lazar AA, Spitzer M, Combes A, Barcellos-Hoff MH

Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancer.

bioRxiv : the preprint server for biology

Mestrallet G, Brown M, Vaninov N, Cho NW, Velazquez L, Ananthanarayanan A, Spitzer M, Vabret N, Bozkus CC, Samstein RM, Bhardwaj N

T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation.

Cancer immunology research

Cho NW, Guldberg SM, Nabet BY, Yu JZ, Kim EJ, Hiam-Galvez KJ, Yee JL, DeBarge R, Tenvooren I, Ashitey NA, Lynce F, Dillon DA, Rosenbluth JM, Spitzer MH