Cancer Biology & Cell Signaling

Our lab uses cancer genomics to study the molecular mechanisms of carcinogenesis, cancer disparities, and cellular immortality.

Calcium signaling in primary cilia during development and disease

We develop and apply biomimetic human tissue models to dissect mechanisms of morphogenesis and mechanobiology as applied to cancer and cardiovascular disease.

Development of gene therapy, oncolytic virotherapy, and immunotherapy for translational application to cancer (particularly CNS tumors), and genetic engineering strategies for regenerative medicine.

Tolerogenic Antigen-Presenting Cells in the Immune System

Genome organizer function in cancer metastasis and in cell development

We strive to understand the events that drive progression of pre-malignant disease into invasive cancer, focusing on gastric and esophageal adenocarcinoma.

Computational and experimental approaches to guide the development of new precision medicines for cancer

The Okimoto lab aims to understand how transcriptional dysregulation leads to cancer growth and metastasis.

We study tumor evolution, drug sensitization and oncogene network alterations in patients in order to improve precision medicine therapies for hormone-related and genitourinary cancers.