Proceedings of the National Academy of Sciences of the United States of America

Specific hypomethylation programs underpin B cell activation in early multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Ma Q, Caillier SJ, Muzic S, University of California San Francisco MS-EPIC Team, Wilson MR, Henry RG, Cree BAC, Hauser SL, Didonna A, Oksenberg JR

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C

Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child.

Proceedings of the National Academy of Sciences of the United States of America

Lévy R, Zhang P, Bastard P, Dorgham K, Melki I, Hadchouel A, Hartoularos GC, Neven B, Castelle M, Roy C, Toin T, Berteloot L, Bizien L, Abid H, Burgard M, Houhou-Fidouh N, Rozenberg F, Jouanguy E, Ye CJ, Gorochov G, Zhang Q, Casanova JL

Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway.

Proceedings of the National Academy of Sciences of the United States of America

Lu W, Skrzypczynska KM, Weiss A

RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.

Proceedings of the National Academy of Sciences of the United States of America

Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F

UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.

Proceedings of the National Academy of Sciences of the United States of America

Wolfe AL, Zhou Q, Toska E, Galeas J, Ku AA, Koche RP, Bandyopadhyay S, Scaltriti M, Lebrilla CB, McCormick F, Kim SE

A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America

Kang E, Kadoch C, Rubenstein JL, Lanier LL, Wells JA

Mechanotaxis directs Pseudomonas aeruginosa twitching motility.

Proceedings of the National Academy of Sciences of the United States of America

Kühn MJ, Talà L, Inclan YF, Patino R, Pierrat X, Vos I, Al-Mayyah Z, Macmillan H, Negrete J, Engel JN, Persat A

Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.

Proceedings of the National Academy of Sciences of the United States of America

Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S

Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.

Proceedings of the National Academy of Sciences of the United States of America

Wercberger R, Braz JM, Weinrich JA, Basbaum AI

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