My research aims to understand the barriers that prevent HIV cure, with a focus on determining the mechanism governing latent HIV infection and evaluating new therapies aimed to disrupt viral latency.
Development of gene therapy, oncolytic virotherapy, and immunotherapy for translational application to cancer (particularly CNS tumors), and genetic engineering strategies for regenerative medicine.
4/2019 - Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
2/2021 - Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels
6/2022 - Career Conversations
11/2022 - Faculty Development Program: Supervising People Who Aren't You: Mentoring/Managing Different Work Styles
We develop and apply innovative approaches, such as CRISPR-based functional genomics, in human iPSC-derived neurons and glia and mouse models to elucidate mechanisms and therapeutic strategies for neurodegenerative diseases.
Mentorship Development:
4/12/19 Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)
4/30/20 Mental Health in a Pandemic: Q&A for Faculty
6/10/20 Tools and Tips for Virtual Learning
10/22/20 Gathering in Community: a Training for Faculty and Staff
9/11/20 Mentoring Across Differences
9/24/20 DEI Champions Training
We study T cell immunity to tuberculosis (TB). In mice, we characterize mechanisms of CD4 T cell evasion in TB, and we study humans to discover mechanisms that provide protective immunity to TB that can be improved by vaccines.
Our lab applies single-cell analysis approaches on in vitro and clinical specimens to study the interplay between immune cells & viral pathogens including HIV & SARS-CoV-2, & to study the properties of immune cells in mucosal tissues in health & disease
Immunmodulatory, cytoreductive chemotherapeutic and stem cell transplantation approaches to HIV-1 cure. Design and implementation of novel nano/microtechnologies to characterize viral reservoirs.
Immune mechanisms that support host-commensal symbiosis
Mentorship Development:
11/23/20 Building Community in the UCSF MSTP
2/16/21 Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels
Genomic approaches to identifying causes and understanding the pathogenesis of autoimmune and infectious neuroinflammatory conditions including encephalitis, meningitis and multiple sclerosis, and developing cell-based therapies for treatment.
