Martin Kampmann, PhD

Assoc Professor in Residence
Institute for Neurodegenerative Diseases
+1 415 514-5545
Research Overview: 

The Kampmann lab develops and uses innovative technologies to understand cellular and molecular mechanisms of human diseases, and to discover new therapeutic strategies.

A major focus of our research are diseases associated with protein misfolding, such as neurodegenerative diseases. We ask how cells maintain their proteins in a functional and balanced state. In human cells, this is accomplished by a network of over 1,000 different factors called the proteostasis network. Our goal is to understand how this network functions, and how it is challenged and rewired in disease states.

Our functional genomics technology, which integrates CRISPR/Cas9-based control of gene function and large-scale genetic interaction maps, enables us to elucidate dynamic networks and to pinpoint nodes that are potential therapeutic targets. CRISPRi and CRISPRa genetic screens in cells derived from human induced pluripotent stem cells (hiPSCs) can reveal mechanisms of disease-associated genes and of selective vulnerability of specific cell types. We use biochemistry, biophysics and cell biology to "zoom in" on individual nodes of the network and to reveal their mechanism of action.

Primary Thematic Area: 
Secondary Thematic Area: 
Human Genetics
Research Summary: 
We develop and apply innovative approaches, such as functional genomics in human iPSC-derived neurons and glia, to elucidate mechanisms and therapeutic strategies for neurodegenerative diseases.
Mentorship Development: 

4/12/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Mission Bay)    
4/30/20    Mental Health in a Pandemic: Q&A for Faculty    
6/10/20    Tools and Tips for Virtual Learning    
10/22/20    Gathering in Community: a Training for Faculty and Staff    
9/11/20    Mentoring Across Differences
9/24/20    DEI Champions Training


Featured Publications: 

A CRISPR Approach to Neurodegenerative Diseases.

Trends in molecular medicine

Kampmann M

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.


Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America

Kampmann M, Bassik MC, Weissman JS

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.


Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.


Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M