Proceedings of the National Academy of Sciences of the United States of America

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

Proceedings of the National Academy of Sciences of the United States of America

Maciag AE, Yang Y, Sharma AK, Turner DM, DeHart CJ, Abdelkarim H, Fan L, Smith BP, Kumari V, Dyba M, Rigby M, Castillo Badillo JA, Adams L, Fornelli L, Fox S, Brafman A, Turbyville T, Gillette W, Messing S, Agamasu C, Wolfe AL, Gysin S, Chan AH, Simanshu DK, Esposito D, Chertov O, Stephen AG, Arkin M, Renslo A, Kelleher NL, Gaponenko V, Lightstone FC, Nissley DV, McCormick F

Population imaging of enterochromaffin cell activity reveals regulation by somatostatin.

Proceedings of the National Academy of Sciences of the United States of America

Rossen ND, Touhara KK, Castro J, Harrington AM, Caraballo SG, Deng F, Li Y, Brierley SM, Julius D

Mapping global brain reconfigurations following local targeted manipulations.

Proceedings of the National Academy of Sciences of the United States of America

Rabuffo G, Lokossou HA, Li Z, Ziaee-Mehr A, Hashemi M, Quilichini PP, Ghestem A, Arab O, Esclapez M, Verma P, Raj A, Gozzi A, Sorrentino P, Chuang KH, Perles-Barbacaru TA, Viola A, Jirsa VK, Bernard C

Intraflagellar transport trains can switch rails and move along multiple microtubules in intact primary cilia.

Proceedings of the National Academy of Sciences of the United States of America

Sun S, Liang B, Koplas A, Tikhonenko I, Nachury M, Khodjakov A, Sui H

Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes.

Proceedings of the National Academy of Sciences of the United States of America

Sierant MC, Jin SC, Bilguvar K, Morton SU, Dong W, Jiang W, Lu Z, Li B, López-Giráldez F, Tikhonova I, Zeng X, Lu Q, Choi J, Zhang J, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Sedore SC, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, King E, Wagner M, Srivastava D, Shen Y, Bernstein D, Porter GA, Newburger JW, Seidman JG, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Chung WK, Gelb BD, Seidman CE, Brueckner M, Lifton RP

Recessive genetic contribution to congenital heart disease in 5,424 probands.

Proceedings of the National Academy of Sciences of the United States of America

Dong W, Jin SC, Sierant MC, Lu Z, Li B, Lu Q, Morton SU, Zhang J, López-Giráldez F, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, Cnota JF, Wagner M, Srivastava D, Bernstein D, Porter GA, Newburger J, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Seidman J, Chung WK, Gelb BD, Seidman CE, Lifton RP, Brueckner M

Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.

Proceedings of the National Academy of Sciences of the United States of America

Asai R, Sinha S, Prakash VN, Mikawa T

Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.

Proceedings of the National Academy of Sciences of the United States of America

Jiang WI, Cao Y, Xue Y, Ji Y, Winer BY, Chandra R, Zhang XF, Zhang M, Singhal NS, Pierce JT, Chen S, Ma DK

Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America

Langley CA, Dietzen PA, Emerman M, Tenthorey JL, Malik HS

Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.

Proceedings of the National Academy of Sciences of the United States of America

Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R

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