Trevor Fidler, PhD

Assistant Professor In Res
Cardiovascular Research Inst
[email protected]
+1 415 514-8082
Primary Thematic Area: 
Vascular & Cardiac Biology
Secondary Thematic Area: 
Immunology
Research Summary: 
We are interested in understanding how dysfunctional hematopoiesis leads to dysfunctional immune cells which can modulate cardiovascular disease.
Publications: 

An epigenetic switch in macrophages promotes fibrosis in the failing heart.

Nature cardiovascular research

Tall AR, Fidler TP

Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis.

Nature cardiovascular research

Fidler TP, Dunbar A, Kim E, Hardaway B, Pauli J, Xue C, Abramowicz S, Xiao T, O'Connor K, Sachs N, Wang N, Maegdefessel L, Levine R, Reilly M, Tall AR

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.

The Journal of clinical investigation

Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P

Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging.

Arteriosclerosis, thrombosis, and vascular biology

Sonkar VK, Eustes AS, Ahmed A, Jensen M, Solanki MV, Swamy J, Kumar R, Fidler TP, Houtman JCD, Allen BG, Spitz DR, Abel ED, Dayal S