The central theme of the Chorba Lab is to model clinically relevant phenomena in a controlled environment. The major goals are to develop new therapies, targets, and diagnostics that change paradigms in medicine. Inspired by clinical practice, we 1) develop biochemical tools and 2) tackle seemingly undruggable targets to 3) understand the mechanistic basis of cardiometabolic disease and beyond. We work at the interface of chemistry and biology, using the bidirectionality of bench-to-bedside research to expand our findings from any given disease model to the fundamental biology at play.
Our team studies how chromatin receives, processes, and amplifies environmental stress signals that drive changes in cell states leading to heart disease.
My research is focused on uncovering the mechanisms and development of new therapies for the cerebrovascular diseases including brain vascular malformations, stroke, and cognitive dysfunction.
We are molecularly modifying pluripotent stem cell lines to create non-immunogenic cells that are protected from post-transplant rejection without affecting the general immune system.
Our program explores the impact of metabolic stress on deregulated micro-RNA controlled hematopoiesis and immune cell function in the pathogenesis of atherosclerosis, including through intercellular signaling via exosomes
