Marina Sirota, PhD

Assoc Professor in Residence
Bakar Computational Health Sciences Institute (BCHSI)
Research Description: 

Marina is currently an Assistant Professor at the Institute for Computational Health Sciences at UCSF. Prior to that she was the Lead Research Scientist in the Division of Systems Medicine at Stanford University and has worked as a Senior Research Scientist at Pfizer where she focused on developing Precision Medicine strategies in drug discovery. She completed her PhD in Biomedical Informatics at Stanford University, where her graduate work focused on predicting drug-disease relationships based on gene expression to identify novel therapeutic indications for known drugs. Her research interests lie in developing computational integrative methods and applying these approaches in the context of disease diagnostics and therapeutics. Her primary focus is on leveraging and integrating different types of omics and clinical data to better understand the role of the immune system in disease.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Immunology
Research Summary: 
The Sirota Lab aims to develop computational integrative methods to inform disease diagnostics and therapeutics. Our goal is to integrate different types of omics and clinical data to better understand the role of the immune system in disease.

Websites

Featured Publications: 

Discovery and preclinical validation of drug indications using compendia of public gene expression data.

Science translational medicine

Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, Sage J, Butte AJ

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.

Science translational medicine

Dudley JT, Sirota M, Shenoy M, Pai RK, Roedder S, Chiang AP, Morgan AA, Sarwal MM, Pasricha PJ, Butte AJ

B cell exchange across the blood-brain barrier in multiple sclerosis.

The Journal of clinical investigation

von Büdingen HC, Kuo TC, Sirota M, van Belle CJ, Apeltsin L, Glanville J, Cree BA, Gourraud PA, Schwartzburg A, Huerta G, Telman D, Sundar PD, Casey T, Cox DR, Hauser SL

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis.

Science translational medicine

Palanichamy A, Apeltsin L, Kuo TC, Sirota M, Wang S, Pitts SJ, Sundar PD, Telman D, Zhao LZ, Derstine M, Abounasr A, Hauser SL, von Büdingen HC

Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing.

Nature communications

Pineda S, Sigdel TK, Liberto JM, Vincenti F, Sirota M, Sarwal MM

Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth.

Frontiers in immunology

Vora B, Wang A, Kosti I, Huang H, Paranjpe I, Woodruff TJ, MacKenzie T, Sirota M