Cancer Biology & Cell Signaling

We are designing synthetic receptors and editing the T cell’s genome to better understand T cells function within the tumor microenvironment and ultimately design safe and efficient adoptive T cell therapies

Mechanisms of Neurodegeneration in ALS and Dementia

Dr. Jennifer Y. Chen’s research program focuses on the development of novel antifibrotic therapies and biomarkers for patients with chronic liver disease.

Defining conserved mechanisms regulating stem cell behavior and how these are altered with age and in response to chronic or acute changes in metabolism.

Cellular and Molecular basis of nutrient-specific appetite.

Pathogenic Antigen-activated T cells in Autoimmune Disease

Gene regulation in health and disease

Sphingolipid signaling and metabolism in the pathophysiology and treatment of cancer, inflammatory conditions, and rare diseases

Our multi-disciplinary team works on identifying and characterizing novel oncogenes and tumor suppressors in melanocytic neoplasia and understanding their biology.

We study how organisms interact with the environment -- more specifically, what happens when there are variations in oxygen levels in the atmosphere or vitamin/cofactor levels in the diet.