Martin Kampmann, PhD

Asst Professor in Residence
Institute for Neurodegenerative Diseases
+1 415 514-5545

The Kampmann lab develops and uses innovative technologies to understand cellular and molecular mechanisms of human diseases, and to discover new therapeutic strategies.

A major focus of our research are diseases associated with protein misfolding, such as neurodegenerative diseases. We ask how cells maintain their proteins in a functional and balanced state. In human cells, this is accomplished by a network of over 1,000 different factors called the proteostasis network. Our goal is to understand how this network functions, and how it is challenged and rewired in disease states.

Our functional genomics technology, which integrates CRISPR/Cas9-based control of gene function and large-scale genetic interaction maps, enables us to elucidate dynamic networks and to pinpoint nodes that are potential therapeutic targets. CRISPRi and CRISPRa genetic screens in cells derived from human induced pluripotent stem cells (hiPSCs) can reveal mechanisms of disease-associated genes and of selective vulnerability of specific cell types. We use biochemistry, biophysics and cell biology to "zoom in" on individual nodes of the network and to reveal their mechanism of action.

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
We develop and apply innovative approaches, such as functional genomics in human iPSC-derived neurons and glia, to elucidate mechanisms and therapeutic strategies for neurodegenerative diseases.

Websites

Featured Publications: 

A CRISPR Approach to Neurodegenerative Diseases.

Trends in molecular medicine

Kampmann M

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Cell

Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America

Kampmann M, Bassik MC, Weissman JS

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.

Cell

Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.

eLife

Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M