Virology & Microbial Pathogenesis

NK cells, NK receptors, and NK ligands in viral immunity and tumor immunity.

We are broadly interested in how the molecular properties of viral proteins and antibodies constrain their evolution and co-evolution.

We study host and pathogen mechanisms that regulate growth of Mycobacterium tuberculosis and other mycobacteria. We are using proteomic and genetic tools to probe host responses to infection in macrophages and animal models.

Profiling states of the human immune system and immune-microbiome interactions using single-cell methods

We seek to identify the mechanisms and players supporting human cytomegalovirus transmission, spread and pathogenesis.

My lab utilizes genomic and proteomic technologies to study host/pathogen biology in the context of clinical outcomes, develop new diagnostics, and track outbreaks. Key Focus: Pneumonia (including COVID-19), ARDS, sepsis and emerging pathogen surveillance

CD8+ T cell immunity to viral pathogens (e.g., HIV, SARS-CoV2) and vaccination at various stages of human development.

Dissecting host mechanisms of tuberculosis (TB) pathogenesis and disease progression, defining immunological correlates of protection, and validating biomarkers and point-of-care diagnostics for TB and COVID-19

Fundamental mycobacterial physiology and host pathogen-interactions.

My research aims to understand the barriers that prevent HIV cure, with a focus on determining the mechanism governing latent HIV infection and evaluating new therapies aimed to disrupt viral latency.