Immunology

The Bhattacharya Laboratory studies the effect of macrophages on fibroblast activation during the fibrotic phase of tissue injury, with a focus on lung fibrosis.

Identify underlying mechanisms of brain tumor immunosuppression and evasion, with the goal to develop novel immunotherapies for brain cancer.

Our group uses novel gene engineering strategies to decode key genetic programs that we can target to rewire immune cells into effective cancer treatments.

Using single cell genomics and tissue imaging, we study the cellular interactions that shape immune responses in human tumors in order to harness the immune system in the fight against cancer.

We are broadly interested in how the molecular properties of viral proteins and antibodies constrain their evolution and co-evolution.

Discover and dissect recurring patterns of the immune system.

We study host and pathogen mechanisms that regulate growth of Mycobacterium tuberculosis and other mycobacteria. We are using proteomic and genetic tools to probe host responses to infection in macrophages and animal models.

Profiling states of the human immune system and immune-microbiome interactions using single-cell methods

Decoding the role of allergic immunity in tissue health

We are designing synthetic receptors and editing the T cell’s genome to better understand T cells function within the tumor microenvironment and ultimately design safe and efficient adoptive T cell therapies