Steven Altschuler, PhD

Pharmaceutical Chemistry
+1 415 502-3196
Research Description: 

Dr. Steven Altschuler is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. Dr. Altschuler also applies high-throughput technology developed by his laboratory to diverse problems, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Altschuler worked at UT Southwestern, Harvard, Rosetta Informatics, Microsoft, Princeton, and the Institute for Advanced Studies.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Research Summary: 
Investigate how complex biological networks regulate precise cellular behaviors and how dis-regulation leads to disease.
Mentorship Development: 

4/26/19    Sharpening your Mentoring Skills (SyMS) with Sharon Milgram (Mission Bay)
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels


Featured Publications: 

PhenoRipper: software for rapidly profiling microscopy images.

Nature methods

Rajaram S, Pavie B, Wu LF, Altschuler SJ

Network crosstalk dynamically changes during neutrophil polarization.


Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF

Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities.

Molecular systems biology

Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ

On the spontaneous emergence of cell polarity.


Altschuler SJ, Angenent SB, Wang Y, Wu LF

Multidimensional drug profiling by automated microscopy.

Science (New York, N.Y.)

Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ

Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines.

Nature biotechnology

Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF