Cancer Biology & Cell Signaling

Mechanisms underlying transcriptional dysregulation, DNA damage responses, inflammation and resistance. Design theranostics targeting the cancer surface proteome and define synthetic lethal interactions.

Our overarching goal is to understand the biology of skin cancer with an emphasis on melanoma and squamous cell carcinoma.

The Vasudevan Laboratory studies growth factor signaling through receptor tyrosine kinases and the Ras signaling pathway in development and cancer with an emphasis on neurofibromatosis.

Identify underlying mechanisms of brain tumor immunosuppression and evasion, with the goal to develop novel immunotherapies for brain cancer.

Our group uses novel gene engineering strategies to decode key genetic programs that we can target to rewire immune cells into effective cancer treatments.

Using single cell genomics and tissue imaging, we study the cellular interactions that shape immune responses in human tumors in order to harness the immune system in the fight against cancer.

The Gordan lab combines chemical biology with cancer systems biology strategies to identify new therapeutic targets and drug combinations for GI cancers.

Discover and dissect recurring patterns of the immune system.

Using Cardio-Oncology and Cardio-Immunology as platforms to understand cardiovascular signaling

Our lab develops new genome-scale methods to study mammalian chromatin structure and transcriptional regulation