Immunology

We study how the innate immune system (the body’s first line of immune defense) evolves to defend us against the vast and fast-changing world of viruses.

The Cho Lab is focused on understanding principles of molecular and cellular interactions between cancer and immunity.

Molecular regulation of neuroimmune circuits and cytokines in barrier tissue inflammation

Our group develops and applies advances in synthetic biology to better understand biological systems and then to re-engineer these systems to tackle disease.

We develop new approaches to decipher communication between the brain and immune system. We study what these messages mean, how they’re regulated, and how they impact brain health.

We are interested in understanding how dysfunctional hematopoiesis leads to dysfunctional immune cells which can modulate cardiovascular disease.

NK cells, NK receptors, and NK ligands in viral immunity and tumor immunity.

We use synthetic biology and high-throughput functional genetic screens to understand antigen presentation and T-cell recognition in the context of cancer and other diseases.

Mechanisms of Macrophage-Mediated Cell Clearance

Mechanisms underlying transcriptional dysregulation, DNA damage responses, inflammation and resistance. Design theranostics targeting the cancer surface proteome and define synthetic lethal interactions.