Proceedings of the National Academy of Sciences of the United States of America

EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.

Proceedings of the National Academy of Sciences of the United States of America

Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C

Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Yamasaki E, Ali S, Sanchez Solano A, Thakore P, Smith M, Wang X, Labelle-Dumais C, Gould DB, Earley S

Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.

Proceedings of the National Academy of Sciences of the United States of America

Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.

Proceedings of the National Academy of Sciences of the United States of America

Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko DS, Moroz YS, Irwin JJ, Renslo AR, Taylor JC, Gestwicki JE, von Delft F, Ashworth A, Ahel I, Shoichet BK, Fraser JS

High-speed imaging reveals the bimodal nature of dense core vesicle exocytosis.

Proceedings of the National Academy of Sciences of the United States of America

Zhang P, Rumschitzki D, Edwards RH

Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition.

Proceedings of the National Academy of Sciences of the United States of America

Piacentino ML, Hutchins EJ, Andrews CJ, Bronner ME

Integrated gene analyses of de novo variants from 46,612 trios with autism and developmental disorders.

Proceedings of the National Academy of Sciences of the United States of America

Wang T, Kim CN, Bakken TE, Gillentine MA, Henning B, Mao Y, Gilissen C, SPARK Consortium, Nowakowski TJ, Eichler EE

Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.

Proceedings of the National Academy of Sciences of the United States of America

Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM

Aß and tau prions feature in the neuropathogenesis of Down syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB

Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.

Proceedings of the National Academy of Sciences of the United States of America

Frias ES, Hoseini MS, Krukowski K, Paladini MS, Grue K, Ureta G, Rienecker KDA, Walter P, Stryker MP, Rosi S

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