Sonja Schrepfer, MD, PhD

Associate Professor of Surgery
Surgery
+1 415 502-8742
Primary Thematic Area: 
Vascular & Cardiac Biology
Secondary Thematic Area: 
Immunology
Research Summary: 
We are molecularly modifying pluripotent stem cell lines to create non-immunogenic cells that are protected from post-transplant rejection without affecting the general immune system.
Featured Publications: 

Immunobiology of fibrin-based engineered heart tissue.

Stem cells translational medicine

Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S

SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.

Cell stem cell

Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.

Nature

Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S

Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.

Circulation

Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S

Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.

Proceedings of the National Academy of Sciences of the United States of America

Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Sheikh AY, Haddad M, Connolly AJ, Davis MM, Robbins RC, Wu JC