Trevor Fidler, PhD

Assistant Professor In Res
Cardiovascular Research Inst
+1 415 514-8082
Primary Thematic Area: 
Vascular & Cardiac Biology
Secondary Thematic Area: 
Research Summary: 
We are interested in understanding how dysfunctional hematopoiesis leads to dysfunctional immune cells which can modulate cardiovascular disease.

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.

The Journal of clinical investigation

Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P

Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging.

Arteriosclerosis, thrombosis, and vascular biology

Sonkar VK, Eustes AS, Ahmed A, Jensen M, Solanki MV, Swamy J, Kumar R, Fidler TP, Houtman JCD, Allen BG, Spitz DR, Abel ED, Dayal S

Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis.

The Journal of clinical investigation

Liu W, Östberg N, Yalcinkaya M, Dou H, Endo-Umeda K, Tang Y, Hou X, Xiao T, Fidler TP, Abramowicz S, Yang YG, Soehnlein O, Tall AR, Wang N

Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein.

Scientific reports

Yalcinkaya M, Liu W, Islam MN, Kotini AG, Gusarova GA, Fidler TP, Papapetrou EP, Bhattacharya J, Wang N, Tall AR